Factors Associated With Impaired Kidney Function and Its Impact on Long-Term Outcome in Young Ischemic Stroke

Self Cite

Background and Purpose-We aimed to explore clinical features of young patients with ischemic stroke with no traditional vascular risk factors and to assess the impact of risk factor counts on outcomes. Methods-We included 990 patients aged 15 to 49 years with first-ever ischemic stroke followed for a mean of 9.0Ϯ3.8 years (survivors). Risk factors were categorized as well-documented and less well-documented. Outcome measures were unfavorable functional outcome (3-month modified Rankin Scale 2-6); recurrent ischemic stroke; myocardial infarction or other arterial noncerebrovascular event; and death from any cause. Results-Compared

Section: Discussionsupporting

confidence: 54%

How Does Number of Risk Factors Affect Prognosis in Young Patients With Ischemic Stroke?

Putaala

Haapaniemi

Kaste

et al. 2012

Self Cite

“…One reason for this finding could be that our patient cohort was older than that in other studies. 13,15 The link between age and both decreased kidney function and WMD severity is well established. 38 The possible age-related GFR reduction in our cohort could have been understated by the higher age in our cohort.…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Hemoglobin A1c Are Associated With Cerebral White Matter Disease in Patients With Stroke

Różański

Richter

Grittner³

et al. 2014

Background and Purpose-This study was conducted to investigate the association of cerebral white matter disease (WMD) on MRI with vascular risk factors and laboratory findings in consecutive first acute ischemic stroke patients. Methods-Acute ischemic stroke patients underwent MRI ≤24 hours after stroke onset and follow-up on day 2. WMD was scored on fluid attenuated inversion recovery MRI according to the Wahlund score.

“…2 Kidney dysfunction, characterized by low estimated glomerular filtration rate (eGFR), is not only associated with all-cause and cardiovascular mortality in general population but also linked with long-term clinical outcomes in patients with stroke. [3][4][5] However, whether the link between reduced eGFR and outcomes after acute stroke could be modified by the presence or absence of some particular diseases is still uncertain.…”

mentioning

confidence: 99%

Associations Between Estimated Glomerular Filtration Rate and Stroke Outcomes in Diabetic Versus Nondiabetic Patients

Luo

Wang

Matsushita

et al. 2014

Background and Purpose-Low estimated glomerular filtration rate (eGFR) is known to be associated with clinical adverse outcomes. However, whether diabetes mellitus influences the association between eGFR and prognosis of stroke is still not elucidated. Methods-Prospective cohort of 17 280 (nondiabetic 12 498 and diabetic 4782) Chinese patients with acute stroke from the China National Stroke Registry and from abnormal glucose regulation in patients with acute stroke across China (ACROSS) between 2007 and 2009 were followed-up for 1 year for all-cause mortality, stroke recurrence, and stroke disability related to baseline eGFR in the presence and absence of diabetes mellitus. Results-Among nondiabetic patients, as compared with eGFR of 90 to 119 mL/min per 1.73 m 2 , the adjusted odds ratio of lower eGFR of < 45 mL/min per 1.73 m 2 was 2.79 (95% confidence interval, 2.09-3.73) for all-cause mortality, 2.28 (1.74-2.98) for stroke recurrence, and 1.53 (1.16-2.01) for stroke disability; higher eGFR of ≥120 mL/min per 1.73 m 2 was just significantly associated with higher risk of all-cause mortality (odds ratio, 1.38; 95% confidence interval, 1.02-1.86) but not with other outcomes. In diabetic patients, the adjusted odds ratios of all-cause mortality, stroke recurrence, and stroke disability in lower eGFR were 2.16 (1.51-3.08), 1.43 (1.02-2.00), and 1.38 (0.98-1.95), respectively; higher eGFR was significantly associated with higher risks of all stroke outcomes.