Factors associated with temporal window failure in transcranial Doppler sonography

Lee, Chan-Hyuk; Jeon, Seol-Hee; Wang, Su-Jung; Shin, Byoung‐Soo; Kang, Hyun Goo

doi:10.1007/s10072-020-04459-6

Cited by 18 publications

(17 citation statements)

References 17 publications

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“…It is difficult to infer the success rate of t-ULM based on our present study compared to color Doppler imaging 33 , as we need a larger cohort. In Europe, so far, Sonovue® is routinely used in neurosonology in order to image difficult patients (absence of temporal bone window), with a good success rate, but it is difficult to foresee how the precision of t-ULM will be patient–dependent.…”

Section: Discussionmentioning

confidence: 85%

Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients

et al. 2021

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Changes in cerebral blood flow are associated with stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases and other pathologies. Brain angiograms, typically performed via computed tomography or magnetic resonance imaging, are limited to millimetre-scale resolution and are insensitive to blood-flow dynamics. Here, we show that ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculature in the adult human brain at microscopic resolution and the quantification of haemodynamic parameters. Adaptive speckle tracking to correct for micrometric brain-motion artefacts and for ultrasonic-wave aberrations induced during transcranial propagation allowed us to map the vascular network of tangled arteries, to functionally characterize blood-flow dynamics at a resolution of up to 25 μm, and to detect blood vortices in a small deep-seated aneurysm in a patient. Ultrafast ultrasound localization microscopy may facilitate the understanding of brain haemodynamics and of how vascular abnormalities in the brain are related to neurological pathologies.

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Section: Discussionmentioning

confidence: 85%

Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients

et al. 2021

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“…Moreover, the application of the TCD-based technique is limited due to temporal window failure in 8% to 20% of the subjects. 47 Meanwhile, the TOF technique used in this study can measure IBV fluctuation for all tested subjects. A study that tested this novel noninvasive TOF technique for patients with TBI showed a significant coincidence between noninvasive (VRx) CA and invasive (pressure reactivity index) CA, estimating the significant associations between VRx indexes and outcome of patients with TBI.…”

Section: Discussionmentioning

confidence: 99%

Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects

Hamarat

Deimantavičius

Dambrauskas

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time. Methods The CA status of 10 patients with NTG, 8 patients with HTG, and 10 healthy subjects was assessed, using an innovative noninvasive ultrasonic technique, based on intracranial blood volume slow-wave measurements. Identified in each participant were intraocular pressure, ocular perfusion pressure, and CA-related parameter volumetric reactivity index (VRx), as well as the duration and doses of the longest cerebral autoregulation impairment (LCAI). In addition, we calculated the associations of these parameters with patients’ diagnoses. Results The VRx value, the LCAI dose, and duration in healthy subjects were significantly lower than in patients with NTG ( P < 0.05). However, no significant differences were noted in these parameters between healthy subjects and HTG and between NTG and HTG groups. Conclusions NTG is associated with the disturbed cerebral blood flow and could be diagnosed by performing noninvasive CA assessments. Translational Relevance The VRx monitoring method can be applied to a wider range of patient groups, especially patients with normal-tension glaucoma.

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“…Acquisition of the TAW is affected by age, sex, race, thickness and texture of the temporal bone, 10,18) and soft tissue thickness of the temporal area. 19) The rate of success in recording blood flow signals decreases in Asian and African populations, women, and older adults. 10) The incidence of sufficient TAW presence was 77.1% in Japanese participants.…”

Section: Discussionmentioning

confidence: 99%

Reliability of cerebral vasoreactivity assessment from the submandibular window

et al. 2021

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Background and Purpose: Transcranial Doppler (TCD) is a noninvasive and effective technique for the measurement of cerebrovascular function. Measurement of breath holding index (BHI) in the middle cerebral artery is commonly performed to determine cerebrovascular reactivity. Nevertheless, a notable drawback of TCD is the absence of a transtemporal acoustic bone window. The submandibular window offers an alternative way to measure BHI. Here, we studied the diagnostic accuracy of cerebrovascular reactivity (CVR) in the internal carotid artery (ICA) as measured from the submandibular window. Methods: Twenty-five volunteers (13 male, 12 female) with sufficient temporal acoustic bone windows were assessed. BHI was measured by mean blood velocities before and after breath holding. The correlation of BHI measured in ICA (BHIi) and ipsilateral middle cerebral artery (BHIm) was assessed. Results:The mean age of the participants was 39.9 ± 13.7 years. The mean BHIm and BHIi values were 0.93 ± 0.29 and 0.92 ± 0.32, respectively. Spearman's correlation coefficient between BHIm and BHIi was 0.665 (p = 0.0003). The cutoff point of the BHIi value for CVR impairment determined by BHIm was 0.71 (sensitivity 80.0%, specificity 80.0%). Conclusion:Measuring BHI from the submandibular window may be a useful procedure in the case of temporal bone window insufficiency.

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Factors associated with temporal window failure in transcranial Doppler sonography

Cited by 18 publications

References 17 publications

Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients

Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients

Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects

Reliability of cerebral vasoreactivity assessment from the submandibular window

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