Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis

Chen, Hung An; Chen, Chun Hsiung; Liao, Hsien Tzung; Lin, Yeong Jang; Chen, Pei Chih; Chen, Wei Sheng; Chou, Chung Tei

doi:10.1016/j.semarthrit.2010.07.008

Cited by 64 publications

(57 citation statements)

References 13 publications

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“…29,30 In our study, US-CRP levels were higher in patients with SpA as compared to healthy controls, showing a correlation with the presence of factors of poor prognosis. In AS, only 40%-60% of the patients have elevated.…”

Section: Discussionsupporting

confidence: 55%

Associação entre os níveis séricos de potenciais biomarcadores com a presença de fatores relacionados à atividade clínica e ao mau prognóstico em espondiloartrites

Londoño¹,

Romero-Sánchez²,

Torres³

et al. 2012

Rev. Bras. Reumatol.

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Background: Serum biomarkers traditionally associated with infl ammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. Methods: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, infl ammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α, TNF-α, IFN-γ, and IL-23. Results: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, infl ammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α, IL-6, IL-1α, and US-CRP levels were signifi cantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, infl ammatory back pain, and arthritis. Conclusion: An increase in serum levels of US-CRP, IL-6, IL-1α, and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis.

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Section: Discussionsupporting

confidence: 55%

Associação entre os níveis séricos de potenciais biomarcadores com a presença de fatores relacionados à atividade clínica e ao mau prognóstico em espondiloartrites

Londoño¹,

Romero-Sánchez²,

Torres³

et al. 2012

Rev. Bras. Reumatol.

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“…On the other hand, the presence of peripheral arthritis at baseline reportedly did not reveal significant associations with spinal radiographic progression over 2 years in patients with axial SpA [15]. In another study, radiographic spinal joint involvement with fusion was not associated with a history of peripheral arthritis [6]. The previous studies provided equivocal findings and were limited by small sample size.…”

Section: Discussionmentioning

confidence: 87%

“…Several studies have investigated the relationship between peripheral arthritis and radiographic progression in AS [6,8,18]. AS patients with peripheral joint disease may have clinically and radiographically less severe spinal disease course than those without peripheral joint disease [8].…”

Section: Discussionmentioning

confidence: 99%

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The presence of peripheral arthritis delays spinal radiographic progression in ankylosing spondylitis: Observation Study of the Korean Spondyloarthropathy Registry

Kim¹,

Lee²,

Joo³

et al. 2014

Rheumatology

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Objectives. The aim of this study was to determine whether the presence of peripheral arthritis can affect radiographic structural damage in patients with AS.Methods. A total of 915 subjects comprising 363 patients with a history of peripheral arthritis and 552 patients without a history of peripheral arthritis obtained from the Observation Study of the Korean SpA Registry (OSKAR) were analysed looking at the relationship of peripheral arthritis history in a crosssectional survey as well as the radiographic damage score according to the presence or absence of peripheral arthritis. Radiographs and clinical information were available for 501 subjects (205 peripheral arthritis patients and 296 without peripheral arthritis) at a mean follow-up of 2.7 years. The modified Stoke AS Spinal Score (mSASSS) was examined by two experienced radiologists to validate the results. Reliability was evaluated using the intraclass correlation coefficient for each radiograph.Results. The agreement between the two readers regarding the mSASSS was good. On simple comparison there was a significant difference in the mSASSS between patients with a history of peripheral arthritis and those without [mean 14.62 (S.E.M. 0.83) vs 18.78 (0.79), P < 0.001]. The mSASSS change was stratified according to the presence or absence of peripheral arthritis at baseline. After adjusting for multiple comparisons by Bonferroni correction, the patients with peripheral arthritis had less mSASSS change than those without peripheral arthritis [3.08 (S.E.M. 0.61) vs 5.18 (0.47), P = 0.008].Conclusion. The presence of peripheral arthritis delays spinal radiographic progression in AS.

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“…However, there is no evidence that anti-TNF-α agents prevent radiographic progression in patients with AS. In rheumatoid arthritis (RA), anti-TNF-α agents can prevent bone erosion and radiographic progression by suppressing osteoclast activity 2,3 . Unlike new bone formation in the axial spine, synovial inflammation within the hip joint induces bone erosion and subsequent joint destruction 4,5 in AS.…”

Section: To the Editormentioning

confidence: 99%

Radiographic Evidence of Hip Joint Recovery in Patients with Ankylosing Spondylitis after Treatment with Anti-tumor Necrosis Factor Agents: A Case Series

Song¹,

Chung²,

Lee³

2017

J Rheumatol

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Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis

Cited by 64 publications

References 13 publications

Associação entre os níveis séricos de potenciais biomarcadores com a presença de fatores relacionados à atividade clínica e ao mau prognóstico em espondiloartrites

Associação entre os níveis séricos de potenciais biomarcadores com a presença de fatores relacionados à atividade clínica e ao mau prognóstico em espondiloartrites

The presence of peripheral arthritis delays spinal radiographic progression in ankylosing spondylitis: Observation Study of the Korean Spondyloarthropathy Registry

Radiographic Evidence of Hip Joint Recovery in Patients with Ankylosing Spondylitis after Treatment with Anti-tumor Necrosis Factor Agents: A Case Series

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