Factors Contributing to Intra-Individual Variation of Serum Constituents: 2. Effects of Exercise and Diet on Variation of Serum Constituents in Healthy Subjects

Statland, Bernard E.; Winkel, Per; Bokelund, H.

doi:10.1093/clinchem/19.12.1380

Cited by 72 publications

(13 citation statements)

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“…Bilirubin, γGT and ALP were almost unaltered during the 7‐day measurement period. This finding was expected, as these enzymes are not present in muscle tissue, and is also in accordance with a previous study [18].…”

Section: Discussionsupporting

confidence: 94%

Muscular exercise can cause highly pathological liver function tests in healthy men

Pettersson

Hindorf

Persson

et al. 2007

Brit J Clinical Pharma

282

171

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What is already known about this subject • The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals. • Physical exercise can result in transient elevations of liver function tests. • There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent. What this study adds • Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting. • Liver function tests are significantly increased for at least 7 days after weightlifting. • It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies. Aim To investigate the effect of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting liver function in healthy men. Methods Fifteen healthy men, used to moderate physical activity not including weightlifting, performed an 1 h long weightlifting programme. Blood was sampled for clinical chemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma‐glutamyl transferase (γGT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK) and myoglobin] at repeated intervals during 7 days postexercise and at a follow‐up examination 10–12 days postexercise. Results Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P < 0.01) and remained increased for at least 7 days postexercise. Bilirubin, γGT and ALP remained within the normal range. Conclusion The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice.

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Section: Discussionsupporting

confidence: 94%

Muscular exercise can cause highly pathological liver function tests in healthy men

Pettersson

Hindorf

Persson

et al. 2007

Brit J Clinical Pharma

282

171

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“…The 96-hour fast incorporated into this study protocol achieved the desired outcome with loss of the 24-hour rhythm of serum phosphate from a group of normal adult male subjects. The rcsult, together with the accompanying reduction in the mean 24-hour serum adjusted calcium concentration, is consistent with the findings of other fasting studies (Statland et al, 1973;Elia et al, 1984). Of major significance, however, is that unlike the one previous study in which it was examined (Jubiz et al, 1972) we have demonstrated that our fasting protocol has led to attenuation of the normal circadian rhythm of PTH(1-84) as measured both by direct immunoreactivity and indirect bioactivity (NcAMP).…”

Section: Discussioncontrasting

confidence: 55%

Alteration of the circadian rhythm of intact parathyroid hormone following a 96‐hour fast

Logue

Christie

et al. 1994

Clinical Endocrinology

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“…We have tried to address this difficulty by using thresholds defined by percentiles of our data. Glucose levels are likely to fluctuate more in non-fasting samples than cholesterol levels, 53 and we therefore selected a relatively high cut-off for glucose in order to have reasonable specificity and sensitivity. Given that our estimated prevalence of MHO is within the range seen in previous studies, we feel that this is unlikely to have strongly biased our results, which remained similar if lower cut-points were used for cholesterol and glucose.…”

Section: Discussionmentioning

confidence: 99%

Do rapid BMI growth in childhood and early-onset obesity offer cardiometabolic protection to obese adults in mid-life? Analysis of a longitudinal cohort study of Danish men

et al. 2014

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ObjectiveSome obese individuals have no cardiometabolic abnormalities; they are ‘metabolically healthy, but obese’ (MHO). Similarly, some non-obese individuals have cardiometabolic abnormalities, that is, ‘metabolically at risk, normal weight’ (MANW). Previous studies have suggested that early-onset obesity may be associated with MHO. We aimed to assess whether body mass index (BMI) in childhood and early-onset obesity are associated with MHO.SettingGeneral population longitudinal cohort study, Denmark.ParticipantsFrom 362 200 young men (mean age 20) examined for Danish national service between 1943 and 1977, all obese men (BMI ≥31 kg/m2, N=1930) were identified along with a random 1% sample of the others (N=3601). Our analysis includes 2392 of these men attending a research clinic in mid-life (mean age 42). For 613 of these men, data on childhood BMI are available. We summarised childhood BMI growth (7–13 years) using a multilevel model. Early-onset obesity was defined as obesity at examination for national service.Outcome measurementWe defined metabolic health at the mid-life clinic as non-fasting serum cholesterol <6.6 mmol/L, non-fasting glucose <8.39 mmol/L and pulse pressure <48 mm Hg. Participants were categorised into four groups according to their obesity (BMI ≥30 kg/m2) and metabolic health in mid-life.Results297 of 1097 (27.1%) of obese men were metabolically healthy; 826 of 1295 (63.8%) non-obese men had at least one metabolic abnormality. There was no evidence that rapid BMI growth in childhood or early-onset obesity was associated with either MHO or the MANW phenotype, for example, among obese men in mid-life, the OR for MHO comparing early-onset obesity with non-early-onset obesity was 0.97 (95% CI 0.85 to 1.10).ConclusionsWe found no robust evidence that early-onset obesity or rapid BMI growth in childhood is protective for cardiometabolic health.

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Factors Contributing to Intra-Individual Variation of Serum Constituents: 2. Effects of Exercise and Diet on Variation of Serum Constituents in Healthy Subjects

Cited by 72 publications

References 0 publications

Muscular exercise can cause highly pathological liver function tests in healthy men

Muscular exercise can cause highly pathological liver function tests in healthy men

Alteration of the circadian rhythm of intact parathyroid hormone following a 96‐hour fast

Do rapid BMI growth in childhood and early-onset obesity offer cardiometabolic protection to obese adults in mid-life? Analysis of a longitudinal cohort study of Danish men

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