Factors Associated with Overall and Attributable Mortality in Invasive Aspergillosis

Nivoix, Yasmine; Velten, Michel; Letscher-Bru, Valérie; Moghaddam, Alireza; Natarajan-Amé, Shanti; Fohrer, Cécile; Lioure, Bruno; Bilger, Karin; Lutun, P.; Marcellin, Luc; Launoy, A.; Freys, G.; Bergerat, Jean‐Pierre; Herbrecht, Raoul

doi:10.1086/592255

Cited by 310 publications

(290 citation statements)

References 28 publications

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“…2,3 Since past studies frequently focused on groups of patients with marked diversity in risk, disease, disease stage, and type of transplant they were unable to provide clear conclusions about the impact of individual risk factors on outcome. [12][13] To avoid such confounding factors, the present analysis focused only on patients with AML who received standard chemotherapy and who had proven/probable invasive aspergillosis.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining 12 patients received only targeted therapy (9%). The mean period between symptom onset and the start of empirical/preemptive treatment was 6 days (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The difference between times to treatment was not significant (symptoms to empirical therapy, 1-18 days, mean 5 days; symptoms to pre-emptive therapy 1-19 days, mean 6 days).…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study

Pagano¹,

Caira²,

Candoni³

et al. 2009

Haematologica

286

212

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Section: Discussionmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study

Pagano¹,

Caira²,

Candoni³

et al. 2009

Haematologica

286

212

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“…In high risk neutropenic patients, the mortality rate related with systemic candidiasis has been reported to be 50% and to invasive aspergillosis as high as 80-100% (20). The most important factor which has been shown to affect survival is neutropenia in invasive fungal infections (21,22). The most important reason for lack of improvement of neutropenia is absence of response of accompanying malignancy to treatment.…”

Section: Candida Albicansmentioning

confidence: 99%

Febrile neutropenia in children with acute lymphoblastic leukemia: single center experience

et al. 2016

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Aim: An important life-threatening complication of intensive chemotherapy administered in children with leukemia is febrile neutropenia. The objective of this study was to evaluate the clinical features and consequences of febrile neutropenia attacks in children who were treated for acute lymphoblastic leukemia. Material and Methods:Nighty-six children who received chemotherapy for acute lymphoblastic leukemia in our center between January 1995 and December 2010 were included in the study. The data related to demographic characteristics, treatment features, relapse and febrile neutropenia incidences, risk factors, culture results and prognosis were retrospectively evaluated from the patients' files.Results: A total of two hundred-ninety nine febrile neutropenia attacks observed in the patients during initial treatment and relapse treatment were evaluated. When the incidence of febrile neutropenia was evaluated by years, it was observed that the patients treated after year 2000 had statistically significantly more febrile neutopenia attacks compared to the patients treated before year 2000. When the incidences of febrile neutropenia during initial treatment and during relapse treatment were compared, it was observed that more febrile neutropenia attacks occured during relapse treatment. Fifty-nine percent of all febrile neutropenia attacks were fever of unknown origin. Eighty microorganisms grew in cultures during febrile neutropenia throughout treatment in 75 patients; 86% were bacterial infections (50% gram positive and 50% gram negative), 8% were viral infections and 6% were fungal infections. Coagulase negative staphylococcus (n=17) was the most frequent gram positive pathogen; E. Coli (n=17) was the most commonly grown gram negative pathogen. Conclusions:In this study, it was found that an increase in the incidence of febrile neutropenia occured in years. Increments in treatment intensities increase the incidence of febrile neutropenia while improving survival. Evaluation of febrile neutropenia results by hematology-oncology units in years will be directive in early and successful treatment. (Turk Pediatri Ars 2016; 51: 79-86)

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“…The more serious form of the disease is invasive pulmonary aspergillosis, which is most common in individuals with defective immune systems; users of immunosuppressive therapies, such as those used to prevent rejection following organ transplantation; and individuals at latestage human immunodeficiency virus infection. Survival rates in humans are ;50% (Nivoix et al 2008).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

Durrant¹,

Tayem²,

Yalcin³

et al. 2011

Genome Res.

144

193

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The Collaborative Cross (CC) is a genetic reference panel of recombinant inbred lines of mice, designed for the dissection of complex traits and gene networks. Each line is independently descended from eight genetically diverse founder strains such that the genomes of the CC lines, once fully inbred, are fine-grained homozygous mosaics of the founder haplotypes. We present an analysis of 120 CC lines, from a cohort of the CC bred at Tel Aviv University in collaboration with the University of Oxford, which at the time of this study were between the sixth and 12th generations of inbreeding and substantially homozygous at 170,000 SNPs. We show how CC genomes decompose into mosaics, and we identify loci that carry a deficiency or excess of a founder, many being deficient for the wild-derived strains WSB/EiJ and PWK/PhJ. We phenotyped 371 mice from 66 CC lines for a susceptibility to Aspergillus fumigatus infection. The survival time after infection varied significantly between CC lines. Quantitative trait locus (QTL) mapping identified genome-wide significant QTLs on chromosomes 2, 3, 8, 10 (two QTLs), 15, and 18. Simulations show that QTL mapping resolution (the median distance between the QTL peak and true location) varied between 0.47 and 1.18 Mb. Most of the QTLs involved contrasts between wild-derived founder strains and therefore would not segregate between classical inbred strains. Use of variation data from the genomes of the CC founder strains refined these QTLs further and suggested several candidate genes. These results support the use of the CC for dissecting complex traits.

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Factors Associated with Overall and Attributable Mortality in Invasive Aspergillosis

Cited by 310 publications

References 28 publications

Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study

Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study

Febrile neutropenia in children with acute lymphoblastic leukemia: single center experience

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

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