Factors Associated with Splenomegaly amongst Patients with Sickle Cell Disease in Cameroon

Prevalence of splenomegaly and factors contributing to splenomegaly among pancytopenia patients: a facility-based cross-sectional study

“…10 The findings which were found lower than our study findings were from Cameroon, where the analytical cross sectional study done among children has shown that out of 403 children with sickle cell anemia assessed for splenomegaly has reported prevalence of 35%. 11 The risk factors associated with splenomegaly has been reported as acute or chronic leukemia, infections like tuberculosis, malaria and endocarditis, hepatic and heart related diseases were found to be significantly associated with splenomegaly in California's retrospective study findings. 10 The study done in Australia among HIV patients has shown that existing liver disease is associated with splenomegaly.…”

“…Further studies with more rigorous methods, longer follow-up, outcome determination, and a bigger sample size are required in order to successfully prevent and manage pancytopenia disease in patients with splenomegaly. 11 One of the limitations of this study is the small sample size. Another limitation was the design of the study.…”

“…9 The same study found no association with age and CD4 count with splenomegaly status of the patients. 9 The risk factors found associated with splenomegaly found in patients with sickle cell anemia are malaria, hepatomegaly, platelet count, intake of nonsteroidal anti-inflammatory drugs, fraction of hemoglobin F and S. 11 The study population only included the admitted patients of pancytopenia and was able to enroll only less number of pancytopenia patients. These are the limitation of our study.…”