Factors associated with heart failure hospitalization in patients with high sodium excretion: subanalysis of the ESPRIT, evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients, cohort study

Sadanaga, Tsuneaki; Hirota, Shinichi; Mitamura, Hideo

doi:10.1007/s00380-020-01673-2

Cited by 4 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the efficacy of urinary sodium as a biomarker of HF is more complicated than it initially appears ( 16 ). In the present and previous study ( 10 ), the Na/Cr ratio and sodium excretion ≥4.0 g/day were not associated with HF hospitalization in patients with stable HF patients ( Fig. 3A , and ref 10 ).…”

Section: Discussionsupporting

confidence: 54%

“…In the present and previous study ( 10 ), the Na/Cr ratio and sodium excretion ≥4.0 g/day were not associated with HF hospitalization in patients with stable HF patients ( Fig. 3A , and ref 10 ). The LVEF was reduced in the majority (86%) of the patients in the study by Martens et al ( 15 ), whereas, the LVEF was preserved in the majority (72%) of the patients in the present study; this may have contributed to the difference in the results.…”

Section: Discussionsupporting

confidence: 54%

“…On the other hand, a sodium excretion ≥4.0 g/day assessed using the method of Tanaka et al ( 5 ) was associated with hospitalization for HF only following adjustment for age, sex and body weight. This may be due to the fact that high sodium excretion is associated with hospitalization for HF in patients of an older age, of the female sex and a low body weight, as previously reported ( 10 ). Of note, appropriate sodium intake in these populations is not yet well understood.…”

Section: Discussionmentioning

confidence: 53%

See 2 more Smart Citations

Sodium to creatinine ratio in spot urine is associated with heart failure hospitalization in Japanese high‑risk patients

Sadanaga¹,

Hirota

2022

Exp Ther Med

Self Cite

View full text Add to dashboard Cite

Our previous study [Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients (ESPRIT study)] reported that increased sodium excretion ≥4.0 g/day was associated with composite cardiovascular events in hospitalization for heart failure (HF), acute coronary syndrome, cerebrovascular events and documented cardiovascular-related mortality in Japanese high-risk patients with either stable and compensated HF, coronary artery disease, cerebrovascular disease, chronic kidney disease or atrial fibrillation. However, the method of estimating sodium excretion levels using spot urine is complex, requiring age, body weight, height and multiplier factors for calculation. The aim of the present study was to elucidate whether the sodium to creatinine ratio in spot urine, a key component in estimating daily sodium excretion, was associated with hospitalization for HF. The present study performed a post-hoc analysis of the ESPRIT study (n=520; 60 hospitalizations for HF). Receiver operating curve analysis yielded an optimal sodium to creatinine ratio cut-off value of 24.8 for detecting hospitalization for HF. Kaplan-Meier curve analysis revealed that a high sodium to creatinine ratio in spot urine was associated with an increased hospitalization for HF (P<0.001). Cox regression analysis revealed that a high sodium to creatinine ratio was associated with hospitalization for HF with a hazard ratio (HR) of 2.49 [95% confidence interval (95% CI), 1.47-4.16]. Following adjustment for age, sex and body weight, the HR was as high as 2.74 (95% CI, 1.51-4.71). This association remained following further adjustment for brain natriuretic peptide, estimated glomerular filtration rate, diabetes mellitus or the use of diuretics. Overall, the present study demonstrated that the sodium to creatinine ratio in spot urine is associated with hospitalization for HF in Japanese high-risk patients.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Sodium to creatinine ratio in spot urine is associated with heart failure hospitalization in Japanese high‑risk patients

Sadanaga¹,

Hirota

2022

Exp Ther Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Amongst the studies, a variety of outcomes were assessed. Category I mortality and incident CVD [ 25 ], Category II composite CVD [ 26 ] and Category III with the outcome of physical performance [ 27 ] had one study each. Category IV included the largest number of studies ( n = 19), all of which assessed BP outcomes [ 28 – 46 ].…”

Section: Resultsmentioning

confidence: 99%

The World Hypertension League Science of Salt: a regularly updated systematic review of salt and health outcomes studies (Sept 2019 to Dec 2020)

et al. 2022

View full text Add to dashboard Cite

The World Hypertension League Science of Salt health outcomes review series highlights high-quality publications relating to salt intake and health outcomes. This review uses a standardised method, outlined in previous reviews and based on methods developed by WHO, to identify and critically appraise published articles on dietary salt intake and health outcomes. We identified 41 articles published between September 2019 to December 2020. Amongst these, two studies met the pre-specified methodological quality criteria for critical appraisal. They were prospective cohort studies and examined physical performance and composite renal outcomes as health outcomes. Both found an association between increased/higher sodium intake and poorer health outcomes. Few studies meet criteria for high-quality methods. This review adds further evidence that dietary salt reduction has health benefits and strengthens evidence relating to health outcomes other than blood pressure and cardiovascular disease. We observe that most studies on dietary sodium do not have adequate methodology to reliably assess sodium intake and its association with health outcomes.

show abstract

“…A report including a very large number of participants ( n = 478,311) of the UK Biobank revealed an inverse association between the urine sodium–potassium ratio (UNa/UK) from random spot measurements and CAD [ 59 ]. A post hoc analysis of the ESPRIT study ( n = 520 patients) showed that high sodium levels from measurements of spot urine (UNa ≥ 4 g/day) were associated with HF hospitalization, but not with other CV adverse outcomes [ 60 ]. On the other hand, as far as the serum measurements of sodium are concerned, a longitudinal observational study of 3558 patients with incident acute MI demonstrated that hyponatremia on admission (Na < 136 mmol/L) was a predictor of mortality [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Emerging Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease

Pál

Bărcuțean

Lupu

et al. 2023

Life

View full text Add to dashboard Cite

Cardiovascular disease is most frequently caused by the development and progression of atherosclerosis. When coronary arteries are afflicted, and the stenoses caused by atherosclerotic plaques are severe enough, the metabolic supply-and-offer balance is disturbed, leading to myocardial ischemia. If atherosclerotic plaques become unstable and local thrombosis develops, a myocardial infarction occurs. Sometimes, myocardial ischemia and infarction may result in significant and irreversible heart failure. To prevent severe complications, such as acute coronary syndromes and ischemia-related heart failure, extensive efforts have been made for developing biomarkers that would help identify patients at increased risk for cardiovascular events. In this two-part study, we attempted to provide a review of existing knowledge of blood biomarkers that may be used in this setting. The first part of this work was dedicated to conventional biomarkers, which are already used in clinical practice. In the second part, here presented, we discuss emerging biomarkers which have not yet become mainstream.

show abstract

Factors associated with heart failure hospitalization in patients with high sodium excretion: subanalysis of the ESPRIT, evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients, cohort study

Cited by 4 publications

References 10 publications

Sodium to creatinine ratio in spot urine is associated with heart failure hospitalization in Japanese high‑risk patients

Sodium to creatinine ratio in spot urine is associated with heart failure hospitalization in Japanese high‑risk patients

The World Hypertension League Science of Salt: a regularly updated systematic review of salt and health outcomes studies (Sept 2019 to Dec 2020)

Emerging Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease

Contact Info

Product

Resources

About