Factors associated with glycemic variability in Japanese patients with diabetes

Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes

“…Recent studies suggest that the effect of treatment strategy on glycemic variability is relatively small [9,10,33,34]. Whether this was due to insufficient control of glycemic variability with current therapy or to other factors affecting GA/HbA1c should be addressed in future prospective studies.…”

Relationships among different glycemic variability indices obtained by continuous glucose monitoring

“…Characteristics of the patients are described elsewhere [14] and in Table 1. Of these patients, two had liver cirrhosis and four had autoimmune thyroid disease, but none had nephrotic syndrome or end-stage renal disease, severe anemia, erythropoietin treatment or glucocorticoid treatment.…”

“…All measurements were performed by the Department of Laboratory Medicine, Keio University School of Medicine with routine automated laboratory methods as previously described [14]. HbA1c was measured on the day of admission by HPLC and expressed as the National Glycohemoglobin Standardization Program (NGSP) value according to the JDS statement [16].…”

“…CGM was performed using a CGMS Gold (Medtronic Minimed, Northridge, CA, USA), as previously reported [14]. After treating hyperglycemia during admission (i.e., usually for 7-10 days after admission), CGM was performed for 2-4 days before discharge.…”

“…Moreover, because SD and mean glucose were also correlated with each other [13,14], the relationships among the indices are more complicated.…”