Factors associated with serum retinol, α-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use

Forrester, Janet E.; Wang, Xiang D; Knox, Tamsin A.; Borek, Carmia; Tang, Alice; Johnson, Elizabeth J.

doi:10.1057/jphp.2009.20

Cited by 10 publications

(12 citation statements)

References 33 publications

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“…11 Several other studies have also found that HIV infection is associated with reduced serum selenium concentrations. 8,9,[13][14][15] Indeed, nutritional deficiencies are common among individuals with HIV infections 16 The present study did not find any association between selenium deficiency and maternal mortality. This observation is at variance with studies into HIV-related mortality carried out among nonpregnant HIV-infected participants, 18,19 but was similar to the findings of two selenium supplementation trials 20,21 carried out among pregnant women with HIV infections.…”

Section: Discussioncontrasting

confidence: 51%

“…The cutoff value chosen by Shivakoti et al (1.08 μmol/L [85 μg/L]) was based on previous studies of HIV and selenium status [12], whereas the present cutoff value (0.89 μmol/L [70 μg/L]) was based on the lower limit of the reference range for normal selenium levels in a standard clinical chemistry textbook [11]. Several other studies have also found that HIV infection is associated with reduced serum selenium concentrations [8,9,13–15]. Indeed, nutritional deficiencies are common among individuals with HIV infections [16] because of factors such as the oxidative state induced by the virus, malabsorption, metabolic alterations, gut infections, and gut barrier dysfunction produced by chronic HIV infection [17].…”

Section: Discussionmentioning

confidence: 99%

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Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria

Okunade

Olowoselu

Osanyin

et al. 2018

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria

Okunade

Olowoselu

Osanyin

et al. 2018

Intl J Gynecology & Obste

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“…In contrast with our study, several cross-sectional studies have reported a significant association between low selenium concentrations and HIV infection (24)(25)(26)(27)(28). In these reports, various mechanisms have been postulated for the selenium deficiency observed, including inadequate intake, malabsorption, or overutilization and depletion of selenium that prevents adequate restoration (3,4).…”

Section: Discussioncontrasting

confidence: 99%

Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults

Hileman

Dirajlal-Fargo

Lam

et al. 2015

The Journal of Nutrition

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Plasma selenium concentrations were within the normal range for the background population and were not associated with subclinical vascular disease in HIV-infected adults on contemporary ART. The association between current PI use and higher selenium may have implications for ART allocation, especially in resource-limited countries. Also, it appears that statin therapy may increase selenium concentrations; however, larger studies are necessary to confirm this finding. This trial was registered at clinicaltrials.gov as NCT01218802.

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“…In a cohort of previous nonresponder patients with HCV chronic infection,9 all‐transretinoic‐acid (ATRA) demonstrated a direct antiviral and a strong additive or synergistic effect with pegylated IFN. Nevertheless, only few studies are available regarding the prevalence of vitamin A deficiency in HCV chronically infected patients10, 11; furthermore, the potential effect of vitamin A in modifying the antiviral action of IFN and ribavirin has never been studied.…”

mentioning

confidence: 99%

Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy

et al. 2013

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Recent data suggest that vitamin A modulates the expression of type I interferon receptor enhancing the antireplication effect of interferon-a on hepatitis C virus (HCV). This study aimed to investigate the prevalence of vitamin A deficiency among patients with chronic HCV infection and to assess whether vitamin A deficiency could be associated with unresponsiveness to interferon-based antiviral therapy. The analysis included 199 consecutive treatment-naïve chronic HCV patients in whom pretreatment serum vitamin A and 25-OH vitamin D were measured; 119 healthy blood donors were used as controls. Median (interquartile range) serum vitamin A in HCV-positive patients was significantly lower than in controls: 256 ng/mL (128-440) versus 742 (624-942, P < 0.0001). Overall sustained viral response was achieved in 122/199 patients, 46/109 infected by difficult to treat HCV genotypes. In these latter, 39/104 (37.5%) were nonresponders. At multivariate analysis, nonresponse to antiviral therapy was predicted by carriage of interleukin (IL)-28B T/* genotypes, baseline serum levels of cGT >60 IU/mL, of HCV RNA >600,000 IU/mL, of vitamin A 100 ng/mL, and a cumulative dose of ribavirin 80%. Seventeen patients (9.0%) had both serum levels of vitamin A 100 ng/mL and of vitamin D 20 ng/mL; the presence of a combined vitamin A and D deficiency was found to be a strong independent predictor of nonresponse to antiviral therapy. Conclusion: A high percentage of patients with chronic HCV infection have serum vitamin A deficiency. This condition is associated with nonresponse to antiviral therapy. (HEPATOLOGY 2013;00:000-000)

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Factors associated with serum retinol, α-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use

Cited by 10 publications

References 33 publications

Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria

Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria

Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults

Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy

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