Factors associated with respiratory distress syndrome in preterm neonates admitted to a tertiary hospital in Kabul city: A retrospective cross-sectional study

Aslamzai, Mansoor; Froogh, Basir Ahmad; Mukhlis, Abdul Hakim; Faizi, Omid; Sajid, Sayed Azam; Hakimi, Zmaryalai

doi:10.1016/j.gpeds.2023.100035

Cited by 5 publications

(7 citation statements)

References 22 publications

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“…In agreement with studies conducted in Taiwan,12 Afghanistan,18 Saudi Arabia21 and China,27 prematurity is a predictor of RDS. This is explained by due to inadequate surfactant production or inactivation of surfactant in the context of immature lungs.…”

Section: Discussionsupporting

confidence: 90%

“…The second possible explanation could be in those studies the magnitude of maternal morbidity such as DM, and pre-eclampsia/eclampsia was high 23 42. In addition, in those studies, congenital anomalies were high in percentage, whereas in the present study, it was low 18…”

Section: Discussioncontrasting

confidence: 45%

“…42 In contrast to the aforementioned studies, the present study was lower than studies conducted in Iran 76%, 17 Taiwan 60%-86.5%, 11 12 Thailand 70.7%, 14 Finland 76% 13 and Afghanistan 58.8%. 18 This marked difference might be attributed to study subject recruitment criteria, because those studies include only very LBW and very preterm neonates, so due to anatomical and physiological organ immaturity the probability of RDS could be high. 33 42 Whereas, the present study includes all categories of LBW and all categories of gestational age.…”

Section: Discussionmentioning

confidence: 99%

“…The magnitude of RDS among LBW neonates varies across countries depending on the availability of medical services and the number of trained medical personnel. For instance, in Taiwan 60%–86%,11 12 Finland 76%,13 Thailand 70.7%,14 Karachi, Pakistan 11%–12.8%,15 16 Iran 76%,17 Afghanistan 58.8%18 and in Nigeria 10.9%19 of LBW neonates had RDS. In Ethiopia, RDS is the primary cause of admission with a mortality rate of 45.3% among LBW neonates 20.…”

Section: Introductionmentioning

confidence: 99%

“…These studies showed that different factors increase the risk of RDS among LBW neonates. Accordingly, maternal Diabetes Mellitus (DM),21–23 hypertension,21 mode of delivery,18 21 22 24 sex,12 18 21 22 24 prematurity,12 18 21 22 multiparity24 birth weight,12 18 22 antenatal steroid,12 25 hyperglycaemia,26 sepsis,18 Antepartum Paemorrhage (APH),18 Premature Rupture of Membrane (PROM),18 27 first and fifth minute ((Appearance, Pulse, Grimace, Activity, Respiration) (APGAR)) score28 were significant predictors of RDS.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and predictors of respiratory distress syndrome among low birth weight neonates in the first seven days in Northwest Ethiopia Comprehensive Specialized Hospitals, 2023: A retrospective follow-up study

Wondie,

Legesse,

Mekonnen

et al. 2023

BMJ Open

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IntroductionRespiratory distress syndrome is a catastrophic respiratory problem among low birth weight neonates. It increases the suffering of neonates and the economic expenditure of the countries. Notably, it is a major public health issue in low-income and middle-income countries such as Ethiopia. Despite this, studies regarding respiratory distress syndrome among low birth weight neonates were limited in Ethiopia.ObjectiveTo assess the incidence and predictors of respiratory distress syndrome among low birth weight neonates in the first 7 days in Northwest Ethiopia Comprehensive Specialized Hospitals.MethodMulticentred institution-based retrospective follow-up study was conducted from 19 September 2021 to 1 January 2023, among 423 low birthweight neonates. A simple random sampling technique was used. The data were collected using a data extraction checklist from the medical registry of neonates. The collected data were entered into EPI-DATA V.4.6.0.6. and analysed using STATA V.14. The Kaplan-Meier failure curve and log-rank test were employed. Bivariable and multivariable Weibull regression was carried out to identify predictors of respiratory distress syndrome. Statistical significance was declared at a p≤0.05.ResultThe incidence rate of respiratory distress syndrome was found to be 10.78 (95% CI 9.35 to 12.42) per 100 neonate days. Fifth minute Appearance, Pulse, Grimace, Activity, Respiration (APGAR score) <7 (AHR 1.86; 95% CI 1.18 to 2.92), multiple pregnancy (AHR 1.43; 95% CI 1.04 to 1.96), caesarean section delivery (AHR 0.62; 95% CI 0.41 to 0.93), prematurity (AHR 1.56; 95% CI 1.06 to 2.30) and birth weight <1000 g (AHR 3.14; 95% CI 1.81 to 5.40) and 1000–1499 g (AHR 2.06; 95% CI 1.42 to 2.83) were significant predictors.ConclusionThe incidence of respiratory distress syndrome was higher than other studies conducted on other groups of neonates. Multiple pregnancy, fifth minute APGAR score, caesarean section, prematurity, extremely low birth weight and very low birth weight were predictors of respiratory distress syndrome. However, it needs further prospective study. Therefore, the concerned stakeholders should give due attention and appropriate intervention for these predictors.

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