Background: Globally , nearly three fourth of infants less than-six was not exclusively-brestfeed. While in Ethiopia, the proportion was only slightly above half. In refugee, setting life is not stable, due to lack of infrastructure and adequate health care service mother and infant face many health related problems, like interruption of exclusively breastfeed which intern lead them to malnutrition and impaired growth.Objectives: To assess the Determinants of Interruption of Exclusive Breastfeeding among mother who have infant less than six month at Dollo Ado Refugees camp, Ethiopia, 2017.Methods: A case -control study design was conduct at Dollo Ado refugee camp from April 05 to 25, 2017. Simple random sampling technique used to select 111 eligible case and 222 controls during the study period. A structured and pretested interviewer administered questionnaire used to collect the data. Logistic regression models fitted to assess significant factor, which determine interruption of Exclusive breast-feeding in the study area.Results: In this study not getting antenatal counseling about infant feeding (A-OR =5.87, 2.63-13.10), postnatal counseling about infant feeding (A-OR= 4.33, 2.7 - 10.78) and presence of problem of breastfeeding (AOR= 10.72, 4.55 - 25.23), late initiation of breastfeeding (AOR= 4.79, 2.28-10.0) were significant determinants of interruption of exclusive breastfeeding.Conclusions : In this study, not getting antenatal and postnatal counseling about infant and young child feeding, problem of breastfeeding, late initiation of Exclusive breastfeeding were significant determinants of interruption of EBF. Planer and manager should focus on provision of mother advice on Infant and Young Child Feeding during Antenatal and Postnatal Care. Health professional should be alert on treating problem of breastfeeding.