Factors Associated with the Development of Thrombosis in Pediatric Behçet Disease

Abstract

ObjectiveThe present study aimed to compare the demographic, clinical, and laboratory characteristics of patients with pediatric Behçet disease (BD) with and without thrombosis to elucidate the factors that may contribute to the development of thrombosis.MethodsThis observational, descriptive, medical records review study included patients with BD (n = 85) who were diagnosed at age younger than 16 years at our clinic between 2010 and 2022. The demographic, clinical, and available laboratory data of patients with and without thrombosis were compared. The potential risk factors for the development of thrombosis were evaluated with multivariable logistic regression analysis.ResultsCentral venous sinus thrombosis was the most common type of thrombosis. Thrombosis was significantly more common in male patients (p = 0.002), and regression analysis revealed that being male was a risk factor for developing thrombosis. Genital ulcers were less common in patients with thromboses. Patients with thrombosis had higher erythrocyte sedimentation rates, C-reactive protein, leukocyte, and neutrophil counts, as well as antinuclear antibody positivity. In contrast, mean platelet volume and lymphocyte counts were significantly lower in patients with thrombosis. According to the logistic regression analysis, erythrocyte sedimentation rate value >17 mm/h was a risk factor for developing thrombosis (odds ratio, 1; confidence interval, 1.1–1.8; p = 0.012).ConclusionsMale sex has been associated with an increased risk of thrombosis in children with BD. Inflammatory parameters may serve as predictive factors for thrombosis in pediatric BD.

Behçet's yndrome: one year in review 2023

“…Vascular involvement in BS is more common among males, venous involvement is more frequent than arterial involvement, and superficial thrombophlebitis is strongly associated with vascular involvement (45)(46)(47). These were confirmed in retrospective chart surveys among both juvenile and adult cohort studies (48)(49)(50). Pulmonary artery involvement (PAI) can occur as aneurysms (PAA) with or without thrombosis or may present as isolated pulmonary artery thrombosis (PAT) (51).…”