Factors Associated with the Development of Severe Asthma Exacerbations in Children

Abstract

In this retrospective review, severe asthma exacerbations in children are associated with a more rapid onset of symptoms and are more likely to be associated with allergens or irritants, supporting the importance of atopy in this population.

Underuse of guideline-recommended long-term asthma management in children hospitalized to the intensive care unit: a multicenter observational study

“…30,31 Previous studies reported that children taking ICSs, a marker of chronic asthma severity, are at higher risk of ICU admission for asthma exacerbation. 11,32 In agreement with these studies, we identified an independent association of the current use of ICS with the risk of ICU admission. By contrast, the observed association of female sex with a higher risk of ICU admission is discordant with a previous study 33 ; the finding warrants further investigation.…”

Medical and Social Determinants of Health Associated with Intensive Care Admission for Asthma in Children

“…Therefore, race, SES, and hardship all contributed to risk for overall readmission for asthma, but they did not serve as predictors for initial severe asthma exacerbation. Other studies also have failed to find race as a risk factor for admission to the ICU (34)(35)(36)(37)(38).…”

“…Yet the comparability of the index acuity scores between enrollees (42,46,47). Although a variety of risk factors for severe asthma exacerbation previously have been reported, including secondhand tobacco smoke (SHS) exposure, adolescent age, overweight, family history, sensitization to fungal antigens, and respiratory infection, the most commonly reported association is between ICU admission and atopy (6,11,12,15,37,48,49). Allergically sensitized patients in our study, specifically those with sensitization to indoor allergens, were more likely to be admitted to the ICU.…”

Allergy in severe asthma

“…Emergency room visits and hospital admissions due to acute asthma attacks are increased in children who are sensitized and exposed to high levels of inhalant allergens in their homes, emphasizing the importance of 'allergy' in asthma exacerbations (7). The phenotypes of childhood onset allergic asthma and early sensitization are often associated with severe asthma in adulthood (8).…”