Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer

Deng, Jie; Ridner, Sheila H.; Dietrich, Mary S.; Wells, Nancy; Wallston, Kenneth A.; Sinard, Robert J.; Cmelak, Anthony J.; Murphy, Barbara A.

doi:10.1016/j.ijrobp.2012.04.013

Cited by 68 publications

(68 citation statements)

References 16 publications

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“…[6][7][8] A previous cross-sectional study found that lymphedema may develop externally (e.g., face and neck) and/or internally (e.g., larynx and pharynx) in patients with HNC. 9 Data indicate that lymphedema correlates with the symptom burden and functional deficits that have plagued HNC survivors. 10 Despite the potential of lymphedema and fibrosis to negatively influence patients' outcomes, they remain underrecognized and undertreated by clinicians.…”

mentioning

confidence: 94%

A Prospective Study of the Lymphedema and Fibrosis Continuum in Patients with Head and Neck Cancer

Ridner

Dietrich

Niermann

et al. 2016

Lymphatic Research and Biology

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105

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Background: The purpose of this study was to determine the prevalence and nature of internal, external, and combined lymphedema and fibrosis in patients with head and neck cancer (HNC). Materials and Methods: We obtained consent from 100 patients newly diagnosed with having cancer of the head and neck for a 4-year, prospective, longitudinal descriptive study. Recruitment began in August 23, 2010, and the study was completed in April 24, 2014. Eighty-three were evaluated at regular intervals from preradiation therapy to 18 months post-treatment. Percentage developing external, internal, or both types of lymphedema and/or fibrosis and trajectories of the severity of external, internal, or both types of lymphedema and/or fibrosis were determined. Results: Before treatment, lymphedema rates were the following: external: 62.7%, internal: 41.7%, or combined: 29.2%, and/or fibrosis: 42.2%. Ranges of lymphedema late-effect rates were even higher: external: 81.9%-90.1%, internal: 80.4%-89.4%, combined: 70.6%-80.9%, and fibrosis: 66.7%-77.4%. Approximately 75% had a late-effect trajectory characterized by moderate to severe external or internal lymphedema; *47% had moderate to severe fibrosis. Conclusion: Lymphatic and soft tissue complications of HNC occur not only post-treatment but also before treatment. They are ubiquitous throughout the first 18 months post-treatment, with greater than 90% of patients in our study experiencing some form of internal, external, or combined lymphedema, and over half of those patients developing fibrosis. Further research regarding these conditions is indicated.

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confidence: 94%

A Prospective Study of the Lymphedema and Fibrosis Continuum in Patients with Head and Neck Cancer

Ridner

Dietrich

Niermann

et al. 2016

Lymphatic Research and Biology

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105

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“…Lymphedema is one of the under-reported but common side effects of head and neck cancer therapy. One recent study has shown that 75.3% of head and neck cancer patients were found to have lymphedema [7]. In the European literature, the prevalence of secondary lymphedema after head and neck cancer, whether with combined or single treatment, varies between 12% and 54% [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Severe lymphedema may be life-threatening also (as in our case). Recent study have shown that tumor location, months since the end of head & neck cancer treatment, total dosage of radiation therapy, days of radiation, radiation status of the surgical bed and number of treatment modalities were significantly associated with the presence of head and neck lymphedema [7]. Management of lymphedema is supportive.…”

Section: Discussionmentioning

confidence: 99%

Life Threatening Lymphoedema in Head and Neck Cancer

Singhal¹

2015

J Clin Case Rep

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Case summary61 year old male patient presented with the complaints of severe breathlessness, difficulty in swallowing and progressively increasing swelling all over face and neck to a local hospital where he underwent emergency tracheostomy and percutaneous endoscopic gastrostomy (PEG) for feeding. Eight years earlier, he was diagnosed to have carcinoma left tongue and underwent left hemiglossectomy with supraomohyoid dissection followed by radiotherapy (60 Gy in 30 fractions). Thereafter, he remained asymptomatic for six years. Two years earlier, he had non-healing ulcer on right side of tongue (Figure 1), biopsy of which revealed undifferentiated squamous cell carcinoma on histopathology and diagnosed to have recurrence of tongue cancer on right side for which he underwent right hemiglossectomy with supraomohyoid dissection followed by radiotherapy (45 Gy in 25 fractions) which he tolerated well with dry desquamation of skin and mucositis which was managed symptomatically.General examination on present admission revealed temperature: 98°F, pulse rate: 102/minute, blood pressure: 120/72 mm Hg, respiratory rate: 18/minute and swelling all over face and neck with skin dehiscence watery discharge. Respiratory system examination revealed crepitation in right basal region on auscultation. Other systemic evaluation was unremarkable. Laboratory investigation revealed hemoglobin: 12.5 gm/ dl, total leukocyte count of 21,400/cm 3 with neutrophil predominance (72%). Other biochemical and serological parameter were within normal limits. He was managed with broad spectrum antibiotics and other supportive care. Despite best supportive care, patient's condition continued to worsen and succumbed to his illness.

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“…По данным J. Deng и соавт., в 2012 г. в США более 500 тыс. пациентов с опухолями головы и шеи находятся в группе риска развития лим-федемы [5]. Авторы отмечают, что лимфедема данной локализации чаще встречается при опухолевом пораже-нии гортани [5].…”

Section: Introductionunclassified

“…пациентов с опухолями головы и шеи находятся в группе риска развития лим-федемы [5]. Авторы отмечают, что лимфедема данной локализации чаще встречается при опухолевом пораже-нии гортани [5]. По другим данным, вторичная лимфе-дема чаще развивается у пациентов с опухолями рото-глотки (p = 0,044) [6].…”

Section: Introductionunclassified

Lymphedema after combination treatment of head and neck tumors

et al. 2018

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ВведениеЛимфедема области головы и шеи, как и лимфедемы других локализаций, может быть первичной и вторич-ной. Первичная лимфедема развивается при врожден-ных аномалиях лимфатической системы и встречается достаточно редко. Вторичная лимфедема формируется при поражении лимфатической системы области голо-вы и шеи после лечения опухолей данной локализации и при метастатическом поражении [1].Распространенность вторичной лимфедемы области головы и шеи значительно ниже по сравнению с рас-пространенностью вторичной лимфедемы конечностей [2]. Частота развития той или иной степени отека варьи-рует от 12,1 [3] до 90 % [4]. По данным J. Deng и соавт., в 2012 г. в США более 500 тыс. пациентов с опухолями головы и шеи находятся в группе риска развития лим-федемы [5]. Авторы отмечают, что лимфедема данной локализации чаще встречается при опухолевом пораже-нии гортани [5]. По другим данным, вторичная лимфе-дема чаще развивается у пациентов с опухолями рото-глотки (p = 0,044) [6]. Основные методы лечения опухолей данной локализации -хирургическое вмеша-тельство и лучевая терапия, и использование каждого их них может привести к появлению отека.A. Sember и соавт. опубликовали результаты ис-следования, проведенного в 2008-2015 гг. в Roy and Patricia Disney Family Cancer Center (США, Калифорния) с участием 190 пациентов с опухолями головы и шеи.

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Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer

Cited by 68 publications

References 16 publications

A Prospective Study of the Lymphedema and Fibrosis Continuum in Patients with Head and Neck Cancer

A Prospective Study of the Lymphedema and Fibrosis Continuum in Patients with Head and Neck Cancer

Life Threatening Lymphoedema in Head and Neck Cancer

Lymphedema after combination treatment of head and neck tumors

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