Factors Associated with Suboptimal Antiretroviral Therapy Adherence to Dose, Schedule, and Dietary Instructions

Schönnesson, Lena Nilsson; Williams, Mark L.; Ross, Michael W.; Bratt, Göran; Keel, Blair

doi:10.1007/s10461-006-9160-0

Cited by 51 publications

(31 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although causal inferences cannot be made, our results suggest that an effective clinical management of psychological symptoms, particularly of depression and anxiety, may improve the functioning and well-being of both co-infected and mono-infected patients. The recognition and effective management of these symptoms are relevant concerns largely because of the negative effects of such symptoms on cART adherence and persistence (Gonzalez et al, 2011;Schönnesson et al, 2007;Springer et al, 2012) and the possible worsening of disease progression (Nanni et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

View full text Add to dashboard Cite

This study compared the quality of life (QoL) of HIV-infected patients with and without hepatitis C and examined the sociodemographic, HIV-related and psychological symptoms associated with the QoL domains in patients with HIV/HCV co-infection. The sample consisted of 248 HIV/HCV coinfected patients (18-74 years, 81.5% male) and 482 patients only with HIV (24-78 years, 62.7% male). Participants completed the WHOQOL-HIV-Bref questionnaire and the Brief Symptom Inventory (BSI). The HIV/HCV co-infected patients reported significantly lower QoL in all domains, as well as significantly lower scores in 10 of the 17 specific facets. Overall, among the co-infected patients, male gender, employment, combination antiretroviral therapy use and fewer depressive and anxiety symptoms were significantly associated with higher QoL. Symptoms of psychological distress accounted for significant variability in the QoL scores of co-infected patients. These data reinforce the need for tailored interventions to improve the overall well-being of HIV/HCV co-infected patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

View full text Add to dashboard Cite

show abstract

“…In spite of its importance, studies indicate that high adherence is a significant problem among HIV+ individuals (9–11). Research indicates that many factors are related to adherence including covariates of race, such as discrimination (12, 13), psychiatric diagnoses (14,15) such as depression, alcohol or other drug use (16–18), stress (18,19), social support (20) and coping styles (21). However, there is emerging literature suggesting that tobacco smoking, which is highly prevalent among HIV+ individuals, may also be associated with poor ART adherence (22–26).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between ART Adherence and Smoking Status Among HIV+ Individuals

et al. 2015

View full text Add to dashboard Cite

Smoking is highly prevalent among HIV+ individuals and studies indicate that it may be associated with poor ART adherence, though the relationship is poorly understood. In addition little is known about interest in quitting among HIV+ smokers who are having adherence difficulties. We examined smoking and ART adherence among 203 HIV+ individuals enrolled in a randomized trial of interventions to increase ART adherence. Prior analyses indicated there were no overall treatment group effects. Smoking status and motivation to quit was assessed at baseline and ART adherence was assessed at week 12, 24, 36, and 48. Longitudinal generalized estimating equation analysis that controlled for treatment group revealed that smoking status was not significantly related to adherence over time. Motivation to quit was high with 58% intending to quit in the next 6 months and 25% intending to quit in the next 30 days. Findings suggest that smoking is not associated with adherence among those with adherence difficulties. However it does not diminish importance of addressing both behaviors especially given HIV+ smokers substantial interest in changing smoking behavior.

show abstract

“…(3, 4) Behavioral research on HIV treatment adherence has identified several factors that reliably predict sub-optimal treatment outcomes from ART, including mood disturbances, poor social support, and impoverished living conditions. (5–8) Another common and robust impediment to medication adherence is alcohol use. (9)…”

Section: Introductionmentioning

confidence: 99%

Viral Suppression and Antiretroviral Medication Adherence Among Alcohol Using HIV-Positive Adults

et al. 2013

View full text Add to dashboard Cite

Background Substance use is a known predictor of poor adherence to antiretroviral therapies (ART) in people living with HIV/AIDS. Less studied is the association between substance use and treatment outcomes, namely suppression of HIV replication. Methods Adults living with HIV (N=183) who reported alcohol use in the previous week and receiving ART were observed over a 12-month period. Participants completed computer interviews, monthly-unannounced pill counts to monitor ART adherence, and daily cell-phone delivered interactive-text assessments for alcohol use. HIV viral load was collected at baseline and 12-month follow-up from medical records. Analyses compared participants who had undetectable HIV viral loads at baseline and follow-up (sustained viral suppression) to those with unsustained viral suppression. Analyses also compared participants who were adherent to their medications (> 85% pills taken) over the year of observation to those who were non-adherent. Results Fifty- two percent of participants had unsustained viral suppression; 47% were ART non-adherent. Overall results failed to demonstrate alcohol use as a correlate of sustained viral suppression or treatment adherence. However, alcohol use was associated with non-adherence among participants who did not have sustained viral suppression; non-adherence in unsustained viral suppression patients was related to drinking on fewer days of assessment, missing medications when drinking, and drinking socially. Conclusions Poor HIV treatment outcomes and non-adherence were prevalent among adults treated for HIV infection who drink alcohol. Drinking in relation to missed medications and drinking in social settings are targets for interventions among alcohol drinkers at greatest risk for poor treatment outcomes.

show abstract

Factors Associated with Suboptimal Antiretroviral Therapy Adherence to Dose, Schedule, and Dietary Instructions

Cited by 51 publications

References 39 publications

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

The Relationship Between ART Adherence and Smoking Status Among HIV+ Individuals

Viral Suppression and Antiretroviral Medication Adherence Among Alcohol Using HIV-Positive Adults

Contact Info

Product

Resources

About