Factors associated with ownership of insecticide-treated nets for malaria prevention among pregnant women in Ghana

Duut, Timothy; Alhassan, Abdul Rauf

doi:10.18332/pht/152624

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…These interventions have shown a considerable reduction in morbidity and mortality due to malaria in children and pregnant women. Furthermore, these interventions were associated with a decrease in maternal parasitaemia and a reduction in maternal anaemia [24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…This study involved consecutively 156 pregnant women consulting the BDH. The age of the participants ranged from 14 to 48 years old, with a mean age of 27.41 years (Standard Deviation ± 6.67), and a median age of 28 years (IQR: [23][24][25][26][27][28][29][30][31][32]. The majority of participants, were under 30 years old (64.10%), were single (40.38%), were self-employed (76.92%), had a secondary level (82.05%), were in the second trimester of pregnancy (41.03%) and 76.28% had a secondary sector of activity.…”

Section: Characteristics Of Study Populationmentioning

confidence: 99%

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Plasmodium falciparum Infection and Associated Risk Factors in Pregnant Woman Attending Bafang District Hospital, Semi-Rural Area, West Region of Cameroon: A Cross-Sectional Study

Ngounouh

Kengne²,

Likeng³

et al. 2022

IJTDH

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Background: Malaria is a major public health problem in countries with limited resources. This morbid and fatal infection mainly affects vulnerable groups with weak immunity, such as children and pregnant women. In pregnant women, malaria leads to the occurrence of anaemia with the consequences of abortion, low birth weight (LBW) of the child and death of the baby. This study aimed to determine the Plasmodium falciparum (P. falciparum) infection and associated risk factors among pregnant women attending the Bafang district hospital (BDH). Methods: A hospital based quantitative cross-sectional and descriptive study were conducted from May 30th, to June 24th, 2022 among 156 pregnant women attending the BDH, West Region of Cameroon. All pregnant women consented to participate in the study without any constraint. Blood samples were collected, thick film and stained blood smear examined for Plasmodium trophozoites and gametocytes respectively. Statistical analyses were performed using Epi Info v. 7 software with any p-value<0.05 considered statistically significant. Results: The age of the study participants ranged from 14 to 48 years old (mean age of 27.41 ± 6.67 years). Of the 156 pregnant women tested, 25% (95% CI: 18.42%-32.55%) were infected with P. falciparum, infection was high in pregnant women aged < 30 years old (66.67%), in non-salaried (82.05%), in pregnant women in the second trimester of pregnancy (48.72%) with no difference statistically significant (p-value<0.05). Furthermore, the use of mosquito nets (OR= 3.88, 95% CI: 1.78-8.43, p-value=0.0003), taking intermittent preventive treatment (IPT) (OR= 2, 95, 95% CI: 1.31-6.59, p-value=0.006) and the number of IPT doses (p-value=0.0006) were risk factors statistically associated with P. falciparum infection. Conclusion: This study revealed a high prevalence of P. falciparum among pregnant women attending BDH. The use of mosquito nets, the taking of IPT were the factors statistically associated with the infection.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Study Populationmentioning

confidence: 99%

Plasmodium falciparum Infection and Associated Risk Factors in Pregnant Woman Attending Bafang District Hospital, Semi-Rural Area, West Region of Cameroon: A Cross-Sectional Study

Ngounouh

Kengne²,

Likeng³

et al. 2022

IJTDH

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“…The importance of wearing long sleeves can also be understood in the context of malaria prevention in high-transmission areas. People living in these areas are often exposed to the risk of mosquito bites daily, and the use of clothing that protects the body, including long sleeves, can be a simple but effective step in reducing the risk of disease transmission (Duut & Alhassan, 2022). In addition to providing direct protection against mosquito bites, the use of long sleeves also contributes to a holistic approach to prevention.…”

Section: Figure 1 Data On Positive Cases Of Malaria In 2022 Based On ...mentioning

confidence: 99%

Investigating Malaria Susceptibility in Central Maluku District: A Focus on Anopheles Mosquito Habitats

Firmansyah,

Parulian,

Kristiawan

et al. 2024

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Malaria remains a formidable challenge to global public health, with an estimated 241 million cases reported across 85 endemic countries in 2020. Within this context, Indonesia, and particularly the Central Maluku Regency, has reported a notable burden of the disease, evidenced by 102 confirmed cases in 2022 as per the annual parasite incidence (API) data, highlighting indigenous transmissions in specific locales. This research was conducted to assess the susceptibility to malaria within the operational area of the Hila Perawatan Primary Healthcare Centre (Puskesmas), situated in the Leihitu sub-district of Ambon Island, through an examination of Anopheles mosquito breeding sites, larval densities, and habitat indices. Employing a descriptive research design, this cross-sectional observational study was carried out on October 26-27, 2023, to meticulously document the ecological footprint of the Anopheles mosquito, particularly Anopheles farauti. Findings reveal a habitat index (HI) of 33% in Kaitetu village with a larval density of 20%, indicating a significant presence of Anopheles farauti larvae. These findings suggest that environmental and behavioral factors within households, such as the use of gauze and ceilings, nocturnal activities, application of mosquito repellents, wearing of long-sleeved clothing, and utilization of mosquito nets, are pivotal in influencing malaria transmission dynamics. This study underscores the imperative of integrating environmental management with community engagement strategies to mitigate malaria transmission in endemic regions. The results not only provide a nuanced understanding of the Anopheles mosquito's breeding patterns and its implications for malaria transmission but also offer a foundational basis for tailoring targeted interventions aimed at reducing the malaria burden in the Central Maluku District.

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“…Plasmodium falciparum parasites have been reported to cause the most severe malaria, with the sub-Saharan Africa having the highest morbidity and mortality (Siagian, 2022). Malaria poses major health risk, huge economic and social burden on endemic countries (Duut & Alhassan, 2022). Even though pregnant women and children under the age of ve are more vulnerable to malaria, the disease poses a greater risk to everybody (Duut &Alhassan, 2022 andAlhassan, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Malaria poses major health risk, huge economic and social burden on endemic countries (Duut & Alhassan, 2022). Even though pregnant women and children under the age of ve are more vulnerable to malaria, the disease poses a greater risk to everybody (Duut &Alhassan, 2022 andAlhassan, 2021). The United Nations' Agenda for Sustainable Development Goal 3, which included total malaria eradication by 2030, may not be met due to drug resistance (DESA, 2022).…”

Section: Introductionmentioning

confidence: 99%

Stage -Specific Antimalarial Activity of Alkaloidal Fractions of the Avicennia africana P. Beauv. (Avicenniaceae) Leaf Extract

Ahmed,

Ackah-Armah,

Ghartey-Kwansah

et al. 2024

Preprint

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Background The global call for malaria eradication rested on finding drugs that not only act against asexual but also sexual forms of the parasite. The drawbacks in disease control and prevention due to drug-resistant clones of the parasite piqued our interest in exploring for alternative antimalarial drugs from the mangrove resources. Aims This study evaluates the stage-specific anti-malarial and cytotoxic activities of the fractions of crude alkaloidal extracts from Avicennia africana leaves. Methods The crude and alkaloidal extracts (AAA and AAQ) from A. africana were fractionated using column chromatography and further analysed using GC-mass spectroscopy. The fractions were then tested for antimalarial activity against the trophozoites, schizonts, and gametocyte stages of chloroquine-sensitive strains of 3D7 P. falciparum using the SYBR Green 1 assay. The cytotoxic effects of the fractions were evaluated using the MTT-based assay. Results The fractions AAA1-AAA5 and AAQ1-AAQ5 produced promising trophozoitocidal activities with an IC50 value range of 0.399–45.690 µg/mL, with the artesunate (ref drug) yielding 0.09x103 µg/mL. The schizonticidal and gametocytocidal activities of selected fractions demonstrated high potency with IC50s of 0.622–18.820 µg/mL against artesunate (ref drugs) with 1.800x10-3 and 5.100x10-3 µg/mL, respectively. The cytotoxic effect of fractions produced CC50 that was higher than 100 µg/mL with negligible cytotoxicity on erythrocytes and SI that ranged from 2.189 to 280.899. The major compounds identified in fractions AAA1, AAQ1, and AAQ2 were 8-carbomoylquinoline, razoxane, and dexrazoxane, respectively. Conclusion The fractions exhibited promising trophozoitocidal, schizonticidal, and gametocytocidal effects with no significant cytotoxic effects on RBCs. Quinoline-based alkaloids and iron chelators in this plant are implicated as possible lead-compound transmission blockers of the parasite.

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Factors associated with ownership of insecticide-treated nets for malaria prevention among pregnant women in Ghana

Cited by 8 publications

References 18 publications

Plasmodium falciparum Infection and Associated Risk Factors in Pregnant Woman Attending Bafang District Hospital, Semi-Rural Area, West Region of Cameroon: A Cross-Sectional Study

Plasmodium falciparum Infection and Associated Risk Factors in Pregnant Woman Attending Bafang District Hospital, Semi-Rural Area, West Region of Cameroon: A Cross-Sectional Study

Investigating Malaria Susceptibility in Central Maluku District: A Focus on Anopheles Mosquito Habitats

Stage -Specific Antimalarial Activity of Alkaloidal Fractions of the Avicennia africana P. Beauv. (Avicenniaceae) Leaf Extract

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