Factors associated with in-hospital mortality among critically ill surgical patients with multidrug-resistant Gram-negative infections

Ethics of Infection Control Measures for Carriers of Antimicrobial Drug–Resistant Organisms

“…What remains ethically noteworthy and relevant for preemptive and reactive AMR control strategies is that, although all carriers are at risk for their carriage resulting in clinical infection, multidrug-resistant organisms primarily threaten a specific subgroup of vulnerable patients in hospital settings. The extent to which multidrug-resistant organisms contribute to death has been debated and seems to remain limited to those with severe illness and concurrent conditions ( 28 – 30 ). Studies addressing multidrug-resistant gram-negative infections, for instance, show substantial diversity in the outcomes.…”

“…Studies addressing multidrug-resistant gram-negative infections, for instance, show substantial diversity in the outcomes. It can be concluded that mortality rates are higher among those infected by multidrug-resistant gram-negative bacteria; however, concurrent conditions and severity scores are more commonly identified as predictors of death ( 28 – 30 ). From a broader public health perspective, the health threat of multidrug-resistant organism carriage thus appears limited.…”

“…Control measures for most communicable diseases therefore aim to regulate these threats ( 25 ). Outbreaks of multidrug-resistant organism infections, however, do not cause high morbidity and mortality rates ( 21 , 28 – 30 ). Public health measures aim to prevent introduction and further transmission of multidrug-resistant organisms in (some) healthcare-associated settings ( 2 ).…”

Treatment and mortality of Klebslella pneumoniae infections in critically ill patients: should we do and predict them better?

“…The incidence of severe infections caused by Gram negative bacteria continues to increase, particularly with advances in medical care, and remains a major contributor to morbidity and mortality with variation between countries and between hospitals [1,2]. The variable mortality rates of patients with severe infections caused by Gram negative bacteria depends largely on antibiotic resistance but also on differences involving the populations analyzed, including those related to age and underlying disease/comorbidity profiles [3]. Among Enterobacteriaceae, Klebsiella pneumoniae (Kp) is largely prevalent in patients admitted to acute and long-term care facilities, and has an outstanding propensity to develop antibiotic resistance [4].…”

The Effect of Carbapenem Restriction Policy on the Rate of Hospital Infections Due To Resistant Microorganisms in the Intensive Care Unit

“…Nosocomial infections due to resistant gram-negative bacteria have become a major problem in the intensive care units (ICU) worldwide. These infections may result in the development of treatment difficulties of patients, prolonged intensive care stay, increased morbidity, mortality, and treatment cost (1). The most common difficulty for the treatment of resistant microorganisms is the inability to receive appropriate antibiotic therapy (2).…”