Factors associated with failure of medical therapy in patients with unstable angina and non-Q wave myocardial infarction. A TIMI-IIIB database study

Abstract

Baseline characteristics associated with developing a clinical event or a markedly abnormal risk stratifying test were similar: rest anginal episode accompanied by ST-segment depression and occurring despite treatment with aspirin and heparin, a history of angina, older age, and family history of coronary disease. Patients with these characteristics are appropriate candidates for expeditious cardiac catheterization and consideration for revascularization, while patients without them may be suitable for medical management alone.

2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

“…Older trials included TIMI IIIB, 129,561 Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH), 534 and Medicine versus Angiography in Thrombolytic Exclusion (MATE). 533 More recent trials, relevant to contemporary practice, include FRISC-II, 245 TACTICS-TIMI 18, 182 VINO, 522 RITA-3, 546 ISAR-COOL, 540 and ICTUS; 532 a large, prospective, multinational registry, the OASIS registry; 559 and several metaanalyses.…”

ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

“…Older trials included TIMI IIIB (129,561), Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) (534), and Medicine versus Angiography in Thrombolytic Exclusion (MATE) (533). More recent trials, relevant to contemporary practice, include FRISC-II (245), TACTICS-TIMI 18 (182), VINO (522), RITA-3 (546), ISAR-COOL (540), and ICTUS (532); a large, prospective, multinational registry, the OASIS registry (559); and several meta-analyses (542)(543)(544).…”

2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

“…Older trials included TIMI IIIB, 136,650 Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH), 621 and Medicine versus Angiography in Thrombolytic Exclusion (MATE). 620 More recent trials, relevant to contemporary practice, include FRISC-II, 251 TACTICS-TIMI 18, 188 VINO, 640 RITA-3, 633 ISAR-COOL, 624 and ICTUS 436 ; a large, prospective, multinational registry, the OASIS registry 649 ; and several meta-analyses.…”