Factors Associated With Sustained Remission in Patients With Rheumatoid Arthritis

Martire, María Victoria; Claverie, Lucila Marino; Duarte, Vanesa; Secco, Anastasia; Mammani, Marta

doi:10.1016/j.reumae.2015.01.003

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…The erythrocyte sedimentation rate (ESR) and Creactive protein (CRP) are traditional inflammatory markers that have been used to help assess the activity of inflammation in various diseases, such as systemic lupus erythematosus [14][15][16][17], rheumatoid arthritis [18,19], and vasculitis [20]. However, there is still a lack of knowledge about the relevance of these systemic inflammatory parameters to renal inflammation.…”

Section: Introductionmentioning

confidence: 99%

Elevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis

Zheng

et al. 2020

BMC Nephrol

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Background A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindications, refusal of informed consent and limited technical support may stop the biopsy process. It is thus of great importance to explore approaches that could deduce probable pathologic changes. Methods A total of 81 biopsy-proven D-ATIN patients were enrolled from a prospective cohort of ATIN patients at Peking University First Hospital. The systemic inflammation score (SIS) was developed based on the CRP and ESR levels at biopsy, and patients were divided into high-SIS, median-SIS, and low-SIS groups. The demographic data, clinicopathologic features, and renal outcomes were compared. Results The SIS was positively correlated with inflammatory cell infiltration and was inversely correlated with interstitial fibrosis. The number of interstitial inflammatory cells increased significantly with increasing SISs. The proportions of neutrophils and plasma cells were the highest in the high-SIS group compared with the other two groups. Prednisone (30–40 mg/day) was prescribed in all patients. The high-SIS group tended to have more favorable renal restoration than the other two groups. By 12 months postbiopsy, a decreased eGFR (< 60 mL/min/1.73 m2) was observed in 66.7% of medium-SIS patients, 32.4% of high-SIS patients, and 30.4% of low-SIS patients. Conclusion The SIS was positively correlated with active tubulointerstitial inflammation and therefore could help to aid therapeutic decisions in D-ATIN.

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Section: Introductionmentioning

confidence: 99%

Elevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis

Zheng

et al. 2020

BMC Nephrol

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show abstract

“…The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are traditional in ammatory markers that have been used to help assess the activity of in ammation in various diseases, such as systemic lupus erythematosus [14][15][16][17] , rheumatoid arthritis 18,19 , and vasculitis 20 . However, there is still a lack of knowledge about the relevance of these systemic in ammatory parameters to renal in ammation.…”

Section: Introductionmentioning

confidence: 99%

Elevation of Erythrocyte Sedimentation Rate and C-reactive Protein Levels Reflects Renal Interstitial Inflammation in Drug-Induced Acute Tubulointerstitial Nephritis

Zheng

et al. 2020

Preprint

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Abstract Background: A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindications, refusal of informed consent and limited technical support may stop the biopsy process. It is thus of great importance to explore approaches that could deduce probable pathologic changes. Methods: A total of 81 biopsy-proven D-ATIN patients were enrolled from a prospective cohort of ATIN patients at Peking University First Hospital. The systemic inflammation score (SIS) was developed based on the CRP and ESR levels at biopsy, and patients were divided into high-SIS, median-SIS, and low-SIS groups. The demographic data, clinicopathologic features, and renal outcomes were compared. Results: The SIS was positively correlated with inflammatory cell infiltration and was inversely correlated with interstitial fibrosis. The number of interstitial inflammatory cells increased significantly with increasing SISs. The proportions of neutrophils and plasma cells were the highest in the high-SIS group compared with the other two groups.Prednisone (30–40 mg/day) was prescribed in all patients. The high-SIS group tended to have more favorable renal restoration than the other two groups. By 12 months postbiopsy, a decreased eGFR (<60 mL/min/1.73 m 2 ) was observed in 66.7% of medium-SIS patients, 32.4% of high-SIS patients, and 30.4% of low-SIS patients. Conclusion: The SIS was positively correlated with active tubulointerstitial inflammation and therefore could help to aid therapeutic decisions in D-ATIN. Keywords: C reactive protein, erythrocyte sedimentation rate, interstitial inflammation, drug-induced acute tubulointerstitial nephritis.

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Predictors and the optimal duration of sustained remission in rheumatoid arthritis

et al. 2019

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Factors Associated With Sustained Remission in Patients With Rheumatoid Arthritis

Cited by 5 publications

References 24 publications

Elevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis

Elevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis

Elevation of Erythrocyte Sedimentation Rate and C-reactive Protein Levels Reflects Renal Interstitial Inflammation in Drug-Induced Acute Tubulointerstitial Nephritis

Predictors and the optimal duration of sustained remission in rheumatoid arthritis

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