Factors associated with fluorine-18-fluorodeoxyglucose uptake in benign thyroid nodules

Ohba, Kenji; Sasaki, Shigekazu; Osuga, Yutaka; Nishizawa, Sadahiko; Matsushita, Akio; Yoshino, Akira; Suda, Takafumi; Nakamura, Hirotoshi

doi:10.1507/endocrj.ej13-0155

Cited by 6 publications

(2 citation statements)

References 26 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies also reported a similar percentage of patients with incidentally discovered thyroid PET lesions who were further investigated, with follow-up rates in the ranks of 50%. 11 – 13 , 16 – 18 , 23 – 25 , 28 …”

Section: Discussionmentioning

confidence: 99%

“…This finding is quite different from data published in the literature. 18 , 23 Our explanation for this discrepancy is in the different diagnostic process that was used in different institutions. At UMC, a thorough thyroid examination with relevant laboratory workup and an ultrasound examination of the thyroid, irrespective of the use of FNAC, was in most patients enough to make a final diagnosis of thyroid disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study

Jamšek¹,

Žagar

Gaberšček

et al. 2015

Radiology and Oncology

View full text Add to dashboard Cite

Background.Incidental 18F-FDG uptake in the thyroid on PET-CT examinations represents a diagnostic challenge. The maximal standardized uptake value (SUVmax) is one possible parameter that can help in distinguishing between benign and malignant thyroid PET lesions.Patients and methods.We retrospectively evaluated 18F-FDG PET-CT examinations of 5,911 patients performed at two different medical centres from 2010 to 2011. If pathologically increased activity was accidentally detected in the thyroid, the SUVmax of the thyroid lesion was calculated. Patients with incidental 18F-FDG uptake in the thyroid were instructed to visit a thyroidologist, who performed further investigation including fine needle aspiration cytology (FNAC) if needed. Lesions deemed suspicious after FNAC were referred for surgery.Results.Incidental 18F-FDG uptake in the thyroid was found in 3.89% — in 230 out of 5,911 patients investigated on PET-CT. Malignant thyroid lesions (represented with focal thyroid uptake) were detected in 10 of 66 patients (in 15.2%). In the first medical centre the SUVmax of 36 benign lesions was 5.6 ± 2.8 compared to 15.8 ± 9.2 of 5 malignant lesions (p < 0.001). In the second centre the SUVmax of 20 benign lesions was 3.7 ± 2.2 compared to 5.1 ± 2.3 of 5 malignant lesions (p = 0.217). All 29 further investigated diffuse thyroid lesions were benign.Conclusions.Incidental 18F-FDG uptake in the thyroid was found in 3.89% of patients who had a PET-CT examination. Only focal thyroid uptake represented a malignant lesion in our study — in 15.2% of all focal thyroid lesions. SUVmax should only serve as one of several parameters that alert the clinician on the possibility of thyroid malignancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study

Jamšek¹,

Žagar

Gaberšček

et al. 2015

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

2-[18F]FDG PET Imaging of Infection and Inflammation

Minamimoto

2021

Nuclear Medicine and Immunology

View full text Add to dashboard Cite

Utility of PET/Computed Tomography in Infection and Inflammation Imaging

2022

View full text Add to dashboard Cite

Factors associated with fluorine-18-fluorodeoxyglucose uptake in benign thyroid nodules

Cited by 6 publications

References 26 publications

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study

2-[18F]FDG PET Imaging of Infection and Inflammation

Utility of PET/Computed Tomography in Infection and Inflammation Imaging

Contact Info

Product

Resources

About

Factors associated with fluorine-18-fluorodeoxyglucose uptake in benign thyroid nodules

Cited by 6 publications

References 26 publications

Thyroid lesions incidentally detected by 18F-FDG PET-CT ― a two centre retrospective study

Thyroid lesions incidentally detected by 18F-FDG PET-CT ― a two centre retrospective study

2-[18F]FDG PET Imaging of Infection and Inflammation

Utility of PET/Computed Tomography in Infection and Inflammation Imaging

Contact Info

Product

Resources

About

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study

Thyroid lesions incidentally detected by ¹⁸F-FDG PET-CT ― a two centre retrospective study