Factors associated with severity of symptoms in patients with chronic unexplained muscular aching.

Kolar, Edward; Hartz, Arthur J.; Roumm, Alan; Ryan, Lisa; Jones, Reece; Kirchdoerfer, E

doi:10.1136/ard.48.4.317

Cited by 12 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sleep disturbances appear to be related to the presence of somatic symptoms, but not to personality (Kolar, Hartz, Roumm, Ryan, & Jones, 1989). The impact of the disease on daily life, as measured by the FIQ, was unrelated to personality in our study.…”

Section: Discussioncontrasting

confidence: 66%

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Montoro

Paso

2015

Personality and Individual Differences

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 66%

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Montoro

Paso

2015

Personality and Individual Differences

View full text Add to dashboard Cite

Fibromyalgia, Sleep Disorder and Chronic Fatigue Syndrome

Moldofsky

2007

Ciba Foundation Symposium 173 ‐ Chronic Fatigue Syndrome

View full text Add to dashboard Cite

Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α₂‐adrenergic receptors

Bennett

Clark

Campbell

et al. 1991

Arthritis & Rheumatism

View full text Add to dashboard Cite

Twenty-nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective documentation of coldinduced vasospasm was obtained by a Nielsen test. Twelve patients (41 %) had abnormal Nielsen test results, and 11 patients (38%) had elevated levels of platelet a2-adrenergic receptors. There was a positive correlation between the percentage of change in finger systolic pressure on cooling (Nielsen test) and the number of qadrenergic receptors. There was poor correlation between Raynaud's syndrome symptoms and an abnormal Nielsen test result. Digital photoplethysmography showed a normal waveform in 2 of 3 patients. We hypothesize that a subgroup of patients with fibromyalgia syndrome have an up-regulation of a2-adrenergic receptors as a cause of their exaggerated reaction to cold. Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue; its pathogenesis is unknown. Despite the lack of any objective laboratory tests, it is frequently diagnosed in North American patients (1,2), and it is gaining increasing recognition in European populations (3,4). The recent publication of the American College of Rheumatology (ACR) diagnostic criteria should provide a uniform standard for future clinical studies (5). Although the current definition of fibromyalgia is disarmingly simplewidespread body pain and >9 (of 18) tender pointsmany patients have symptoms that are not related to the musculoskeletal system, such as irritable bowel, dry eyes, dry mouth, tinnitus, imbalance, and Raynaud's phenomenon (6). Symptoms suggestive of Raynaud's syndrome have been described in 30-53% of patients (73). We report here the quantitative measurement of cold-induced vasospasm and its association with an increased number of platelet aZadrenergic receptors in patients with fibromyalgia. PATIENTS AND METHODS Study population.Consecutive female patients attending the Rheumatology Clinic at the Oregon Health Sciences University (OHSU) were invited to participate in this study. Of the first 30 asked, 29 agreed to participate. All patients fulfilled previous criteria for a diagnosis of fibromyalgia (9). In retrospect, they would also have met the 1990 criteria published by the ACR (5). The demographics of the patients are shown in Table 1 .The normal control subjects for the digital hypothermic challenge test (Nielsen test) were all female staff at OHSU. Their mean ( t S D ) age was 42.9 2 5.9 years. These subjects did not have fibromyalgia or symptoms of Raynaud's phenomenon, nor were they currently using tobacco or other vasoactive substances. Controls for the

show abstract

Factors associated with severity of symptoms in patients with chronic unexplained muscular aching.

Cited by 12 publications

References 8 publications

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Fibromyalgia, Sleep Disorder and Chronic Fatigue Syndrome

Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α₂‐adrenergic receptors

Contact Info

Product

Resources

About

Factors associated with severity of symptoms in patients with chronic unexplained muscular aching.

Cited by 12 publications

References 8 publications

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Personality and fibromyalgia: Relationships with clinical, emotional, and functional variables

Fibromyalgia, Sleep Disorder and Chronic Fatigue Syndrome

Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α2‐adrenergic receptors

Contact Info

Product

Resources

About

Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α₂‐adrenergic receptors