Factors Concerned with “Clinical Radiation Nausea”

Ss, Kurohara; Fw, George; Levitts, S; Rubin, Paul

doi:10.1148/86.2.262

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1968

2017

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Cited by 10 publications

(2 citation statements)

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“…Cancer victims unc~ergoing radiotnerapy involving the abdominal viscera must endure this side effect of treatment ( 16). The same type of response could poten tially inhibit the performance of individuals who are expected to carry ou t impor tan t tasks in the even t of nucl~a: catastrophes , e.g.…”

Section: Introductionmentioning

confidence: 99%

Drug Inhibition of First-Stage Radioemesis.

Gralla¹,

Krupp²,

Mattsson³

et al. 1977

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Section: Introductionmentioning

confidence: 99%

Drug Inhibition of First-Stage Radioemesis.

Gralla¹,

Krupp²,

Mattsson³

et al. 1977

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“…Metopimazine is a newly available phenothiazine which has been shown by experimental studies in dogs to be about 100 times as active orally as chlorpromazine in preventing apomorphine-induced emesis. 4 Preliminary uncontrolled clinical studies" suggested that nausea and vomiting of various etiologies were controlled in a high percentage of cases without producing undesirable side effects and that, in particular, only rarely was drowsiness observed after this medication.…”

mentioning

confidence: 99%

A controlled clinical study of metopimazine and perphenazine in treatment of radiation nausea and vomiting

Chu

Paulshock

Wallenstein

et al. 1969

Clin Pharma and Therapeutics

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The Department of Radiation Therapy, Memorial Hospital for Cancer and Allied Diseases, and the Division of Medical Research, Sloan-Kettering InstituteThe few controlled studies of the use of antiemetic drugs in the treatment or prevention of radiation nausea and vomiting reported in the literaturel-9 have pointed out some of the problems inherent in evaluating new drugs in this clinical setting. A large number of factors other than drugs can influence the results of treatment, and with modem methods of radiation therapy only 10 to 20 per cent of unselected patients will develop nausea or vomiting and require medication for radiation sickness1• 9 ; and, furthermore, as many as 50 to 70 per cent of these patients will be relieved by placebos. 1 • 4 • 6 • 9 The difficulties involved in discriminating between an active drug and a placebo under these circumstances are obvious and call for a wellcontrolled clinical assay designed in a way such that these factors might be taken into account.

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Acute Radiation Effects

Busby

1968

Space Clinical Medicine

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Factors Concerned with “Clinical Radiation Nausea”

Cited by 10 publications

References 3 publications

Drug Inhibition of First-Stage Radioemesis.

Drug Inhibition of First-Stage Radioemesis.

A controlled clinical study of metopimazine and perphenazine in treatment of radiation nausea and vomiting

Acute Radiation Effects

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