Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study

Motoc, Nicoleta Ştefania; Ruta, Victoria-Maria; Milena, Man; Ungur, Rodica; Ciortea, Viorela Mihaela; Irsay, László; Nicola, Andrea; Vălean, Dan; Usatiuc, Lia; Matei, Ileana Rodica; Borda, Ileana Monica

doi:10.3390/medicina58060707

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…Low levels of iron have been reported in Romanian patients early on, accordingly to international data [ 56 , 72 , 88 ]; however, there have been cases of normal values reported [ 54 , 86 , 89 , 90 ], while others have reported high levels of FER, including in children [ 14 , 21 , 23 , 24 , 25 , 26 , 29 , 30 , 31 , 35 , 36 , 41 , 43 , 48 , 62 , 74 , 79 ], with a few rare cases of vertical transmission describing increased FER levels, as observed in Iacob et al’s study [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

“…The number of days with a traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) days in patients with moderate COVID-19. Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR tests from the nasal swab (therefore prolonged viral load) [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…Its half-life is approximately 19 h and its concentration diminishes as the patient heals and the inflammatory stages pass [ 18 , 19 ]. This particular protein was studied extensively during the COVID-19 pandemic, as it is one of the earliest markers to show elevation since the beginning [ 14 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

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COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Musat,

Sorop,

Sorop

et al. 2023

Life

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COVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered the golden standard, while antibodies are still useful for monitoring both patients and their vaccination status. In our country, biomarkers such as CRP, LDH, transaminases, cardiac, and iron markers have been used to assess the status of patients and even predict illness outcome. CRP, IL-6, LDH, FER, fibrinogen, creatinine, and vitamin D levels have been associated with increased severity, risk of ICU admission, and death. Cardiac markers and D-dimers are also good predictors, but their role seems more important in patients with complications. HDL cholesterol and BUN levels were also suggested as potential biomarkers. Hematological issues in SARS-CoV-2 infections include neutrophilia, lymphopenia and their ratio, while PCT, which is a marker of bacterial infections, is better to be used in patients with co- or supra-infections. The current research is a narrative review that focuses on the laboratory results of Romanian COVID-19 patients. The goal of this article is to provide an update on the research on biomarkers and other laboratory tests conducted inside the borders of Romania and identify gaps in this regard. Secondly, options for further research are discussed and encouraged.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Musat,

Sorop,

Sorop

et al. 2023

Life

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“…Patients with a laboratory-confirmed (PCR test) diagnosis of COVID-19 were included in the study. Mild COVID-19 patients were considered as patients with mild symptoms without pneumonia, moderate as patients with non-severe pneumonia, and severe as patients who needed hospitalisation in the ICU [ 13 ]. Contraindications to participate in the study were: aneurysms, uncontrolled hypertension, and urinary incontinence [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Assessment of the Function of Respiratory Muscles in Patients after COVID-19 Infection and Respiratory Rehabilitation

et al. 2023

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Objectives: The MIP (maximum inspiratory pressure) and MEP (maximum expiratory pressure) are sensitive indicators of respiratory muscle function. The aim of the study was to assess the function of respiratory muscles in patients after COVID-19 infection, before and after hospitalisation at the Pulmonary Rehabilitation Ward. Materials and Methods: The study was conducted on a group of 19 people with laboratory-confirmed COVID-19 infection, who, in the period from 1 February to 31 May 2021, were hospitalised at the Independent Public Pulmonary Hospital and underwent respiratory rehabilitation in hospital conditions. A statistical analysis was performed using the STATISTICA package, ver. 10. A respiratory pressure meter (RP Check) was used to measure muscle strength. Measurements were performed twice on each patient—before admission and after hospitalisation in the Pulmonary Rehabilitation Ward. Results: We show that conducting pulmonary rehabilitation contributes to the increase in MIP and MEP, which are associated with increased strength of the inspiratory and expiratory muscles. The average value of MIP increased by 11.95 cmH2O and MEP by 26.16 cmH2O. The improvement was visible in both female and male patients. Conclusions: Pulmonary rehabilitation contributes to the improvement of respiratory muscle function indicators among patients after COVID-19 infection. Assessment of the MIP and MEP indices is a simple and quick way to reliably assess the function of the respiratory muscles.

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“…In the literature, a few studies have focused on the issue of time-to-negative swab; nonetheless, some data on the positivity time span were possible to deduce from studies with different endpoints: this time ranged from 17 to 32 days in patients under 18 years old [ 4 , 5 ], and from 14 to 27 days in adult patients [ 6 – 8 ]. Moreover, according to the recent studies conducted in the Omicron era, a prolonged time-to-negative swab, indicator of prolonged viral shedding, may be an element considered able to increase the risk of developing viral mutations [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding: the results from the CoviCamp cohort

Grimaldi,

Russo,

Pisaturo

et al. 2023

Infection

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Introduction The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab. Methods We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available. Results 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group. Discussion Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition.

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Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study

Cited by 5 publications

References 29 publications

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Assessment of the Function of Respiratory Muscles in Patients after COVID-19 Infection and Respiratory Rehabilitation

Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding: the results from the CoviCamp cohort

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