Factors Associated with Severe Disease in a Population of Asthmatic Children of Bogota, Colombia

Martínez, Carlos Rodríguez; Sossa, Monica P.; Goss, Christopher H.

doi:10.1080/02770900701840253

Cited by 16 publications

(10 citation statements)

References 46 publications

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“…In our prospective study, we found that antibiotics per se were not risk factors for asthma or atopy at 5 yrs [21]. In another study, 2-16-yrold children attending an asthma clinic who used acetaminophen for fever in the preceding 12 months had increased risk of severe asthma [22]. No information was available on the causes of fever.…”

Section: Discussionmentioning

confidence: 65%

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

Kusel

Kebadze²,

Johnston³

et al. 2011

Eur Respir J

107

145

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Severe viral respiratory illnesses and atopy are risk factors for childhood wheezing and asthma. The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with wheeze and asthma persisting into later childhood.147 children at high atopic risk were followed from birth to age 10 yrs. Data on all respiratory infections occurring in infancy were collected prospectively and viral aetiology ascertained. Atopy was measured by skin prick tests at 6 months, and 2 and 5 yrs. History of wheeze and doctordiagnosed eczema and asthma was collected regularly until 10 yrs of age.At 10 yrs, 60% of the cohort was atopic, 25.9% had current eczema, 18.4% current asthma and 20.4% persistent wheeze. 35.8% experienced at least one lower respiratory infection (LRI) associated with fever and/or wheeze in first year of life. Children who had wheezy or, in particular, febrile LRI in infancy and were atopic by 2 yrs, were significantly more likely to have persistent wheeze (RR 3.51, 95% CI 1.83-6.70; p,0.001) and current asthma (RR 4.92, 95% CI 2.59-9.36; p,0.001) at 10 yrs.Severe viral respiratory infections in infancy and early atopy are risk factors for persistent wheeze and asthma. The strongest marker of the asthmatogenic potential of early life infections was concurrent fever. The occurrence of fever during respiratory illnesses is an important marker of risk for wheeze and asthma later in childhood, suggesting it should be measured in prospective studies of asthma aetiology.

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Section: Discussionmentioning

confidence: 65%

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

Kusel

Kebadze²,

Johnston³

et al. 2011

Eur Respir J

107

145

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“…Patients whose fathers have less than a high school education (<9 years of schooling) are more likely to have persistent asthma. In contrast, one study in Columbian children demonstrated that lower maternal education was an independent predictor of severe asthma (7). Paternal educational level was not investigated by that study.…”

Section: Discussionmentioning

confidence: 83%

“…Non-Caucasian race, male gender, early onset of the disease, family history of asthma, exposure to tobacco smoke or dust, lack of breastfeeding, lower maternal education, and allergen sensitization were shown to be associated with more severe childhood asthma (5)(6)(7)(8)(9). However, most of these factors were investigated only by one or two studies and further studies are needed to confirm these results.…”

Section: Introductionmentioning

confidence: 68%

“…Early onset of the disease as the predicator of more severe childhood asthma has been shown by one (6) but not the other previous study (7). The first 2 years of life is a critical period for lung development and the lungs are more susceptible to both internal and external injuries (12).…”

Section: Discussionmentioning

confidence: 95%

“…All variables with p-value <.2 in bivariate analysis were entered into the logistic regression model. We also selected some potentially relevant variables to be entered into the model based on previous reports (5)(6)(7)(8) and clinical judgment, such as race, gender, maternal education, presence of household pets, family history of asthma, personal history of atopy, maternal smoking, breastfeeding, obesity, and regular consumption of fish, eggs, vegetables, and fruits in the last 30 days. A Hosmer-Lemeshow test was used to assess the goodness of fit of the final model (11).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Factors Associated with Asthma Severity in Children: A Case–Control Study

et al. 2011

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Early‐life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma

Dietert

Zelikoff

2008

Birth Defects Research Pt B

108

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Incidence of childhood allergic disease including asthma (AD-A) has risen since the mid-20th century with much of the increase linked to changes in environment affecting the immune system. Childhood allergy is an early life disease where predisposing environmental exposures, sensitization, and onset of symptoms all occur before adulthood. Predisposition toward allergic disease (AD) is among the constellation of adverse outcomes following developmental immunotoxicity (DIT; problematic exposure of the developing immune system to xenobiotics and physical environmental factors). Because novel immune maturation events occur in early life, and the pregnancy state itself imposes certain restrictions on immune functional development, the period from mid-gestation until 2 years after birth is one of particular concern relative to DIT and AD-A. Several prenatal-perinatal risk factors have been identified as contributing to a DIT-mediated immune dysfunction and increased risk of AD. These include maternal smoking, environmental tobacco smoke, diesel exhaust and traffic-related particles, heavy metals, antibiotics, environmental estrogens and other endocrine disruptors, and alcohol. Diet and microbial exposure also significantly influence immune maturation and risk of allergy. This review considers (1) the critical developmental windows of vulnerability for the immune system that appear to be targets for risk of AD, (2) a model in which the immune system of the DIT-affected infant exhibits immune dysfunction skewed toward AD, and (3) the lack of allergy-relevant safety testing of drugs and chemicals that could identify DIT hazards and minimize problematic exposure of pregnant women and children.

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Factors Associated with Severe Disease in a Population of Asthmatic Children of Bogota, Colombia

Cited by 16 publications

References 46 publications

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

Factors Associated with Asthma Severity in Children: A Case–Control Study

Early‐life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma

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