“…For most miners, the largest portion of their cumulative exposures was received prior to the start of follow-up because most of their work experience occurred before follow-up began and because the respirable coal mine dust concentrations were reduced after 1969, when the U.S. coal dust standard was enacted 230 USC 841-8451. Further, an important factor in disease development may be the residence time of dust in the lungs [Maclaren et al, 1989;Hurley et al, 19871, such that the earlier exposures might have a greater influence on disease development and progression. For these reasons, it is unlikely that miners' exposures were underestimated appreciably, particularly among the older miners, who were also those most likely to have developed disease.…”