Factors Associated with Thyroid Dysfunction in Hypothyroidism-Endemic Region of Ravansar, 2017-2018: A Cross-Sectional Analysis

Abstract

10.30699/jambs.29.134.145 Background & Objective: Hypothyroidism is a prevalent condition in various regions all over the world, including Iran. This study aimed to identify the factors associated with thyroid dysfunctions in Ravansar area, Kermanshah province. Due to hypo and hyperthyroidism diversity and pathogeneses complexity, machine learning was also integrated; it is as an accurate and potent method for the dimensionality reduction to realize the study objective. Materials & Methods: In this study, 10069 individuals participated from Ravansar area. Data were taken from the Ravansar Non-Communicable Diseases (RaNCD) cohort study, which is a part of national PERSIAN cohort. Feature selection was done using random forests machine learning tool. The two thyroid diseases correlation was explored through conventional statistical procedures. Results: Female sex was the most significant risk factor for hypothyroidism (OR=6.24, CI: 4.13-9.63; P<0.001). Depression (OR=2.07, CI: 1.34-3.09; P<0.001), age group of 45-55 years (OR=1.56, CI: 1.18-2.07; P<0.01), daily salt consumption of >10 gr (OR=1.87, CI: 1.15-2.90; P<0.01), kidney stone (OR=1.35, CI: 1.02-1.78; P<0.05) and unsaturated fats intake (OR=1.01, CI: 1.00-1.02; P<0.05) were significantly associated with underactive thyroid condition. No significant associated factor was found for hyperthyroidism. Conclusion: Female sex is a global well-established hypothyroidism-associated factor. The results of the present study suggest taking some measures to reduce hypothyroidism, by addressing the intervening factors.

Thyroid Dysfunction and Risk Factors Among Adult People in Sulaimani Province/ Kurdistan-Iraq

“…Moreover, despite the differences found between healthy and unhealthy food people and between normal BMI and abnormal BMI people with abnormal thyroidal hormone concentration, statistically, there were no significant differences found in this study between them. In contrast with this finding, a study done in Iran found that abnormal BMI was significantly associated with underactive thyroid functions (Barzegari, et al 2021). Based on these results, people with no activity have a remarkable contribution to abnormal thyroid hormone concentrations, which is considered one of the most established risk factors.…”