Factors associated with increased noradrenaline levels in schizophrenic patients

Kemali, D.; Maj, Mario; Galderisi, Silvana; Ariano, M; Starace, Fabrizio

doi:10.1016/0278-5846(90)90063-m

Cited by 35 publications

(33 citation statements)

References 46 publications

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“…Further investigations using simultaneous measurements of locomotor activity and neurotransmitter release in presence of noradrenergic antagonists are required to support this hypothesis. In this respect, it is noteworthy that an overactivity of the NA system has been described in some schizophrenic patients and associated with the expression of positive symptoms (Lake et al 1980;van Kammen et al 1989;Kemali et al 1990;Yamamoto and Hornykiewicz 2004). Moreover, blockade of α1-noradrenergic receptors has been proposed to contribute to the therapeutic effects of atypical antipsychotics such as clozapine (Baldessarini et al 1992;Svensson 2000).…”

Section: Discussionmentioning

confidence: 96%

Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17

et al. 2007

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Section: Discussionmentioning

confidence: 96%

Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17

et al. 2007

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“…In particular, biochemical data indicate that a dysfunction of the N A system is as sociated with acute psychosis [1][2][3][4][5][6] or with paranoia [7,8] in schizophrenia. Most NA in the brain is ulti mately metabolized to 3-methoxy-4-hydroxyphenylglycol (M H PG).…”

Section: Introductionmentioning

confidence: 99%

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Kaneko

Honda²,

Kanno³

et al. 1992

Neuropsychobiology

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Plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) was measured in 19 patients with acute schizophrenia before and after neuroleptic therapy. Plasma antinoradrenergic activity (pANA) of the neuroleptics used was measured after treatment. Before treatment, pMHPG was higher in the patients than in 20 normal controls. There was a positive correlation between pMHPG level and the global severity of positive symptoms. After neuroleptic therapy, pMHPG was reduced, and there was a significant correlation between the decline in pMHPG and the improvement in positive symptom score. The decline in pMHPG was also correlated with pANA. These results suggest that there is a dysfunction of the noradrenergic system in the brains of some acute schizophrenics with mainly positive symptoms, and that this dysfunction may be improved, along with positive symptom score, after neuroleptic therapy.

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“…CSF levels of NA were reported to be unrelated to verbal abilities, arithmetic or memory function [74,75,77]. CSF MHPG levels were not associated with performance on tasks testing memory and executive function [29].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity

et al. 2005

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Background: Some clinical symptoms or cognitive functions have been related to the overall state of monoamine activity in patients with schizophrenia, (e.g. inverse correlation of the dopamine metabolite HVA with delusions or visual-masking performance). However, profiles (as presented here) of the relations of the activity of dopamine, noradrenaline and serotonin to neuropsychologic (dys)functions in major patient sub-groups with their very different symptomatic and cognitive characteristics have not been reported.

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Factors associated with increased noradrenaline levels in schizophrenic patients

Cited by 35 publications

References 46 publications

Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17

Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity

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