Study Objectives: Parents of children with chronic illnesses have poorer health related quality of life (HRQoL), shorter sleep duration, and poorer sleep quality than parents of healthy children. However, night-to-night variability of sleep in parents has not previously been considered. This study compared the sleep patterns of parents of ventilator-assisted children (VENT) and healthy, typically developing children (HEALTHY), and examined the relationship between sleep variability and perceived HRQoL. Methods: Seventy-nine mothers and 33 fathers from 42 VENT families (n = 56) and 40 HEALTHY (n = 56) families completed the SF-36 and wore an actigraph for 2 weeks. Reported bedtime and wake time, along with actigraphic total sleep time (TST), wake after sleep onset (WASO), and sleep effi ciency (SE) were examined using both average values and night-tonight instability (mean square successive differences A dvances in medical technology have resulted in more ventilator-assisted children being discharged from the hospital to the home, 1,2 with over 8,000 children in the United States requiring mechanical ventilation.3 Caring for a child with a chronic illness goes above and beyond normal parenting, adding frequent medical procedures, medication administration, and illness specifi c stressors (e.g., medical appointments, dealing with insurance). Parents of children with chronic illnesses have higher rates of depression and anxiety , 4-11 poorer physical health and shorter life expectanc y, 12,13 as well as signifi cantly worse health related quality of life (HRQo L).14-17 Furthermore, shortened or disrupted sleep (from nocturnal caregiving responsibilities or stress related to the child's health) has been repor ted, 16,[18][19][20][21] with associations found between HRQoL and s leep.14-16 However, previous studies have not included an objective measure of sleep patterns, relying instead on subjective reports, which can be biased (caregiver reporting on their own quality of sleep and quality of life). In addition, few studies have quantitatively assessed the sleep and health of parents with ventilator-assisted children.Unpredictable and variable nocturnal caregiving also contributes to erratic sleep patterns. For families of ventilatorassisted children, many of whom have limited (if any) night nursing su pport, 19,22-24 parents may be required to be alert throughout the night on some nights, but not others. This study has shown that in families with ventilator-assisted children, parent sleep is not only shorter, but more variable. Further, the instability in sleep patterns was signifi cantly related to multiple aspects of HRQOL. Because of the high demands places on parental caregivers in terms of medical care for their children, increased support, including nursing and/or respite care, is needed to improve the quantity and quality of parent sleep.