Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital, Accra, Ghana

Archampong, Timothy; Asmah, Richard Harry; Wiredu, Edwin K.; Gyasi, Richard K.; Nkrumah, K.N.

doi:10.4314/ahs.v16i2.32

Cited by 12 publications

(20 citation statements)

References 19 publications

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“…In addition, 66% of the patients indicated NSAID use, 89% alcohol intake of >5 units/d, 55.3% fasting or irregular eating and 61.9% were H. pylori positive . Another smaller study from Ghana provided similar results, that is, H. pylori being the leading risk factor for PUD, yet NSAID‐related injury being common in H. pylori infected individuals …”

Section: Helicobactor Pylori and Peptic Ulcer Diseasementioning

confidence: 81%

“…2 Another smaller study from Ghana provided similar results, that is, H. pylori being the leading risk factor for PUD, yet NSAID-related injury being common in H. pylori infected individuals. 3 The recurrence of PUD depending on the H. pylori status was analyzed in a retrospective multicentric study in Korea involving 1,761 patients. 4 As anticipated, the 5 year cumulative probability of PUD recurrence was high in the group which had not received eradication treatment (43.8%).…”

Section: Helicobactor Pylori and Peptic Ulcer Diseasementioning

confidence: 99%

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Helicobacter pylori infection and nonmalignant diseases

et al. 2017

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A substantial decrease in Helicobacter pylori-associated peptic ulcer disease has been observed during the last decades. Drug-related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. The effect of H. pylori eradication upon functional dyspepsia symptoms has been reviewed in this article and generally confirms the results of previous meta-analyses. Additional evidence suggests a lack of impact upon the quality of life, in spite of improvement in symptoms. The association of H. pylori with gastroesophageal reflux disease and Barrett's esophagus remains controversial with a majority of published studies showing a negative association. Furthermore, a strong inverse relationship between the presence of H. pylori and the esophageal eosinophilia was also reported. Several studies and a review addressed the role of H. pylori in autoimmune gastritis and pernicious anemia. The association of the above still remains controversial. Finally, the necessity of routine endoscopy and H. pylori eradication before bariatric surgery is discussed. Several studies suggest the rationale of preoperative upper endoscopy and H. pylori eradication prior to surgery. However, the prevalence of H. pylori infection prior to surgery in these studies generally reflects the overall prevalence of the infection in the particular geographic area. In addition, results on the role of H. pylori in developing postoperative complications remain controversial.

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Section: Helicobactor Pylori and Peptic Ulcer Diseasementioning

confidence: 81%

Section: Helicobactor Pylori and Peptic Ulcer Diseasementioning

confidence: 99%

Helicobacter pylori infection and nonmalignant diseases

et al. 2017

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“…For instance, a study on the prevalence of dyspepsia in rural Northeastern Nigeria demonstrated that over 50% of dyspeptic patients sought medical help mainly from traditional healers[2]. These observations and tendancies are thought to have resulted in the reported prevalence of peptic ulcer disease (PUD) and gastric cancer (GCA) in Africa being significantly lower than that in other areas of the world[3].…”

Section: Introductionmentioning

confidence: 99%

“…This subsequently leads to a variety of empirical therapies for symptomatic individuals further delaying definitive diagnosis, and thereby contributing to the observed low prevalence of GDD in some areas[1,5]. Following the increasing availability of flexible upper GI endoscopy over recent years, it has now become apparent that GDD is prevalent across the continent of Africa[1,3]. Currently, in Ghana, there are endoscopic services and CT scan facilities in tertiary medical centres but not at most regional or district hospitals.…”

Section: Introductionmentioning

confidence: 99%

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

Archampong

Asmah

Richards

et al. 2019

WJG

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Gastroduodenal disease (GDD) was initially thought to be uncommon in Africa. Amongst others, lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world. Following the increasing availability of flexible upper gastro-intestinal endoscopy, it has now become apparent that GDD, especially peptic ulcer disease (PUD), is prevalent across the continent of Africa. Recognised risk factors for gastric cancer (GCA) include Helicobater pylori ( H. pylori ), diet, Epstein-Barr virus infection and industrial chemical exposure, while those for PUD are H. pylori , non-steroidal anti-inflammatory drug (NSAID)-use, smoking and alcohol consumption. Of these, H. pylori is generally accepted to be causally related to the development of atrophic gastritis (AG), intestinal metaplasia (IM), PUD and distal GCA. Here, we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy, and complement the analysis with new data obtained on pre-malignant gastric his-topathological lesions in Accra, Ghana which was compared with previous data from Maputo, Mozambique. As there is a general lack of structured cohort studies in Africa, we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals. In Africa, there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns. Furthermore, there are differences in PUD within-country despite universally endemic H. pylori infection. PUD is not uncommon in Africa. Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries. An additional intriguing observation is a recent, ongoing decline in PUD in some African countries where H. pylori infection is still high. One possible reason for the high, sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations. The prevalence of AG and IM, were similar or modestly higher over rates in western countries but lower than those seen in Asia. . In our new data, sampling of 136 patients in Accra detected evidence of pre-malignant lesions (AG and/or IM) in 20 individuals (14.7%). Likewise, the prevalence of pre-malignant lesions, in a sample of 109 patients from Maputo, were 8.3% AG and 8.3% IM. While H. pylori is endemic in Africa, the observed prevalence for GCA is rather low. However, cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems, diagnostic health facilities and expertise. Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of G...

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“…29 The section concludes a much awaited paper from Gabon: Cerebrospinal meningeal infections in HIV-infected patients. 30 We have a paper on upper GIT endoscopy 31 , while the next set of papers is on herbal remedies. 32 …”

Section: Infections: Preventionmentioning

confidence: 99%

From MNHC, NCDs to prevention of infectious diseases and plantibodies: meeting challenges of our times

Tumwine¹

2016

Afr H. Sci.

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Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital, Accra, Ghana

Cited by 12 publications

References 19 publications

Helicobacter pylori infection and nonmalignant diseases

Helicobacter pylori infection and nonmalignant diseases

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

From MNHC, NCDs to prevention of infectious diseases and plantibodies: meeting challenges of our times

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