Factors Associated With Lung Function Decline in Adult Patients With Stable Non-Cystic Fibrosis Bronchiectasis

Martínez‐García, Miguel Ángel; Soler-Cataluña, Juan José; Perpiñá-Tordera, Miguel; Román-Sánchez, Pilar; Soriano, Joan B.

doi:10.1378/chest.07-0490

Cited by 435 publications

(335 citation statements)

References 36 publications

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“…Spirometry revealed no significant decrease in lung function in our study population. These findings differ from previous observations in symptomatic bronchiectasis, which often included mild airway obstruction (Pasteur et al 2000;King et al 2006aKing et al , 2006bMartinez-Garcia et al 2007). We speculate that the difference might be resulted from the difference in the study designs and studied populations.…”

Section: Respiratory Symptoms % (N)contrasting

confidence: 99%

High Prevalence of Bronchiectasis in Adults: Analysis of CT Findings in a Health Screening Program

Kwak

Moon

Choi

et al. 2010

Tohoku J. Exp. Med.

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Bronchiectasis is one of the common chronic respiratory diseases and associated with respiratory morbidity and mortality. However, neither its prevalence nor its etiology is well-defined. We aimed to estimate the prevalence and risk factors of bronchiectasis in adults. In a retrospective study, we analyzed radiologic findings on chest computed tomography (CT) images performed as part of a health-screening program. From January to December 2008, 1,409 (24.6%) of 5,727 participants in the screening program of a health promotion center at a university hospital underwent chest CT scans based on the subject' s decision. Bronchiectasis was diagnosed, if there was abnormal bronchial dilatation in any area of both lungs on chest CT. Respiratory symptoms, smoking status, and past medical history were also analyzed to define clinical characteristics and risk factors of bronchiectasis. Of 1,409 patients (aged 23-86 years), who were screened for respiratory diseases using chest CT for one year in a health promotion center, 129 patients (9.1%) were diagnosed with bronchiectasis. The prevalence of bronchiectasis was higher in females than in males (11.5% vs. 7.9%, p = 0.022) and increased with age. Respiratory symptoms were reported in 53.7% of subjects. Previous history of tuberculosis (TB) (OR 4.61, 95% CI 2.39-8.88, p = 0.001) and age (OR 2.49, 95% CI 1.56-3.98, p = 0.001) were significantly associated with bronchiectasis. This retrospective analysis of chest CT findings in health screening examinees revealed a very high prevalence of bronchiectasis in adults. Previous TB infection is one of the major causes of bronchiectasis.

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Section: Respiratory Symptoms % (N)contrasting

confidence: 99%

High Prevalence of Bronchiectasis in Adults: Analysis of CT Findings in a Health Screening Program

Kwak

Moon

Choi

et al. 2010

Tohoku J. Exp. Med.

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“…Neither the presence of chronic colonisation by multiresistant Gramnegative bacilli nor the isolation of Staphylococcus aureus, atypical mycobacteria and fungi, presented any significant independent predictive power for mortality. Therefore, it was finally decided to include only chronic colonisation by P. aeruginosa in the score, as this is the only microorganism that has been related in the current literature with an increase in mortality and a poorer functional evolution in patients with non-CF bronchiectasis [5,29,30].…”

Section: Discussionmentioning

confidence: 99%

“…Bronchiectasis is associated with chronic and frequently purulent expectoration, multiple exacerbations and progressive, potentially disabling dyspnoea. These events gradually worsen the health-related quality of life and lung function of affected patients [4][5][6]. In recent years, bronchiectasis has become a major health concern for several reasons: a significant increase in the number of diagnoses [7,8], the increase in the mortality rate [9] and in hospital admissions [10], the considerable health costs involved (US$7827 per hospitalisation) [10], its negative impact on the quality of life [6] and pulmonary function of patients (annual loss of nearly 50 mL of forced expiratory volume in 1 s (FEV1)) [5] and its deleterious effects on underlying diseases [11].…”

Section: Introductionmentioning

confidence: 99%

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

et al. 2013

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Bronchiectasis is a multidimensional disease and, therefore, its severity or prognosis cannot be adequately quantified by analysing one single variable. The objective of the present study was to develop a multidimensional score that classifies the severity of bronchiectasis according to its prognosis. This is an observational multicentre study including 819 patients diagnosed with non-cystic fibrosis bronchiectasis using high-resolution computed tomography. 397 subjects were selected at random to construct the score while the remaining 422 were used for its validation. The outcome was 5-year all-cause mortality after radiological diagnosis. A logistic regression analysis was used to select the variables included in the final score.The final seven-point score incorporated five dichotomised variables: forced expiratory volume in 1 s % predicted (F, cut-off 50%, maximum value 2 points); age (A, cut-off 70 years, maximum value 2 points); presence of chronic colonisation by Pseudomonas aeruginosa (C, dichotomic, maximum value 1 point); radiological extension (E, number of lobes affected, cut-off two lobes, maximum value 1 point); and dyspnoea (D, cut-off grade II on the Medical Research Council scale, maximum value 1 point) to construct the FACED score. The validation cohort confirmed the score's validity.We conclude that this easy-to-use multidimensional grading system proved capable of accurately classifying the severity of bronchiectasis according to its prognosis. @ERSpublications An easy-to-use multidimensional grading system accurately classifies bronchiectasis severity according to prognosis

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“…17,18 Among the studies assessing pulmonary function in adults with bronchiectasis, many included a significant proportion of smokers, and some have not excluded the results of patients with a lung resection from the analysis. 2 Although many studies sought to assess the factors associated with the deterioration of pulmonary function in individuals with bronchiectasis, [19][20][21][22][23] none measured the isolated effect of its different causes. Therefore, the aim of the present study was to assess the impact of the various causes of bronchiectasis on clinical features, pulmonary function tests, and HRCT.…”

mentioning

confidence: 99%

Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests

Lopes

Camilo

Menezes

et al. 2014

Clinical Medicine & Research

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Factors Associated With Lung Function Decline in Adult Patients With Stable Non-Cystic Fibrosis Bronchiectasis

Cited by 435 publications

References 36 publications

High Prevalence of Bronchiectasis in Adults: Analysis of CT Findings in a Health Screening Program

High Prevalence of Bronchiectasis in Adults: Analysis of CT Findings in a Health Screening Program

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests

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