Factors associated with serum antibodies to reticulin, endomysium, and gliadin in an adult population.

McMillan, S. A.; Watson, Rgp; McCrum, Evelyn; Evans, Alun

doi:10.1136/gut.39.1.43

Cited by 65 publications

(38 citation statements)

References 18 publications

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“…TRONCONE et al (64) called attention to slight dietary transgressions and a negative test, mainly in adolescents. Our results show that EmA was 100% positive for untreated patients and for celiacs non-adhering to the diet and disagree with those reported by McMILLAN et al (50) who found that 89% of their patients with untreated celiac disease had a positive EmA measured by immunofluorescence. However, FERREIRA et al (26) showed 100% positivity to EmA for untreated celiac disease in a predominantly adult population similar to that studied here.…”

Section: Considerations About Emacontrasting

confidence: 57%

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Utiyama

et al. 2001

Arq. Gastroenterol.

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Section: Considerations About Emacontrasting

confidence: 57%

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Utiyama

et al. 2001

Arq. Gastroenterol.

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“…Only in 1 of these patients did we find a laboratory result which could further support the suspicion of latent CD: in fact, he showed positive serum AGA results; however, it must be remembered that the MONICA study, in Belfast, revealed that 5.7% of the general population showed positive serum AGA [16], thus indicating a relatively high frequency of false-positive AGA results.…”

Section: Discussionmentioning

confidence: 99%

Tissue Transglutaminase Autoantibodies in Patients with Non-Hodgkin’s Lymphoma

Carroccio¹,

Fabiani

Iannitto

et al. 2000

Digestion

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Background: Tissue transglutaminase (tTG) has recently been identified as the autoantigen recognized by endomysial antibodies in celiac disease (CD) patients and this has permitted the use of an ELISA test to detect the presence in the serum of autoantibodies specific for the diagnosis of CD. Aim: We report two cases of anti-tTG positivity in patients with non-Hodgkin’s lymphoma (NHL) without evidence of CD. Case Reports: Both patients were males aged 67 and 69 years respectively; both were hospitalized for fever and peripheral adenopathy. Lymph node histology showed an immunoblastic high-grade T-cell NHL at the IVth the stage of disease in both cases. They were included in a multicenter study on the association between CD and NHL. Serological screening for CD showed the presence of serum anti-tTG antibodies, with values within the range of those recorded in untreated CD patients in our laboratory; however, both patients had negative anti-endomysial antibodies and in both cases intestinal histology showed normal mucosa with villi and crypts of normal height and depth (villi/crypts ratio ≥2.5, within the range of normal subjects for our laboratory), and no increase in intraepithelial lymphocytes. The HLA phenotype was obtained giving the following antigens: Case 1: A 3, A 24(9), B 22, B 35, BW 6, DR 1, DR 11(5), DQ 3, DR 52. Case 2: A 2, A 3, B 51(5), B 8, BW 4, BW 6, DR B1*02, DR B1*03, DR B3*01. Both subjects were also positive for serum anti-smooth muscle antibodies and one for antinuclear antibodies. Conclusions: (1) Serum anti-tTG positivity can be found in subjects with NHL without CD and the real frequency of these ‘false positives’ must be investigated both in subjects with lymphoproliferative disorders and in patients with autoimmune diseases. (2) In patients with NHL, without CD, anti-tTG positivity may be unassociated with EmA positivity and the biological significance of this finding must be clarified.

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“…Monosymptomatic, oligosymptomatic, atypical, silent and latent types of CD have been identified (4,35) as CD today often presents atypically, it is underdiagnosed. It is recommended that the detection rate might be improved by 12% when serology is employed to determine cases of occult enteropathy (38,46) . Serologic antibody tests are indicated for all people in whom celiac disease is (even remotely) presumed, and also for all persons considered to be at risk for the disease (33) .…”

Section: Introductionmentioning

confidence: 99%

“…CD was historically believed an intestinal disorders of childhood and adult life, characterised by failure to thrive, malabsorption, diarrhea, weight loss, vomiting, unusual stools, and also abdominal distention (12,38) . On the other hand, only some patients with CD exhibit clinical symptoms, while most of the patients have slight symptoms (19) .…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

Baghbanian

Farahat

Vahedian

et al. 2015

Arq. Gastroenterol.

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-Background -Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. Objective -To investigate correlation between tTg levels and histological alterations and then to determine the prevalence of celiac disease in Center and South area patients of Iran with iron deficiency anemia. Methods -A total of 402 patients aged 12-78 years who presented with iron-deficiency anemia were included in this study. Hemoglobin, mean corpuscular volume and serum ferritin were determined. Venous blood samples for anti-tissue transglutaminase antibody immunoglobuline A and G were obtained from these patients. Upper gastrointestinal endoscopy was recommended to patients who had positive serology.

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Factors associated with serum antibodies to reticulin, endomysium, and gliadin in an adult population.

Cited by 65 publications

References 18 publications

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Tissue Transglutaminase Autoantibodies in Patients with Non-Hodgkin’s Lymphoma

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

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