Factors associated with prolonged symptoms and severe disease due to Clostridium difficile

Kyne, Lorraine; Merry, Concepta; O’Connell, Brian; Kelly, Adrienne; Keane, C. T.; O’Neill, Desmond

doi:10.1093/ageing/28.2.107

Cited by 129 publications

(83 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously published CDAD severity grading systems were developed on the basis of outcomes and characteristics seen in patients with CDAD throughout their clinical course. 14,15 The grading system presented herein was developed on the basis of clinical presentation (symptoms present within 48 hours before or after CDAD diagnosis). Application of this system identified patients at increased risk for adverse events associated with CDAD.…”

Section: Resultsmentioning

confidence: 99%

Severity of Clostridium difficile–Associated Disease (CDAD) in Allogeneic Stem Cell Transplant Recipients: Evaluation of a CDAD Severity Grading System

Dubberke

Sadhu

Gatti

et al. 2007

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Severity of Clostridium difficile–Associated Disease (CDAD) in Allogeneic Stem Cell Transplant Recipients: Evaluation of a CDAD Severity Grading System

Dubberke

Sadhu

Gatti

et al. 2007

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

“…If the patient has recurrent CDAD (with more than two previous episodes), the frequency of further recurrences increases dramatically (50-65 %). Repeated antibiotic courses may eventually cure the patient of recurrent CDAD, but this can require months or even years of antibiotic treatment Kyne et al, 1999;McFarland et al, 1999;Barbut et al, 2000).…”

Section: Standard Antibiotic Treatmentsmentioning

confidence: 99%

Alternative treatments for Clostridium difficile disease: what really works?

McFarland

2005

Journal of Medical Microbiology

141

View full text Add to dashboard Cite

Vancomycin and metronidazole have been used for treating Clostridium difficile-associated disease (CDAD) for the past 25 years, but approximately 20 % of patients develop recurrent disease. The increasing incidence of nosocomial outbreaks, cases of recurrent CDAD and other complications (toxic megacolon, ileus, sepsis) has fuelled the search for different types of treatments. As the understanding of the pathogenesis of this disease has matured, newer treatment strategies that take advantage of these mechanisms have been developed. This review will describe such treatments and examine the evidence for each strategy.

show abstract

“…Al igual que en esta investigación, diversos estudios (3,4,16,22,23) han documentado que esta enfermedad afecta a todos los grupos poblacionales sin distinción de edad ni de sexo, aunque parece presentarse con mayor frecuencia en los adultos mayores de 65 años, en quienes, además, es más agresiva (3,12,22,24).…”

Section: Discussionunclassified

Clinical and demographic profile and risk factors for Clostridium difficile infection

Carvajal¹,

Pacheco²,

Jaimes³

2017

biomedica

View full text Add to dashboard Cite

Contribución de los autores:Todos los autores participaron en igual medida en todos los aspectos del estudio y la redacción del manuscrito. Introducción. La enfermedad asociada a Clostridium difficile es la principal causa de diarrea infecciosa adquirida en el hospital; su creciente incidencia, las menores tasas de respuesta al tratamiento inicial y la mayor tasa de recaídas han incrementado la carga de la enfermedad. Objetivo. Determinar las características clínicas de los pacientes hospitalizados con enfermedad asociada a C. difficile. Materiales y métodos. Se hizo un estudio de casos anidado en una cohorte. Se revisaron las historias clínicas de pacientes con diarrea iniciada durante su hospitalización a quienes se les había practicado la prueba de detección de la toxina A-B de C. difficile, entre febrero de 2010 y febrero de 2012. Se definió como caso al paciente hospitalizado con diarrea y prueba de Enzyme Linked Fluorescent Assay (ELFA) positiva para la toxina y, como control, a aquel con resultado negativo para la toxina. Se recolectaron los datos demográficos y clínicos, así como la información sobre los factores asociados, la estancia hospitalaria, el tratamiento y las complicaciones. Perfil clínico y demográfico y factores de riesgo frente a la infección por Clostridium difficileResultados. Durante el periodo de seguimiento se recolectaron datos de 123 pacientes, de los cuales 30 fueron positivos para la toxina. La edad media en la población de estudio fue de 49 años y el 60 % correspondía a hombres. Los síntomas predominantes fueron el dolor abdominal (35 %) y la fiebre (34 %). Las principales complicaciones fueron la alteración electrolítica y la sepsis grave asociada con disfunción renal. La mortalidad total fue de 13 % y los factores independientes asociados con la aparición de la infección fueron el uso de inhibidores de la bomba de protones y la cirugía gastrointestinal previa. Conclusiones. El uso de inhibidores de la bomba de protonesy la cirugía gastrointestinal previa fueron factores asociados con la infección por C. difficile. Clinical and demographic profile and risk factors for Clostridium difficile infectionIntroduction: Clostridium difficile infection is the leading cause of nosocomial infectious diarrhea. The increasing incidence added to a lower rate of response to the initial treatment and higher rates of relapse has generated a higher burden of the disease. Objective: To determine the clinical characteristics of hospitalized patients with C. difficile infection. Materials and methods:We made a nested case-cohort study. We reviewed medical records of the patients with nosocomial diarrhea for whom an assay for toxin A-B of C. difficile had been requested from February, 2010, to February, 2012. We defined case as a patient with diarrhea and a positive assay for the toxin, and control as those patients with a negative assay for the toxin. We collected data on demographic and clinical characteristics, risk factors, hospital length of stay, treatment, and complications. Results: We collec...

show abstract

Factors associated with prolonged symptoms and severe disease due to Clostridium difficile

Abstract: risk factors for severity of CDAD include functional disability, cognitive impairment, and recent endoscopy. Anticipation of severe CDAD may limit morbidity and mortality.

Cited by 129 publications

References 30 publications

Severity of Clostridium difficile–Associated Disease (CDAD) in Allogeneic Stem Cell Transplant Recipients: Evaluation of a CDAD Severity Grading System

Severity of Clostridium difficile–Associated Disease (CDAD) in Allogeneic Stem Cell Transplant Recipients: Evaluation of a CDAD Severity Grading System

Alternative treatments for Clostridium difficile disease: what really works?

Clinical and demographic profile and risk factors for Clostridium difficile infection

Contact Info

Product

Resources

About