Factors associated with uremic pruritus

Abstract

Background: The etiopathogenesis of uremic pruritus (UP) is multifactorial aspect, and it is thus necessary to elucidate its associated factors to develop efficient therapeutics approaches. This study aimed to verify the prevalence of UP and its associated factors. Methods and Findings:Prospective and cross-sectional study with patients undergoing hemodialysis at a university public hospital. The data were obtained between April 2014 and April 2015. The statistical analysis was carried out using multivariate regression models, and statistical significance was set at p<0.05. A total of 164 patients were included, and pruritus was reported in 64 (39%). In the multivariate analysis, a higher creatinine level was risk factor for pruritus (β=1.09, 95% CI 1.00-1.19; p=0.048), as was a lower level of hemoglobin (β=0.85, 95% CI 0.73-0.99; p=0.043). Dyslipidemia (β=1.52, 95% CI 0.12-2.91; p=0.03), obesity (β=2.40, 95% CI 1.03-3.78; p=0.001), higher levels of C-reactive protein (β=0.26, 95% CI 0.19-0.34; p<0.001) and black race (β=1.49, 95% CI -2.57 and 0.42; p<0.006) were associated with a greater intensity of pruritus. The use of a high-flux dialyzer was associated with a lower intensity of pruritus (β=-1.69, 95% CI -3.05-0.34; p=0.01). Conclusion:Uremic pruritus has a high prevalence in hemodialysis patients, and the data suggest that the higher the creatinine and the lower the hemoglobin levels are, the greater the risk of developing pruritus is. Dyslipidemia, obesity, and higher levels of C-reactive protein were associated with a greater intensity of pruritus, whereas the use of a high-flux dialyzer was associated with lower pruritus intensity.

Application of Acupressure in Reducing Pruritus Scale in Hemodialysis Patients

“…In a study by Ozen et al [6] regarding the factors that influence pruritus, it was found that patients with high levels of leukocytes and dry skin types experienced severe pruritus. Oliviera et al [7] found that pruritus has a high prevalence in high creatinine levels and low hemoglobin levels. Oliviera et al [7] also mention that high pruritus intensity can be affected by dyslipidemia, obesity, and high C-Reactive Protein (CRP) levels.…”

“…Oliviera et al [7] found that pruritus has a high prevalence in high creatinine levels and low hemoglobin levels. Oliviera et al [7] also mention that high pruritus intensity can be affected by dyslipidemia, obesity, and high C-Reactive Protein (CRP) levels. In contrast, the low intensity of pruritus is associated with the use of a high flow dialyzer.…”

The association between CKD-associated pruritus and quality of life in patients undergoing hemodialysis in Pakistan

“…Doing so can assist in the execution of strategies such as dialysis adequacy and metabolic stabilization, which can be adopted along with drug treatment. [10]…”

Is Acupressure Effective To Treat Pruritus In Hemodialysis Patients? A Literatur Review

“…Many factors are also believed to be the cause of pruritus. Research conducted by Gobo-Oliveira et al (4) showed a higher pruritus intensity occurred in patients with high creatinine, low hemoglobin, dyslipidemia, high CRP levels, and black race. In contrast, lower pruritus intensity was associated with high dialyzer use.…”