Factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients: a retrospective cohort study

Abstract

ObjectiveThis study aimed to describe the epidemiological and clinical features and potential factors related to the time to return negative reverse transcriptase (RT)-PCR in discharged paediatric patients with COVID-19.DesignRetrospective cohort study.SettingUnscheduled admissions to 12 tertiary hospitals in China.ParticipantsTwo hundred and thirty-three clinical charts of paediatric patients with confirmed diagnosis of COVID-19 admitted from 1 January 2020 to 17 April 2020.Primary and secondary outcome measuresPrimary outcome measures: factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients. Secondary outcome measures: epidemiological and clinical features and laboratory results in paediatric patients.ResultsThe median age of patients in our cohort was 7.50 (IQR: 2.92–12.17) years, and 133 (57.1%) patients were male. 42 (18.0%) patients were evaluated as asymptomatic, while 162 (69.5%) and 25 (10.7%) patients were classified as mild or moderate, respectively. In Cox regression analysis, longer time to negative RT-PCR was associated with the presence of confirmed infection in family members (HR (95% CI): 0.56 (0.41 to 0.79)). Paediatric patients with emesis symptom had a longer time to return negative (HR (95% CI): 0.33 (0.14 to 0.78)). During hospitalisation, the use of traditional Chinese medicine (TCM) and antiviral drugs at the same time is less conducive to return negative than antiviral drugs alone (HR (95% CI): 0.85 (0.64 to 1.13)).ConclusionsThe mode of transmission might be a critical factor determining the disease severity of COVID-19. Patients with emesis symptom, complications or confirmed infection in family members may have longer healing time than others. However, there were no significant favourable effects from TCM when the patients have received antiviral treatment.

Association between time of onset and Omicron BA.2 RNA clearance time in children: a retrospective cohort study

“…In our study, viral clearance time may be prolonged with reduced lymphocyte counts. This may be related to the fact that neo-coronaviruses may directly infect lymphocytes, leading to lymphocyte depletion and reduced antiviral response ( 12 , 13 ). Regarding the age of children, the mean viral RNA clearance time was different between the under-5 and over-5 years old groups ( 12 ).…”

“…This may be related to the fact that neo-coronaviruses may directly infect lymphocytes, leading to lymphocyte depletion and reduced antiviral response ( 12 , 13 ). Regarding the age of children, the mean viral RNA clearance time was different between the under-5 and over-5 years old groups ( 12 ). In pediatric patients, the effect of age on the time to viral clearance still needs to be further explored.…”

Eficacia Y Seguridad De La Ivermectina en Pacientes Con Covid-19 Con Sintomas Leves: Revisión Sistemática Y Meta-Análisis

“…Esto podría deberse a la variabilidad en la población de estudio y sus características clínicas podría resultar en una diferencia en la cantidad de carga viral al inicio de la intervención y al tiempo de medición, de igual forma la diferencia entre el nivel de calidad de la evidencia siendo alta para el desenlace de promedio de días para ser negativa y baja para el porcentaje de pruebas negativas, por todo lo anterior podría existir una incertidumbre considerable en la coincidencia entre el efecto real y el estimado. (29,30) El análisis para la seguridad de la ivermectina evaluado mediante los efectos adversos arrojó que no existe una diferencia significativa entre el uso de ivermectina y el grupo control, por lo que se no se podría aseverar con certeza que los efectos adversos reportados en los estudios incluidos estén asociados a la ivermectina. En el trabajo realizado por Kow C, et al (23) reportaron que no hubo suficiente información de efectos adversos asociados a ivermectina en los estudios que incluyó.…”