Factors Associated with Glaucoma after Penetrating Keratoplasty

Karesh, James W.; Nirankari, Verinder S.

doi:10.1016/s0002-9394(14)77783-9

Cited by 87 publications

(46 citation statements)

References 9 publications

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“…Our results confirmed the poor prognosis of eyes with post-graft glaucomatous pathology [10,13,18]. The 10-year survival probability of eyes with post-operative glaucomatous pathology is 10%, against 52% for glaucoma-free eyes (P=0.03) (Fig.…”

Section: Discussionsupporting

confidence: 85%

Long-term results of penetrating keratoplasty

Muraine

Sanchez

Watt

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussionsupporting

confidence: 85%

Long-term results of penetrating keratoplasty

Muraine

Sanchez

Watt

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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“…The reported incidence of secondary glaucoma after PKP ranges 10-53%. [33][34][35][36][37] One subject (7.1%, Patient 13) suffered from secondary glaucoma with painful red eye and no light perception and received evisceration at 39 month follow-up.…”

Section: Resultsmentioning

confidence: 99%

Eye preservation tectonic graft using glycerol-preserved donor cornea

Hc¹,

Sj²,

Chao³

2012

Eye

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Aims To report the surgical outcome of tectonic graft using glycerol-preserved donor corneas to treat perforated keratitis. Methods The medical records were reviewed of all patients treated for perforated keratitis using glycerol-preserved corneas at a single institution between 1 July 2004 and 31 June 2010. The clinical features, precipitating factors, adjuvant therapies, and therapeutic outcomes were analyzed. Success was defined as re-epithelialization of the ocular surface without evisceration. Results Fourteen eyes from 14 patients (6 male and 8 female) were included. Age ranged from 58 to 84 years (average, 70.71±8.52 years) and the follow-up time ranged from 7 to 56 months (mean, 25.35 ± 16.84 months). The culture results showed five bacterial infections, five cases of fungal keratitis, and one mixed infection; the culture results were negative for three patients. Satisfactory anatomical integrity was obtained in eight grafts (57.14%) that healed with neovascularization. Six grafts (48.85%) showed delayed re-epithelialization and were repaired with conjunctival flaps to maintain ocular surface integrity. Three patients developed secondary glaucoma and received trans-scleral cyclophotocoagulation. Thirteen patients had satisfactory anatomical integrity without evisceration or exenteration, while one patient received evisceration at 39-month follow-up because of intractable glaucoma. Conclusions Glycerol-preserved donor corneas combined with anterior vitrectomy with or without conjunctival flaps may be effective substitutes for evisceration surgery in patients with perforated keratitis.

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“…Increased IOP develops most frequently after PKP for ABK and less frequently for eyes with Fuchs' corneal dystrophy and keratoconus. [19][20][21][22][23][24][25][26][27] In a series of 502 corneal transplant patients reported by Foulks in 1987, glaucoma developed in 18% of all patients studied: 39% in patients who were aphakic, 8% in patients who had no history of glaucoma, and 80% in patients who had a prior history of glaucoma. 19 In a series of 1122 patients from 1992, Kirkness and Ficker 23 reported that 1% of patients with keratoconus, 3% of patients with corneal dystrophies, and 29% of patients with bullous keratopathy developed elevated IOP following PKP.…”

Section: Trends In Corneal Transplant Surgerymentioning

confidence: 99%

“…21 Other risk factors for the development of glaucoma after PKP include pre-existing glaucoma, the presence of peripheral anterior synechiae, corneal re-grafting, a history of ocular trauma, and combined PKP and cataract extraction surgery. 19,[21][22][23]28,29 Simmons reported a fourfold increased relative risk for developing glaucoma post-keratoplasty in patients with pre-existing glaucoma vs those without a prior history of glaucoma. 30 Sihota reported a post-keratoplasty incidence of glaucoma of 10.6% in his series of 747 patients, 13% of whom underwent repeat PK for a failed corneal graft.…”

Section: Trends In Corneal Transplant Surgerymentioning

confidence: 99%

Management of patients with combined glaucoma and corneal transplant surgery

Banitt

Lee

2009

Eye

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Penetrating keratoplasty (PKP) is associated with an increased risk of secondary glaucoma. The development of glaucoma after PKP is an important risk factor for decreased corneal graft survival. The incidence of glaucoma after corneal transplant as well as the mechanism of developing increased intraocular pressure is reviewed in this paper. Treatments for post-PKP glaucoma include medications, laser, and surgery. The most frequent surgical glaucoma intervention is implantation of a glaucomadrainage device. Recent advances in corneal transplantation surgery may help to decrease corneal failure and the risk of developing post-keratoplasty glaucoma.

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Factors Associated with Glaucoma after Penetrating Keratoplasty

Cited by 87 publications

References 9 publications

Long-term results of penetrating keratoplasty

Long-term results of penetrating keratoplasty

Eye preservation tectonic graft using glycerol-preserved donor cornea

Management of patients with combined glaucoma and corneal transplant surgery

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