Factors associated with prior acute pancreatitis episodes among patients with chronic pancreatitis

Ru, Nan; Zhu, Jiahui; Hu, Liang‐Hao; Wu, Shaofang; Xu, Xiaoyue; Wang, Lei; Yu, Feifei; Yan, Zijun; Guo, Jian-You; Li, Zhao‐Shen; Zou, Wenbin; Liao, Zhuan

doi:10.1016/j.dld.2021.03.001

Cited by 5 publications

(3 citation statements)

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“…To further explore the impact of pancreatic necrosis on progression rate, we have performed additional regression analyses for disease severity and complications within the subgroup of patients with predicted severe pancreatitis, which failed to detect any relevant statistically differences (data not shown). For CP, other independent risk factors than those previously mentioned, were male sex, smoking, and RAP, which is in line with previous studies 3,25 . In the majority of patients, CP was preceded by RAP (63%).…”

Section: Discussionsupporting

confidence: 91%

“…24 On the contrary, we found a lower incidence of CP, which can be explained by a smaller proportion of alcoholic pancreatitis patients included in the current study. 25 Furthermore, our incidence rate of pancreatic cancer was comparable to the previous study 4 but significantly higher compared to the 0.2% incidence rate of the Dutch general population between 2008 and…”

Section: Discussionsupporting

confidence: 86%

“…For CP, other independent risk factors than those previously mentioned, were male sex, smoking, and RAP, which is in line with previous studies. 3,25 In the majority of patients, CP was preceded by RAP (63%). Post hoc risk analyses for the impact of lifestyle modifications showed that alcohol cessation significantly reduced the risk of RAP in patients with alcoholic pancreatitis, which was not the case for CP.…”

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confidence: 99%

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Development of pancreatic diseases during long‐term follow‐up after acute pancreatitis: a post‐hoc analysis of a prospective multicenter cohort

de Rijk,

Sissingh,

Boel

et al. 2024

J of Gastro and Hepatol

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Background and AimMore insight into the incidence of and factors associated with progression following a first episode of acute pancreatitis (AP) would offer opportunities for improvements in disease management and patient counseling.MethodsA long‐term post hoc analysis of a prospective cohort of patients with AP (2008–2015) was performed. Primary endpoints were recurrent acute pancreatitis (RAP), chronic pancreatitis (CP), and pancreatic cancer. Cumulative incidence calculations and risk analyses were performed.ResultsOverall, 1184 patients with a median follow‐up of 9 years (IQR: 7–11) were included. RAP and CP occurred in 301 patients (25%) and 72 patients (6%), with the highest incidences observed for alcoholic pancreatitis (40% and 22%). Pancreatic cancer was diagnosed in 14 patients (1%). Predictive factors for RAP were alcoholic and idiopathic pancreatitis (OR 2.70, 95% CI 1.51–4.82 and OR 2.06, 95% CI 1.40–3.02), and no pancreatic interventions (OR 1.82, 95% CI 1.10–3.01). Non‐biliary etiology (alcohol: OR 5.24, 95% CI 1.94–14.16, idiopathic: OR 4.57, 95% CI 2.05–10.16, and other: OR 2.97, 95% CI 1.11–7.94), RAP (OR 4.93, 95% CI 2.84–8.58), prior pancreatic interventions (OR 3.10, 95% CI 1.20–8.02), smoking (OR 2.33, 95% CI 1.14–4.78), and male sex (OR 2.06, 95% CI 1.05–4.05) were independently associated with CP.ConclusionDisease progression was observed in a quarter of pancreatitis patients. We identified several risk factors that may be helpful to devise personalized strategies with the intention to reduce the impact of disease progression in patients with AP.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

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confidence: 99%

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