Factors associated with quality of life of adult patients with acute leukemia and their family caregivers in China: a cross-sectional study

Abstract

Background: Acute leukemia (AL) not only impairs the quality of life (QOL) of patients, but also affects that of their family caregivers (FCs). Studies on QOL of AL patients and their FCs are limited. This study aimed to evaluate the QOL of AL patients and their FCs, and to explore the factors associated with QOL of patients and of FCs. Methods: A multicenter cross-sectional study was conducted. The QOL of 196 patient-FC dyads was assessed. The Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) was used for patients, and the 36-item Short-Form Health Survey (SF-36) was used for FCs. Independent-samples t-tests or one-way analysis of variance were used to compare QOL subscale scores between groups with different sociodemographic/clinical characteristics. Multiple regression analysis was conducted to identify the factors associated with QOL of AL patients and their FCs. Results: The total FACT-Leu score for AL patients was 76.80 ± 16.44, and the physical component summary (PCS) and mental component summary (MCS) scores for FCs were 64.67 ± 15.44 and 52.50 ± 13.49, respectively. All QOL subscales for patients (t = 12.96-34.73, p < 0.001) and FCs (t = 2.55-14.36, p < 0.05), except role emotional (t = − 0.01, p = 0.993), were lower than those reported in previous studies. Sex, employment, and chemotherapy were significantly associated with total FACT-Leu score in AL patients (p < 0.05). Age, sex, marital status, education, employment, and relationship to patients were significantly associated with SF-36 PCS or MCS (p < 0.05). Conclusions: AL patients and their FCs both have lower QOL than the population in previous studies. These findings suggest that not only AL patients' physical and mental health but also overall family QOL should be assessed. Interventions supporting patient-FC dyads should be developed to improve their QOL.

Unmet supportive care needs and its relation to quality of life among adult acute leukaemia patients in China: a cross-sectional study

“…Today, more attention is being paid to meeting the needs of patients suffering from other types of cancer, such as prostate and breast cancer, in order to improve cancer patients' QoL [18,19]. Previous studies have shown that patients with AL have a low QoL [20].…”

Literatur Review : Kualitas Hidup Pasien Leukemia

“…Lingkungan mempunyai dampak yang cukup signifikan terhadap kualitas hidup pasien. Dimana lingkungan tersebut merupakan salah satu sarana untuk beraktivitas pasien, sehingga sangat memperngaruhi kondisi fisik dan psikologis pasien (Wang et al, 2020). Perubahan peran sosial yang terjadi pada saat pasien sakit akan membawa dampak tersendiri bagi pasien tersebut, sehingga bisa mengakibatkan depresi dan ansietas.…”

Effectiveness of a Need-Based Program in Relieving Psychological Distress of Family Caregivers of Leukemia Patients: A Randomized Clinical Trial

“…Extensive research has been conducted into identifying the health-care needs of family caregivers and the effects of the cancer diagnosis on patients' families [8,9]; however, few experimental studies have been undertaken according to family caregivers' attitude and need, speci cally and functionally to address the psychological distress experienced by the family caregivers of leukemia patients [10]. Regarded that whilst SEER data indicate very limited increase with time from 1975 to 2017 for all types of leukemias, and estimated new cases in 2020 in the USA were 60,530 all types with a moderate increase in ALL and AML from 1992 to 2017 [11], the annual new incidence rate for leukemia has been estimated to range from 0.1 to 1.5 per 100,000 individuals and the prevalence of this disease has been estimated to be 24 per 100,000 people over the world [12].…”