Factors Associated With Second-Trimester Pregnancy Loss in Women With Normal Uterine Anatomy Undergoing In Vitro Fertilization

Bressler, Leah Hawkins; Correia, Katharine F.; Srouji, Serene S.; Hornstein, Mark D.; Missmer, Stacey A.

doi:10.1097/aog.0000000000000667

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…It is possible that, rather than the fertility treatment itself, differences between subfertile women who undergo IVF/ICSI and fertile women who conceive naturally may influence the pregnancy risk, as was previously suggested in large cohorts of singletons and twins 5,7,16 . Furthermore, late miscarriage after IVF is associated with the presence of leiomyomas and increased body mass index, two factors that could also play a role in decreased fertility 38 . It would be interesting to examine the effects of smoking, body mass index, diabetes, hypertension, hormonal imbalances and other factors on the outcome of MCDA twins; unfortunately, as this was a retrospective study, we relied on ultrasound records that do not routinely include this information.…”

Section: Discussionmentioning

confidence: 99%

Monochorionic twins after in‐vitro fertilization: do they have poorer outcomes?

Couck

Nylen

Deprest

et al. 2020

Ultrasound in Obstet & Gyne

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Objective To compare the outcome of monochorionic diamniotic (MCDA) twin pregnancies conceived by in‐vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with that of spontaneously conceived MCDA twins. Methods This was a retrospective cohort study of MCDA twin pregnancies conceived after IVF/ICSI or spontaneously, followed from the first trimester onwards at a single center between January 2002 and September 2018. The primary outcome was survival per fetus from the first trimester until 28 days after birth. Secondary outcome measures were number of survivors, miscarriage, termination of pregnancy, intrauterine and neonatal death, major congenital anomalies, twin–twin transfusion syndrome, selective fetal growth restriction, gestational age at birth, delivery before 32 weeks' gestation, mode of delivery, admission to the neonatal intensive care unit, birth weight and birth‐weight discordance. Results Of the 654 MCDA pregnancies included in the analysis, 80 were conceived by IVF/ICSI and 574 spontaneously. Overall fetal and neonatal survival was significantly lower in the IVF/ICSI group than in the spontaneous‐conception group (79% vs 90%; P = 0.001). In the IVF/ICSI group, compared with the spontaneous‐conception group, loss of one or both twins occurred twice as often (29% vs 14%; P = 0.001) and there was a higher risk of second‐trimester miscarriage (8% vs 1%; P = 0.002). Conclusions MCDA twins conceived after IVF/ICSI have lower overall survival rates and higher rates of second‐trimester miscarriage than do spontaneously conceived MCDA twins. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Discussionmentioning

confidence: 99%

Monochorionic twins after in‐vitro fertilization: do they have poorer outcomes?

Couck

Nylen

Deprest

et al. 2020

Ultrasound in Obstet & Gyne

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“…[6] Obese women have 2-fold greater odds of pregnancy loss than normal-weight women. [7] Obese women also have adverse pregnancy outcomes with assisted reproductive technology, including a lower clinical pregnancy rate, lower live birth rate, and higher miscarriage rate. [8] Weight loss can improve spontaneous ovulation and increase the spontaneous pregnancy rate.…”

Section: Introductionmentioning

confidence: 99%

The impact of weight loss for obese infertile women prior to in vitro fertilization: A retrospective cohort study

Shen

Fang

et al. 2023

Medicine

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Obesity is detrimental to general health and also reproductive health. This study aimed to evaluate whether weight reduction in obese infertile women prior to in vitro fertilization reduces the total gonadotropin dose and improves pregnancy outcomes. This retrospective cohort study was performed at the Jiaxing Maternity and Child Health Care Hospital between January 2017 and January 2022, and 197 women were enrolled. The women were divided into 2 groups according to the weight loss goal of 5%: weight reduction group A (≥weight loss goal of 5%) and control group A (

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