Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda

Lule, Swaib A.; Mawa, Patrice A.; Nkurunungi, Gyaviira; Nampijja, Margaret; Kizito, Dennison; Akello, Florence; Muhangi, Lawrence; Elliott, Alison M.; Webb, Emily L.

doi:10.1016/j.vaccine.2014.12.015

Cited by 28 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with studies that reported low production of IFN-γ, low response of T cells to some mitogens and increased T reg cells in cord blood of neonates born to women with placental malaria [43][44][45][46][47]. These alterations in the host immune response, associated with microscopic P. falciparum malaria, result in increased susceptibility to bacteraemia in children [48,49] and alteration of the vaccine response [7,9,50]. Therefore, it is essential in future to evaluate the effect of submicroscopic maternal infections in our setting on the immunity of neonates and children post-vaccination.…”

Section: Discussionsupporting

confidence: 90%

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Álvarez-Larrotta

Agudelo

Duque

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.

show abstract

Section: Discussionsupporting

confidence: 90%

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Álvarez-Larrotta

Agudelo

Duque

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…We also measured antibodies specific for infections that our participants may have had a high chance of encountering in childhood in this setting. These included respiratory syncytial virus (RSV) (14), adenovirus (15), Kaposi’s sarcoma herpes virus (KSHV) (16), cytomegalovirus (CMV) (17) and Epstein Barr virus (EBV) (18). M.tb purified protein derivative (PPD) was included as a positive control indicative of mycobacterial exposure.…”

Section: Resultsmentioning

confidence: 99%

“…The initial analyses were made using the Kruskal-Wallis test to compare antibody responses across the groups of uninfected controls, individuals with LTBI and active TB cases. Linear regression analysis with bootstrap confidence intervals was then be used to determine associations between M.tb infection status and antibody responses (12,17). Adjusting was done for the effects of potential confounders such as HIV infection, age, socioeconomic status (SES) and gender.…”

Section: Methodsmentioning

confidence: 99%

Mycobacterium tuberculosisinfection boosts B cell responses to unrelated pathogens

Kimuda

Andia-Biraro

Sebina

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Significance 42Mycobacterium tuberculosis (M.tb) has potent immunostimulatory properties and has been used in 43 adjuvant preparations to improve vaccine responses in animals. This study shows that natural M.tb 44 infection in humans is associated with increased antibody and B cell recall responses to heterologous 45 pathogens. This data suggests a potential role for M.tb antigens in immunotherapies designed to 46 maintain antibody immunity to diverse infections. 47

show abstract

“…Maternal infection with M. perstans during pregnancy is associated with higher infant IL-10 responses after BCG and tetanus vaccination, but there are no differences in gamma interferon (IFN-␥), IL-5, and IL-13 (319) production. Maternal infection with filariae (320), Trypanosoma cruzi (321), or S. mansoni (320) during pregnancy is associated with lower IFN-␥ production in children after BCG vaccination, while other helminth infections show no effect on infant responses to BCG vaccination (319,322,323). Empiric treatment of mothers with albendazole or praziquantel during pregnancy does not influence infant vaccine responses to BCG (324), diphtheria (314), HepB (314), Hib (314), measles (324), pertussis (314), or tetanus (324) vaccination ( Table 7).…”

Section: Gestational Age Birth Weight Feedingmentioning

confidence: 99%

“…Parasites. Infants who are symptomatically infected with malaria parasites have lower antibody responses to Hib (333), measles (318), MCV-C (345), Salmonella Typhi (intradermal), and tetanus (345-347) vaccination and lower cytokine responses (IFN-␥, IL-5, and IL-13) after vaccination with tetanus (319) and BCG (319,323) vaccines (Table 10). Children with asymptomatic malaria have lower GMTs after MCV-C (94, 348) and aP (349) vaccination but no difference in antibody responses to tetanus vaccination (350,351).…”

Section: Extrinsic Factorsmentioning

confidence: 99%

Factors That Influence the Immune Response to Vaccination

2019

View full text Add to dashboard Cite

SUMMARYThere is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight, feeding method, and maternal factors), and extrinsic factors (such as preexisting immunity, microbiota, infections, and antibiotics). Further, environmental factors (such as geographic location, season, family size, and toxins), behavioral factors (such as smoking, alcohol consumption, exercise, and sleep), and nutritional factors (such as body mass index, micronutrients, and enteropathy) also influence how individuals respond to vaccines. Moreover, vaccine factors (such as vaccine type, product, adjuvant, and dose) and administration factors (schedule, site, route, time of vaccination, and coadministered vaccines and other drugs) are also important. An understanding of all these factors and their impacts in the design of vaccine studies and decisions on vaccination schedules offers ways to improve vaccine immunogenicity and efficacy.

show abstract

Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda

Cited by 28 publications

References 38 publications

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Mycobacterium tuberculosisinfection boosts B cell responses to unrelated pathogens

Factors That Influence the Immune Response to Vaccination

Contact Info

Product

Resources

About