Factors Associated with Vitamin D Deficiency in European Adolescents: The HELENA Study

Valtueña, Jara; González‐Gross, Marcela; Huybrechts, Inge; Breidenassel, Christina; Ferrari, Marco; Mouratidou, Theodora; Gottrand, F.; Dallongeville, Jean; Azzini, Elena; Sioen, Isabelle; Gómez‐Martínez, Sonia; Cuenca-García, Magdalena; Kersting, Mathilde; Stehle, Peter; Kafatos, Anthony; Μanios, Yannis; Widhalm, Kurt; Moreno, Luis A.

doi:10.3177/jnsv.59.161

Cited by 63 publications

(31 citation statements)

References 39 publications

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“…Indeed, it has been shown previously that a consistent decline in physical activity is found over the school age years, with males decreasing about 2.7% per year and females decreasing about 7.4% per year [31]. Consistent with previous studies [5], [27], [28], [29], [30], [32], [33], [34], [35], gender and BMI each has an independent effect on serum vitamin D levels in the current study. It has been demonstrated that the prevalence of physical inactivity is higher in girls than boys and is higher in obese children than their normal-weight peers [31].…”

Section: Discussionsupporting

confidence: 92%

Suboptimal Vitamin D Status in a Population-Based Study of Asian Children: Prevalence and Relation to Allergic Diseases and Atopy

Yao

Chang

et al. 2014

PLoS ONE

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BackgroundNew evidence shows high prevalence of vitamin D deficiency in many countries and some studies suggest a possible link between vitamin D status and allergic diseases. The objectives of this study were to determine the prevalence of suboptimal vitamin D status in a population sample of Asian children and to investigate the relationship of vitamin D status with allergic diseases and atopy.MethodsChildren aged 5–18 years (N = 1315) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were evaluated using questionnaires, anthropometric measurements, and serum levels of 25-hydroxyvitamin D [25(OH)D] and total and specific immunoglobulin E (IgE).ResultsThe mean concentration of serum 25(OH)D was 20.4 ng/mL (SD: 7.1 ng/mL). Vitamin D deficiency (defined as serum 25(OH)D<20 ng/mL) was present in 670 subjects (51.0%), while vitamin D insufficiency (defined as serum 25(OH)D<30 ng/mL) was observed in 1187 subjects (90.3%). Older age (P<0.001), female gender (P<0.001), higher body mass index (P = 0.001), winter and spring seasons (compared to summer; P both<0.001), and passive smoking (P = 0.011) were independently associated with low serum 25(OH)D levels. After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05).ConclusionsLow serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern. Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.

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Section: Discussionsupporting

confidence: 92%

Suboptimal Vitamin D Status in a Population-Based Study of Asian Children: Prevalence and Relation to Allergic Diseases and Atopy

Yao

Chang

et al. 2014

PLoS ONE

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“…Our study revealed that the prevalence of vitamin D deficiency and insufficiency was highest in winter. Previous studies have also reported that the serum 25(OH)D concentration is lower in winter than in summer [29,30], which might because people are lack of enough sunlight expose and spent less time on outdoor exercise in a cold weather, and vitamin D supplementation is not available [31]. …”

Section: Discussionmentioning

confidence: 99%

Nutrient Status of Vitamin D among Chinese Children

et al. 2017

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Background: Vitamin D deficiency is considered to be a public health problem. However, the nutrient status of vitamin D in Chinese children is unclear. The aim of this study was to describe the vitamin D status among children aged under 18 years in southeast China. Methods: Children who visited the Huzhou Maternal and Child Care Hospital from January 2012 to August 2015 were included in this large cross-sectional study. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by electrochemiluminescence immunoassay. Vitamin D status was defined as deficiency (25(OH)D < 20 ng/mL), insufficiency (25(OH)D: 20–29 ng/mL) and sufficiency (25(OH)D ≥ 30 ng/mL). The association between relevant variables and vitamin D status was analyzed by a using generalized estimated equation model and a multivariate regression model. Results: 13,997 children aged under 18 years were included. Of these, 23.3% children suffered from low vitamin D status (deficiency and insufficiency), while 76.7% had a sufficient vitamin D status. The prevalence of low vitamin D status was 29.7% in winter and 23.4% in spring, which was higher than that in summer (21.4%) and autumn (19.9%). Clinical visiting children (32.1%) suffered more from low vitamin D than health examination children (17.6%). Additionally, age and season were independently and significantly associated with 25(OH)D concentrations, respectively. Conclusions: The deficiency and insufficiency status of vitamin D was very common among newborns and children aged one to 17 years. This indicates that more sunshine and vitamin D–fortified foods are necessary among Chinese children.

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“…One of the first studies showed a significant association between excessive daytime sleepiness and serum values of 25OHD <20 ng/mL only in black individuals (McCarty et al 2012). Valtueña et al (2013) found that lower levels of 25OHD concentrations were associated with shorter sleep duration (<8 h) in female teenagers. In this study, sleep duration was assessed by self-administered questionnaires, which only provide subjective information about the sleep pattern of subjects.…”

Section: Vitamin D and Sleepmentioning

confidence: 99%

The interfaces between vitamin D, sleep and pain

Oliveira

Hirotsu

Tufik

et al. 2017

Journal of Endocrinology

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The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin

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Factors Associated with Vitamin D Deficiency in European Adolescents: The HELENA Study

Abstract: Adolescence is a critical life-stage period characterised by rapid growth and development. Low circulating

Cited by 63 publications

References 39 publications

Suboptimal Vitamin D Status in a Population-Based Study of Asian Children: Prevalence and Relation to Allergic Diseases and Atopy

Suboptimal Vitamin D Status in a Population-Based Study of Asian Children: Prevalence and Relation to Allergic Diseases and Atopy

Nutrient Status of Vitamin D among Chinese Children

The interfaces between vitamin D, sleep and pain

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