Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

Lee, Kwanghyun; Park, Chan Keum; Kim, Eun Woo; Kim, Joo Yeon; Yang, Hyun-Jin; Choi, Wungrak; Seong, Gong Je; Kim, Chan Yun; Bae, Hyoung Won

doi:10.1007/s10384-020-00757-w

Cited by 3 publications

(4 citation statements)

References 34 publications

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“…8 Lee et al hypothesized that mGCIPL progression could be detected earlier due to age-related deterioration of retinal microcirculation because aging was associated with decreased macular vascular density. 8,21 In our study, the mean age in the mGCIPL-first progression group was greater than that in the pRNFL-first progression group, although the difference was not statistically significant in the multivariate analysis. These disparate findings could be explained by the varying ages of the study participants.…”

Section: Discussioncontrasting

confidence: 58%

Optic Nerve Head Morphology is Associated with the Initial Location of Structural Progression in Early Open Angle Glaucoma

Park,

Bae

et al. 2023

Journal of Glaucoma

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Purpose: To investigate the effects of clinical variables on the temporal relationship between macular ganglion cell-inner plexiform layer (mGCIPL) loss and peripapillary retinal nerve fiber layer (pRNFL) loss in glaucoma. Precis: Glaucoma eyes with a small cup-to-disc ratio tend to show retinal nerve fiber layer progression earlier than ganglion cell-inner plexiform layer progression. Methods: This retrospective observational study used medical records of patients diagnosed with open-angle glaucoma. Structural change was determined using guided progression analysis software of Cirrus optical coherence tomography. Based on the time of detection of pRNFL and mGCIPL changes, eyes showing progressive layer loss were categorized into the pRNFL-first and mGCIPL-first groups. The association between sites of layer thinning and clinical variables such as major retinal arterial angles and several optic disc measurements including disc area, average cup-to-disc ratio (CDR), and vertical CDR were analyzed. Results: A total of 282 eyes were included in the study, of which 104 showed structural progression either in the mGCIPL or pRNFL. Out of these, 49 eyes showed first progression in pRNFL, while 37 eyes showed first progression in mGCIPL. The minimum mGCIPL thickness, pRNFL thickness, average CDR, vertical CDR, and location of progression were significantly different between the two groups (P=0.041, P=0.034, P=0.015, P<0.001, and P<0.001, respectively). In multivariate analysis, average CDR and vertical CDR were significantly associated with the progression site (P=0.033 and P=0.006, respectively). The structural changes in the inferoinferior area and the superior vulnerability zone were significantly associated with RNFL-first progression (P<0.001 for both). Conclusion: The location of layer loss and CDR are related to the layer where loss is first detected (either pRNFL or mGCIPL) in open-angle glaucoma.

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Section: Discussioncontrasting

confidence: 58%

Optic Nerve Head Morphology is Associated with the Initial Location of Structural Progression in Early Open Angle Glaucoma

Park,

Bae

et al. 2023

Journal of Glaucoma

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“…The diagnostic ability of circumpapillary vessel density (cpVD) and macular vessel density (mVD) in glaucoma patients of different glaucoma severity have been reported using several OCTA instruments 10 – 19 . In addition, OCTA has been shown to be able to detect focal glaucomatous changes 20 , which is key to diagnosing early glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic ability and sectoral structure–function relationship of circumpapillary and macular superficial vessel density in early glaucomatous eyes

Akiyama

Saito

Shirato³

et al. 2022

Sci Rep

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This study aimed to evaluate the diagnostic ability and sectoral structure function relationship of circumpapillary vessel density (cpVD) and macular vessel density (mVD) with optical coherence tomography angiography (OCTA) in early glaucomatous (EG) eyes. 224 EG eyes of 167 patients (mean deviation (MD) > − 6 dB) and 70 normal eyes of 70 subjects were enrolled in this retrospective cross-sectional study. All patients underwent OCT and OCTA scanning. Diagnostic abilities were evaluated with area under receiver operating characteristic curves (AUROC). Structure function relationships of superior, inferior and Garway-Heath sectoral values with its corresponding visual field (VF) sensitivity were determined using linear mixed models. AUROCs were 0.798, 0.621, 0.876 and 0.835 for cpVD, mVD, circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and ganglion cell-inner plexiform layer, respectively. AUROC of cpVD was significantly lower than cpRNFLT (P = 0.010) and higher than mVD (P < 0.001). All Garway-Heath sectors of cpVD significantly correlated with its corresponding VF sensitivity except for the nasal sector. MVD also showed significant structure function relationship and the correlations were stronger in the perifoveal region (6 mm annulus) than in the parafoveal region (3 mm annulus). CpVD demonstrated moderate diagnostic ability and both cpVD and mVD demonstrated significant association with VF sensitivity in EG eyes.

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“…Increased retinal perfusion could be the reason of this improvement since retinal circulation has been reported to have an important role in influencing contrast sensitivity [ 33 ]. Meanwhile, KRG has been reported to increase ocular blood flow [ 10 ], and ginseng extract has been found to protect against diabetes-induced retinal microvascular damage [ 34 ]. It is also known that as glaucoma progresses, microvascular damage occurs, resulting in reduced perfusion [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another possible explanation for the improved contrast sensitivity is that ginseng could improve the function of retinal ganglion cells. Red ginseng has been reported to increase of the amplitude of electroretinography b wave peak, suggesting that red ginseng extract may modulate the retinal neural network, including Muller cells and bipolar cells [ 34 ]. Likewise, KRG may enhance the function of the inner retina, including retinal ganglion cells, and elicit improvement in contrast sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Effect of red ginseng on visual function and vision-related quality of life in patients with glaucoma

Lee

Yang²,

Kim

et al. 2021

Journal of Ginseng Research

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Background Red ginseng has been found to improve ocular perfusion and dry eye syndrome in glaucomatous eyes; however, its effects on visual function and vision-related quality of life have not been investigated. This study sought to evaluate the effects of red ginseng on visual function and vision-related quality of life in glaucoma patients using contrast sensitivity and a questionnaire. Methods Participants were randomly assigned to two groups in this prospective, randomized, double-blind study: in one group, red ginseng was taken first, followed by a placebo, and in the other, placebo was taken first, followed by red ginseng. We measured and compared changes in contrast sensitivity and vision-related quality of life between the two groups. Contrast sensitivity was measured using OPTEC® 6500P, and vision-related quality of life was evaluated using the 25-item National Eye Institute Visual Function Questionnaire. One-way and two-way repeated measure analyses of variance were used for the comparison. Relationships between respective changes in dry eye syndrome and contrast sensitivity were also analyzed. Results Daytime contrast sensitivity and ocular pain improved after the administration of red ginseng. Nighttime contrast sensitivity was improved in early or moderate glaucoma. Improved contrast sensitivity was not associated with improvement in dry eye syndrome. Conclusion Red ginseng could improve contrast sensitivity and ocular pain in patients with glaucoma. The mechanism underlying improvement in contrast sensitivity appears to be associated with enhanced retinal perfusion or retinal ganglion cell function, but not dry eye syndrome.

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Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

Cited by 3 publications

References 34 publications

Optic Nerve Head Morphology is Associated with the Initial Location of Structural Progression in Early Open Angle Glaucoma

Optic Nerve Head Morphology is Associated with the Initial Location of Structural Progression in Early Open Angle Glaucoma

Diagnostic ability and sectoral structure–function relationship of circumpapillary and macular superficial vessel density in early glaucomatous eyes

Effect of red ginseng on visual function and vision-related quality of life in patients with glaucoma

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