Factors Associated with Fatality during the Intensive Phase of Anti-Tuberculosis Treatment

Rodrigo, Teresa; Casals, Martí; Caminero, José A.; García-García, José María; Jiménez-Fuentes, María Ángeles; Medina, Juan F.; Millet, Joan-Pau; Ruiz-Manzano, Juan; Caylà, J A

doi:10.1371/journal.pone.0159925

Cited by 15 publications

(18 citation statements)

References 25 publications

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“…First important finding of current study was the higher rate of mortality in PTB patients i.e., 13.5%, whereas most of the other studies reported the lower mortality prevalence than current study such as Asgedom SW et al, 11.3%,17 Shahrezaei M et al, 1.6%,18 and Rodrigo T et al, 3.5% 19. Another study by Takarinda KC et al reported the higher prevalence of mortality 22.0% in TB patients 20.…”

Section: Discussioncontrasting

confidence: 44%

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Hameed

Zuberi²,

Hussain

et al. 2019

Pak J Med Sci

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Objective: To evaluate risk factors having significant effect on mortality of smear positive Pulmonary Tuberculosis (PTB) inpatients. Methods: A descriptive cross-sectional study was conducted at Ojha Institute of Chest Diseases, Dow University Hospital Ojha Campus, Karachi. One hundred and seventy (170) inpatients of smear positive PTB confirmed by Acid Fast Bacilli (AFB) smear, aged between 13-80 years were enrolled by using consecutive sampling technique while patients with drug resistant Tuberculosis (TB) and extra pulmonary TB were excluded from the study. Selected patients were interviewed for collecting demographic data and risk factor data by using a standard questionnaire. Results: Out of 170 PTB inpatients, mortality was observed in 23 (13.5%) patients among which male patients were 12 (52.2%), and female were 11 (47.8%). Mortality was significantly associated with increasing age (p=0.003), socioeconomic status (p=0.019), anemia (p=0.03), Chronic Liver Disease (CLD) (p=0.005), Diabetes Mellitus (DM) (p=0.001), Human Immunodeficiency Virus (HIV) (p=0.007), Hypertension (HTN) (p=0.006), recurrent TB (p=0.001), and smoking (p=0.001). Conclusion: Increasing age, poverty, smoking history, and presence of comorbidities like DM, CLD, HIV, hypertension, and anemia are associated with higher mortality in smear positive PTB cases. doi: https://doi.org/10.12669/pjms.35.5.919 How to cite this:Hameed S, Zuberi FF, Hussain S, Ali SK. Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.919 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 44%

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Hameed

Zuberi²,

Hussain

et al. 2019

Pak J Med Sci

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“…A medida que aumenta la edad se incrementa el riesgo de fallecer por TB, esto puede deberse a comorbilidades y al declive natural de la inmunidad, la respuesta inmunitaria se va deteriorando y esto contribuye a la reactivación de la TB latente, lo que hace más propensos a desarrollar la enfermedad. Esto, sumado al diagnóstico tardío, aumenta la posibilidad de un desenlace fatal (22, 23).…”

Section: Discussionunclassified

Factores asociados a la mortalidad por tuberculosis en Paraguay, 2015-2016

Medina

López

Martínez

et al. 2019

Revista Panamericana De Salud Pública

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RESUMENObjetivo.Describir las características sociodemográficas y clínico-epidemiológicas y determinar los factores asociados a la mortalidad de personas con diagnóstico de tuberculosis en Paraguay.Métodos.Investigación operativa con un diseño de cohortes retrospectivo de los casos diagnosticados con TB en Paraguay entre 2015-2016. Se utilizó la base datos del Programa Nacional de Control de Tuberculosis. Para determinar los factores asociados con mortalidad se utilizaron pruebas chi cuadrado y riesgo relativo (RR) con un intervalo de confianza de 95% (IC95%); además, se ajustó un modelo de regresión múltiple de Poisson robusto. Se utilizó un nivel de significación de 5%.Resultados.Se estudiaron 5 141 casos de TB, de los cuales 11,5% fallecieron, los factores que aumentan el riesgo de muerte fueron: sexo masculino (RR: 1,26 IC; 95%: 1,1-1,50), infección con virus de la inmunodeficiencia humana (VIH) (RR: 4,78; IC 95%: 4,04-5,65) y enfermedad pulmonar obstructiva crónica (RR: 1,70; IC 95%: 1,19-2,42). Como factor protector se identificó ser persona privada de la libertad (RR: 0,37 IC 95%: 0,24-0,61).Conclusiones.El mayor riesgo de muerte lo presentan los hombres y las personas con coinfección TB/VIH y el menor riesgo, las personas privadas de la libertad. Es necesario mejorar el diagnóstico y seguimiento a los casos de TB, con la efectiva implementación del tratamiento directamente observado (TDO) así como el manejo oportuno de enfermedades asociadas como VIH y enfermedad pulmonar obstructica crónica (EPOC).

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“…Admission to a hospital with an ER on site was a highly relevant risk predictor for death, suggesting there can be barriers to accessing care and to adequate and timely treatment at the outpatient clinics, as would be expected due to certain limitations at these facilities versus hospitals. The start of treatment could therefore be delayed, possibly leading to a more severe case of TB, which, in turn, would increase the chance of complications that could affect mortality (29).…”

Section: Discussionmentioning

confidence: 99%

Effect of inpatient and outpatient care on treatment outcome in tuberculosis: a cohort study

Rocha

Oliveira

Saraceni

et al. 2018

Rev Panam Salud Publica

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Objective To identify individual- and health services–related factors associated with deaths in subjects diagnosed with tuberculosis (TB). Methods A nonconcurrent cohort study with passive follow-up was conducted using a probabilistic linkage method to analyze a sample of patients diagnosed and reported as having TB in 2006 and followed up until 2008. New cases, cases with previous treatment (readmission after loss to follow-up or relapse), and transfers across health services were included. Proportional hazards models were used to estimate the independent effect of covariates related to the individual and to the health services on mortality from all causes. Results Age above 60 years, admission to a hospital with emergency services, HIV-associated TB, and readmission to an outpatient facility after disease relapse or loss to follow-up were identified as risk factors for death. Variables related to process and results indicators of Brazil's National TB Program were not associated with mortality from all causes. Conclusions Advanced age, previous treatment for TB, and treatment at a secondary-level outpatient facility or a hospital with emergency services on site were associated with mortality in TB patients. Better strategies to improve TB care delivered at health units are needed to prevent death from TB, especially among the elderly.

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Factors Associated with Fatality during the Intensive Phase of Anti-Tuberculosis Treatment

Cited by 15 publications

References 25 publications

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Factores asociados a la mortalidad por tuberculosis en Paraguay, 2015-2016

Effect of inpatient and outpatient care on treatment outcome in tuberculosis: a cohort study

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