Factors associated with sputum culture conversion in patients with pulmonary tuberculosis

Musteikienė, Greta; Miliauskas, Skaidrius; Žemaitis, Marius; Sakalauskas, Raimundas

doi:10.1183/1393003.congress-2017.pa2720

Cited by 6 publications

(7 citation statements)

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“…In a clinical trial conducted in Ethiopia, daily supplementation with vitamin D could ameliorate TB symptoms but it played no role in sputum smear conversion . A recent study in Lithuania also concluded that the sputum culture conversion rate in TB patients was not associated with serum vitamin D levels at baseline .…”

Section: Discussionmentioning

confidence: 97%

Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China

Lin

Bai

Zhang

et al. 2020

Tropical Med Int Health

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Objective Tuberculosis (TB) treatment success rates are high in China, but there are still a considerable number of cases who have unfavourable treatment outcomes (UTO). We aimed to determine the proportion of TB patients with UTO and to assess whether baseline characteristics that included glycaemic status [normal fasting blood glucose (FBG), transient hyperglycaemia and diabetes mellitus (DM)] and vitamin D status were associated with UTO. Method Prospective cohort study conducted between November 2015 and July 2016 at six clinics within routine TB services in Jilin province, where persons with TB were consecutively recruited. Data analysis was performed using the chi‐squared test and multivariate logistic regression. Results Of the 306 recruited TB patients, 96 (31.4%) had smear‐positive pulmonary TB, 187 (61.1%) had smear‐negative pulmonary TB and 23 (7.5%) had extrapulmonary TB (EPTB). Of these, 95 (31.1%) had normal blood glucose, 83 (27.1%) had transient hyperglycaemia and 128 (41.8%) had DM. 227 (74.2%) patients had vitamin D deficiency/severe deficiency. There were 125 (40.8%) patients with UTO of whom the majority were lost to follow‐up (57.6%) or not evaluated (28.8%). UTO was significantly associated with smear‐negative pulmonary TB (P = 0.009), EPTB (P < 0.001) and DM (P = 0.007). Conclusion The proportion of TB patients with UTO increased with smear‐negative pulmonary TB, EPTB and DM. TB programmes need to pay more attention to these issues and ensure intensive patient support to those at risk and early detection of DM.

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Section: Discussionmentioning

confidence: 97%

Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China

Lin

Bai

Zhang

et al. 2020

Tropical Med Int Health

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“…However, other studies in Northwest Ethiopia have reported relatively higher culture conversion by the third (61.7%) and sixth (88.6%) months with median time of 72 days (85.5%) and (14.5%) did not have culture conversion 6 . Patient with High smear grade is unlikely to convert after the first month of treatment and because of this unlikely event of sputum culture conversion, there is no need to repeat bacteriological testing after the first month of therapy 13 . This study also shown in our research, the majority of patient with sputum smear 2+ and 3+ experiencing culture conversion at their second month of treatment.…”

Section: Discussionmentioning

confidence: 99%

Drug-Resistant Tuberculosis: Correlation between Positivity of Acid-Fast Bacilli Sputum and Time to Conversion on Patients with Short-Term Treatment Regimen

Kusmiati¹,

Charisma²,

Nugroho³

et al. 2020

J Pure Appl Microbiol

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Drug-resistant tuberculosis (DR-TB) is a worldwide global burden and related to poor treatment outcomes. Monitoring the progress of DR-TB treatment can be carried out microscopic with Acid-Fast Bacilli (AFB) sputum smear and assessed from the beginning or the first time the patient is diagnosed and monthly to determine the sequential conversion of AFB baseline to the next month twice until it becomes negative. The prolonged conversion has been associated with infectiousness and treatment outcomes. This study was aimed to determine the correlation between positivity of AFB sputum and time to conversion in DR-TB patients with short-term treatment (STR) regimen. An analytic retrospective at hospital collected from medical records of DR-TB patients, from September 2017 to July 2018. Spearman technique was used to analyze the data with p < 0.05. From the total of 151 DR-TB patients on STR regimen, 51 patients were enrolled consisting of 30 (58.8%) males and 21 (41.2%) females with ages average were 51 ± 12.9 years old. Overall, 39 (76.5%) patients had time of AFB conversion in the first month, 9 (17.6%) patients in the second months, 2 (3.9%) patients in the third months, and 1 (2%) patient in the fourth months. Among those patients, 26 (51%) patients had completed the treatment outcomes, 22 (43.1%) were loss to follow-up, 1 (2%) patient had the treatment failure, and 2 (3.9%) were died. There was no significant correlation between AFB sputum baseline (Scanty, 1+, 2+, 3+) with the time to sputum conversion (p > 0.05). AFB sputum have significant correlation with time of culture conversion (p < 0.05), and treatment compliance was not associated with time of AFB sputum conversion (p > 0.05). There was no significant relation between positivity of AFB baseline and time to sputum conversion in DR-TB patients on short-term treatment (STR) regimen. AFB sputum have significant correlation with time of culture conversion in DR-TB patients on short-term treatment (STR) regimen.

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“…According to specialist consultation in evaluating patients' responses to anti-TB treatment and verifying the sterilizing efficacy of the medications, the development of tuberculosis (TB) biomarkers may have an impact on standard clinical practice and possibly help to identify novel clinical endpoints [19,20,21]. If new biomarkers are discovered, they may aid in TB treatment prognosis and therapy modification decisions [22], [23]. Recent research has found that a number of chemokines have a role in luring different immune cells to the lung through tuberculosis infection [24].…”

Section: A the Importance Of Estimating The Level Of Inflammatory Mar...mentioning

confidence: 99%

Potential Immunological Biomarker for Diagnosis and Prognosis of Tuberculosis

Hussain

Mohammed²,

Ali³

2023

EJBIOMED

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Tuberculosis (TB) is one of the most common infectious diseases in the world, which has led to numerous deaths. Hence, developing an efficient diagnostic method is essential to monitor and control such deadly infectious diseases. In the current study, the serum levels of four inflammatory markers (CXCL10, CXCL9, suPAR, and MMP9) and the expression NF-κB gene were evaluated as potential immunological markers for diagnosis and prognosis of tuberculosis, using ELISA and qPCR technique respectively. Thirty new TB patients and equal numbers of under treatment TB patients and control (healthy people) were conscripted in this study. The results showed significant differences in the serum level of CXCL10 among the three groups (p value 0.003) and between new and under treatment patients (P value 0.004). A significant difference in the CXCL9 level in the serum was observed between the new TB patients and the healthy group with p value 0.028 but didn’t reach the significant level between the new and under treatment patients. The serum level of suPAR was higher in new patients (106.59pg/ml) followed by treated patients (89.66pg/ml) and lowest in healthy group (80.71pg/ml) but didn’t reach the significant level. Also, the serum level of MMP-9 did not show a significant difference between the tested groups, but it was slightly higher in new patients (21.45ng/ml) compared to the healthy group (20.70ng/ml). The amount of NF-κB gene expression was significantly higher in new patients (8.21-fold change) than in under treatment patients (2.95-fold change) in comparing with healthy people.

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Factors associated with sputum culture conversion in patients with pulmonary tuberculosis

Cited by 6 publications

References 0 publications

Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China

Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China

Drug-Resistant Tuberculosis: Correlation between Positivity of Acid-Fast Bacilli Sputum and Time to Conversion on Patients with Short-Term Treatment Regimen

Potential Immunological Biomarker for Diagnosis and Prognosis of Tuberculosis

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