‘Factors associated with serious skin reactions in children aged 12 years and under taking lamotrigine’

Besag, Frank; McShane, Tony; Neville, Brian; Robinson, Richard

doi:10.1111/j.1469-8749.1999.tb00014.x

Cited by 2 publications

(1 citation statement)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential for drug–drug interactions between AEDs is an important consideration in cases in which patients require multiple agents for optimal seizure control. For example, phenytoin (PHT) and carbamazepine (CBZ) are both substrates, and inducers, of cytochrome P450‐3A and have high potential for interaction, whereas valproate (VPA) can increase risk of rash with lamotrigine (LTG) (22–25). The present studies were undertaken to describe the plasma pharmacokinetics of PGB in patients with partial epilepsy maintained on individualized monotherapy with commonly used AEDs, including CBZ, VPA, LTG, and PHT.…”

mentioning

confidence: 99%

Pregabalin Drug Interaction Studies: Lack of Effect on the Pharmacokinetics of Carbamazepine, Phenytoin, Lamotrigine, and Valproate in Patients with Partial Epilepsy

et al. 2005

View full text Add to dashboard Cite

Summary:Purpose: Pregabalin (PGB) is an α 2 -δ ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety disorders. PGB is highly efficacious as adjunctive therapy in patients with refractory partial seizures.Methods: Given its efficacy as adjunctive therapy, the potential for interaction of PGB with other antiepileptic drugs (AEDs) was assessed in patients with partial epilepsy in open-label, multipledose studies. Patients received PGB, 600 mg/day (200 mg q8h) for 7 days, in combination with their individualized maintenance monotherapy with valproate (VPA), phenytoin (PHT), lamotrigine (LTG), or carbamazepine (CBZ).Results: Trough steady-state concentrations of CBZ (and its epoxide metabolite), PHT, LTG, and VPA were unaffected by concomitant PGB administration. Likewise, PGB steady-state pharmacokinetic parameter values were similar among patients receiving CBZ, PHT, LTG, or VPA and, in general, were similar to those observed historically in healthy subjects receiving PGB alone. The PGB-AED combinations were generally well tolerated. PGB may be added to VPA, LTG, PHT, or CBZ therapy without concern for pharmacokinetic drug-drug interactions.

show abstract

mentioning

confidence: 99%