Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome

Mikolašević, Ivana; Milić, Sandra; Orlić, Lidija; Stimac, Davor; Franjić, Neven; Targher, Giovanni

doi:10.1016/j.jdiacomp.2016.05.014

Cited by 39 publications

(66 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous few studies have also documented the strong association of risk factors like obesity and insulin resistance with NAFLD . A recent study has shown that one or more components of metabolic syndrome among NAFLD patients can be associated with significant steatosis and fibrosis as assessed by transient elastography . There is also data showing that diabetes is an independent predictor for cirrhosis and progression to decompensation in chronic hepatitis C patients .…”

Section: Discussionmentioning

confidence: 99%

Impact of family history of metabolic traits on severity of non‐alcoholic steatohepatitis related cirrhosis: A cross‐sectional study

Bhadoria

Kedarisetty

Bihari

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of family history of metabolic traits on severity of non‐alcoholic steatohepatitis related cirrhosis: A cross‐sectional study

Bhadoria

Kedarisetty

Bihari

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

“…For example, it has been recently demonstrated that higher CAP categories (i.e., more steatotic liver, CAP>300 dB/m) influence the results of liver stiffness measurement (LSM) leading to overestimation of fibrosis especially in the lower range of the fibrosis spectrum [35]. This might have been the reason why significant fibrosis (defined as LSM≥7 kPa) and even cirrhosis (LSM≥10.3 kPa) were observed with a prevalence of 16.7-18.8% and 13.8%, respectively, as reported by the authors who used transient elastography and CAP to assess liver steatosis and fibrosis [36, 37]. It should be also noticed that LSM cut-off values for significant fibrosis and cirrhosis as measured by TE are not the same for different etiologies of liver diseases [38].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Grade of Liver Steatosis Is Independently Associated with the Risk of Metabolic Syndrome

Mustapić

Ziga

Matić

et al. 2018

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

The aim of the study was to explore (a) prevalence and grade of nonalcoholic fatty liver (NAFL) among outpatients referred for abdominal ultrasound (US) examination and (b) relationship between the presence and severity of liver steatosis and metabolic syndrome (MS). This was a retrospective analysis of patients without history of liver disease examined by abdominal US in the University hospital setting. US was used to detect and semiquantitatively grade (0-3) liver steatosis. Data on patients' age, gender, body mass index (BMI), impaired glucose metabolism (IGM), atherogenic dyslipidaemia (AD), raised blood pressure (RBP), transaminases, and platelet counts were obtained from medical records. MS was defined as having at least 3 of the following components: obesity, IGM, AD, and RBP. Of the 631 patients (median age 60 years, median BMI 27.4 kg/m2, and 57.4% females) 71.5% were overweight and 48.5% had NAFL. In the subgroup of 159 patients with available data on the components of MS, patients with higher US grade of steatosis had significantly higher BMI and increased prevalence of obesity, IGM, AD, RBP, and accordingly more frequently had MS, whereas they did not differ in terms of age and gender. NAFL was independently associated with the risk of having MS in a multivariate model adjusted for age, gender, BMI, and IGM. The grade of liver steatosis did not correlate with the presence of liver fibrosis. We demonstrated worrisome prevalence of obesity and NAFL in the outpatient population from our geographic region. NAFL is independently associated with the risk of having MS implying worse prognosis.

show abstract

“…Thus, in Western countries, the most common cause of chronic liver disease is NAFLD. It is also assumed that by 2030, NAFLD will become the most recurrent indication for liver transplantation 11 12. NAFLD is closely related to MetS and its individual components.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…The main pathogenic factor in NAFLD development and progression is IR. IR is associated with hepatic steatosis and NASH 11 13 15 16. Currently, there are two main hypotheses regarding how the ‘parts’ should be positioned: the ‘two-hit’ and the ‘multi-hit’ theory 17…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-alcoholic fatty liver disease and colorectal cancer

Mikolašević

Orlić

Štimac

et al. 2016

Postgraduate Medical Journal

View full text Add to dashboard Cite

As a significant cause of cancer death worldwide, colorectal cancer (CRC) is still one of the most common cancers in the world. The most efficient strategies to reduce CRC incidence include identifying risk factors for CRC and performing a preventive colonoscopy in high-risk populations. Some well-established risk factors for CRC development include hereditary syndromes and inflammatory bowel disease. Of note, in recent years, attention has been given to new evidence indicating that more than 75%-95% of CRC occurs in individuals with little or no genetic risk. For these individuals, the risk for CRC is associated with their lifestyle and dietary factors, including central obesity, overweight and physical inactivity. Recently, evidence demonstrated a connection between non-alcoholic fatty liver disease (NAFLD) and CRC. Insulin resistance and metabolic syndrome (MetS) are common risks that NAFLD and colorectal neoplasms share. The incidence of NAFLD is increasing in parallel with an increasing prevalence of MetS and obesity. Consequently, the question arises: will the incidence of CRC increase together with this dramatic increase in obesity, MetS and ultimately NAFLD prevalence? Recent studies of adenomatous polyps, CRC and NAFLD are discussed in this manuscript.

show abstract

Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome

Cited by 39 publications

References 28 publications

Impact of family history of metabolic traits on severity of non‐alcoholic steatohepatitis related cirrhosis: A cross‐sectional study

Impact of family history of metabolic traits on severity of non‐alcoholic steatohepatitis related cirrhosis: A cross‐sectional study

Ultrasound Grade of Liver Steatosis Is Independently Associated with the Risk of Metabolic Syndrome

Non-alcoholic fatty liver disease and colorectal cancer

Contact Info

Product

Resources

About