Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults

Gonçalves, Lúcio Souza; Silva, Arley; Ferreira, Sônia Maria Soares; Sousa, Celso Oliveira de; Fontes, Tatiana Vasconcellos; Vettore, Mário Vianna; Torres, Sandra Regina

doi:10.1016/j.archoralbio.2012.10.007

Cited by 13 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a glucose concentration of 18 g/dL, which can be easily obtained from alcohol, promotes the occurrence of oral candidiasis by increasing biofilm formation and C. albicans adhesion [20]. In this study, 8.9% of those who did smoke and drink alcohol were lower, but in Gonçalves et al [21] and Epstein et al [22]'s studies, an important association was observed between oral candidiasis and smoking or alcohol consumption.…”

Section: Discussionmentioning

confidence: 48%

Clinical Characteristics of Patients with Oral Candidiasis

Kim

2021

J Oral Med Pain

View full text Add to dashboard Cite

Oral candidiasis is the most common fungal infection in the oral cavity which is usually diagnosed from clinical findings. A retrospective study was conducted to identify risk factors for oral candidiasis and to characterize the demographic and clinical features of affected patients.Methods: Methods: From January 1, 2019 to December 31, 2019, it consisted of 90 oral candidiasis patients diagnosed based on clinical finding and treated with antifungal drugs. As a retrospective study of those people, surveys were conducted on sex, age, systemic disease, a use of dentures, complaints of dry mouth, smoking and alcohol consumption, culture on potato dextrose agar (PDA) medium, culture on chromogenic agar (CA) medium and a duration of antifungal treatment.Results: Results: Among 90 selected patients, the male and female ratio was 41:49. Overall, female had a higher infection rate than male in all age groups. In this study, oral candidiasis was not clearly susceptible to dry mouth, smoking or drinking, wearing dentures and association with systemic disease. Among 90 patients with oral candidiasis, 83 had colonies formed on PDA medium and 53 had colonies formed on CA medium. The duration of antifungal treatment was highest between 5 and 8 weeks. In addition, there was statistical significance between the culture results in CA medium and the duration of antifungal treatment.Conclusions: Conclusions: Generally, old age or infants, dry mouth, smoking, a use of dentures and endocrine abnormalities are risk factors to increase oral candidiasis; however, in this study, it was mainly found in the elderly aged 60 or older regardless of sex and the incidence of oral candidiasis was not obviously related with patients with dry mouth, smoking or drinking, denture wearers and endocrine abnormalities. Interestingly, when the fungi were cultured in CA medium, the duration of antifungal treatment was increased.

show abstract

Section: Discussionmentioning

confidence: 48%

Clinical Characteristics of Patients with Oral Candidiasis

Kim

2021

J Oral Med Pain

View full text Add to dashboard Cite

show abstract

“…Viral invasion of these cells, subsequently leads to the uncontrolled replication of the virus which exhausts and cripples the immune system while simultaneously leaving the infected vulnerable to opportunistic diseases such as those caused by Mycobacterium spp. ; this infection then later progresses to Acquired Immunodeficiency Syndrome (AIDS) [96]. However, early diagnosis is important even in asymptomatic individuals because it will bring about early drug administration which will impair the multiplication and assembly mechanisms of the virus, thus preventing the spread of the virus and delay its effects and allowing infected individuals to live an adequate standard of life, but also provide them a better chance at survival [97].…”

Section: Aptamer Application In the Diagnosis Of Infectious Diseasesmentioning

confidence: 99%

Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases

et al. 2018

View full text Add to dashboard Cite

Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases have been blamed on drug resistance and the inefficacy of available diagnostic tools, particularly those which are immunologically-based. Antibody-based tools rely solely on antibody production for diagnosis and for this reason they are the major cause of diagnostic delays. Unfortunately, the control of these diseases depends on early detection and administration of effective treatment therefore any diagnostic delay is a huge challenge to curbing these diseases. Hence, there is a need for alternative diagnostic tools, discovery and development of novel therapeutic agents. Studies have demonstrated that aptamers could potentially offer one of the best solutions to these problems. Aptamers are short sequences of either DNA or RNA molecules, which are identified in vitro through a SELEX process. They are sensitive and bind specifically to target molecules. Their promising features suggest they may serve as better diagnostic agents and can be used as drug carriers for therapeutic purposes. In this article, we review the applications of aptamers in the theranostics of cancer and some infectious diseases.

show abstract

“…Oral candidiasis is a common chronic condition that affects a large proportion of the population, especially denture wearers. Chronic atrophic candidiasis (CAC), also known as denture stomatitis, is the most common manifestation of Candida infection and affects more than 65% of individuals wearing maxillary partial dentures (Gonçalves et al, 2013;Chambo-Filho et al, 2014;Santos et al, 2016;Punnia-Moorthy, 2019). CAC is usually detected during intraoral examination and characterized as inflammation and erythema of the oral mucosal surfaces covered by the dental prosthesis (Armstrong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)

et al. 2020

View full text Add to dashboard Cite

Abstract The treatment of choice for chronic atrophic candidiasis (CAC), also known as denture stomatitis, is topical antifungal therapy. This study aimed to isolate, identify, and assess the antifungal susceptibility of Candida species from mucosal sites in denture wearers with a diagnosis of CAC and determine the prevalence of associated variables. The sample consisted of 44 patients wearing complete or partial dentures who had a clinical diagnosis of CAC. Using sterile cotton swabs, specimens were collected from the oral mucosa of all patients and grown at 30ºC for 48 h in CHROMagar Candida, as a means of isolating and screening the species. The complementary identification of the species was performed using the VITEK 2 automated system (BioMérieux), as well as the determination of their susceptibility to antifungal agents. Data were analyzed using the chi-square test. STATA 13.1 was used for statistical analysis (α = 5%). Of 44 patients with CAC, 33 (75%) had lesions classified as Newton type II. Yeasts were isolated in 38 cases. The most prevalent species was Candida albicans. None of the isolates were resistant to the antifungals tested. Our findings suggest that current indications for antifungal agents are appropriate. Also, antifungal susceptibility testing and proper fungal identification can help dentists to determine the optimal course of treatment for CAC.

show abstract

Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults

Cited by 13 publications

References 21 publications

Clinical Characteristics of Patients with Oral Candidiasis

Clinical Characteristics of Patients with Oral Candidiasis

Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases

Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)

Contact Info

Product

Resources

About