Factors Associated With the Control of Severe Asthma

Hermosa, Juan Luis Rodríguez; Sánchez, Carlos Barcina; Rubio, Myriam Calle; Mínguez, Mercedes Muñoz; Walther, J.L. Álvarez-Sala

doi:10.3109/02770900903518835

Cited by 59 publications

(34 citation statements)

References 24 publications

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“…Male mice have a high IFN-γ/IL-5 ratio and low allergen-specific IgE level, but they develop asthma despite this and may require treatment to help overcome these conditions. Furthermore, male children have higher theophylline clearance53 and lower drug adherence during asthma exacerbation,54 but controlling their asthma is relatively easier 55…”

Section: Sex Differences In the Effectiveness Of And Adverse Reactionmentioning

confidence: 99%

Gender-Specific Asthma Treatment

Choi

2011

Allergy Asthma Immunol Res

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Because genetic characteristics vary among subjects, the therapeutic effects of a certain drug differ among patients with the same disease. For this reason, special interest has focused on tailored treatments. Although it is well known that sex is genetically determined, little attention has been paid to sex differences in the clinical features and treatment of asthma. Females are more likely to suffer allergic asthma, to have difficulty controlling asthma symptoms, and to show adverse effects to drugs. As asthma symptoms show cyclic changes depending on female hormone levels in many women of child-bearing age, the use of contraceptives may specifically help to treat female patients with asthma such as those with perimenstrual asthma and severe asthma. Generally, testosterone seems to suppress asthma, and dehydroepiandrosterone (DHEA), a less virilizing androgen, may be effective for treating asthma. Evidence exists for a therapeutic and steroid-sparing effect of DHEA. However, further studies on the optimal dose and route of DHEA for each sex are needed. Monitoring of the serum DHEA-S level is necessary for patients with asthma on inhaled steroid treatment, and at minimum, replacement therapy for patients with a low level of DHEA may be helpful for treating their asthma.

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Section: Sex Differences In the Effectiveness Of And Adverse Reactionmentioning

confidence: 99%

Gender-Specific Asthma Treatment

Choi

2011

Allergy Asthma Immunol Res

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“…The data extracted from each article included the elementary characteristics of the study (first author, year of publication, study population, sample size, follow-up duration, and follow-up loss), baseline characteristics of the participators (age at recruitment, gender, ethnicity, socioeconomic status, and smoking history), and clinical characteristics (diagnosis, duration, severity, lung function, asthma control status, asthma medications, adherence to treatment, and exacerbations during the previous year) (45,46). Study quality was assessed and scored independently by two reviewers (LZ and XZ) using the Newcastle-Ottawa Quality Assessment Scale (47).…”

Section: Details Of the Extracted Data And Quality Assessmentmentioning

confidence: 99%

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Zhang

Zheng³

et al. 2016

J. Thorac. Dis.

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Background:The longitudinal associations between psychological dysfunction (PD) and asthma exacerbations (AE) have not been adequately addressed. This study aimed to systematically assess the influence of PD on AE, and to determine whether different PD affects AE differentially. P<0.001], presenting as hospitalizations (RR adj =1.22, 95% CI: 1.12-1.34, P<0.001), unscheduled doctor visits (RR =4.26, 95% CI: 2.52-7.19), and emergency department (ED) visits (RR adj =1.06, 95% CI: 1.01-1.10, P=0.009) because of asthma. Depression significantly increased the risk of AE (RR adj =1.07, 95% CI: 1.04-1.11, P<0.001), presenting as hospitalizations (RR adj =1.26, 95% CI: 1.07-1.49, P=0.007) and ED visits (RR adj =1.06, 95% CI: 1.02-1.11, P=0.007) because of asthma. Anxiety was only associated with an increased risk of AE in pregnant women (RR =1.05, 95% CI: 1.01-1.08), possibly due to the small amount of data available on anxiety. The influence of PD on AE was only significant when the PD exposure time exceeded one year.Conclusions: Co-morbid PD adversely affects AE, and there are differential effects of depression and anxiety. Asthmatic subjects with PD may benefit from more attention when establishing a treatment regimen in clinical practice.

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“…Taken by itself, knowledge about asthma may not have a direct impact on the practical skills of disease management, but it contributes to patients' ability to adapt to the disease [1]. It has been shown that in patients with asthma, knowledge of the disease and adherence to treatment are associated with better control, better adherence and improved quality of life [2][3][4]. Thus, enhancing patients' asthma knowledge is an important preliminary step to achieving better outcomes in the longer term.…”

Section: Introductionmentioning

confidence: 99%

Asthma disease management—Australian pharmacists’ interventions improve patients’ asthma knowledge and this is sustained

Saini

LeMay

Emmerton

et al. 2011

Patient Education and Counseling

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Objectives: To assess any improvements in knowledge of asthma patients after a tailored education program delivered by pharmacists and measure the sustainability of any improvements. To ascertain patients' perceptions about any changes in their knowledge.Methods: 96 specially trained pharmacists recruited patients based on their risk of poor asthma control. A tailored intervention was delivered to patients based on individual needs and goals, and was conducted at three or four time points over six months. Asthma knowledge was assessed at the beginning and end of the service, and six and 12 months after it had ended. Patients' perceptions of the impact of the service on their knowledge were explored qualitatively in interviews.

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Factors Associated With the Control of Severe Asthma

Abstract: Many patients with severe asthma have poor control of their disease. The number of exacerbations is the variable with the greatest effect on control of asthma. Knowledge of the disease and adherence to treatment are associated with better control.

Cited by 59 publications

References 24 publications

Gender-Specific Asthma Treatment

Gender-Specific Asthma Treatment

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Asthma disease management—Australian pharmacists’ interventions improve patients’ asthma knowledge and this is sustained

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