Factors associated with elevated serum chromogranin A levels  in patients with autoimmune gastritis

Kalkan, Çağdaş; Karakaya, Fatih; Soykan, İrfan

doi:10.5152/tjg.2016.16486

Cited by 4 publications

(8 citation statements)

References 21 publications

(28 reference statements)

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“…AIG was also more frequent in women ( P = 0.0023), as described before. Histologically‐confirmed AIG was significantly more frequent ( P = 0.0087) in the High CgA group (9 AIG cases vs 0 cases, odds ratio ∞ due to division by zero, CI 95% 2.23–∞).…”

Section: Resultssupporting

confidence: 69%

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Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis

Herold

Nagy

et al. 2020

J of Diabetes Invest

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Aims/Introduction: The relationship of chromogranin A (CgA) levels above the normal range with various outcomes, such as glycated hemoglobin levels, enterochromaffin-like cell hyperplasia and autoimmune gastritis, was investigated in type 1 diabetes patients with special regard to the progression of comorbidities. Materials and Methods: A cohort study on 153 type 1 diabetes patients was carried out with a prospective branch on clinical and laboratory data, and a retrospective branch on histological data obtained by gastroscopy. Results: Patients with CgA levels above the upper limit of the normal range (n = 28) had significantly higher glycated hemoglobin levels (P = 0.0160) than those with CgA in the normal range (n = 125). The correlation between CgA and glycated hemoglobin was significant (P < 0.0001), but weak (R = +0.32). A slight, but steady elevation (P = 0.0410) in CgA level was observed to co-vary with the duration of type 1 diabetes. Enterochromaffin-like cell hyperplasia and autoimmune gastritis was significantly more frequent (P = 0.0087 for both) in the high CgA group. Detailed analyses on gastric tissue samples confirmed a progression of enterochromaffin-like cell hyperplasia (P = 0.0192) accompanied by CgA elevation (P = 0.0316). Conclusions: The early detection and follow up of the later progression of enterochromaffin-like cell hyperplasia and autoimmune gastritis into gastric neuroendocrine tumors, which have~100-fold greater incidence in type 1 diabetes patients, can be achieved by assessment of CgA levels. Therefore, the use of CgA could be considered as a novel auxiliary biomarker in the care of these type 1 diabetes complications.

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Section: Resultssupporting

confidence: 69%

“…AIG is present in 5–10% of type 1 diabetes patients compared with approximately 2% of the non‐type 1 diabetes population, and gastric NETs develop in approximately 4–9% of type 1 diabetes patients with AIG. Furthermore, ECL hyperplasia, AIG and gastric NETs are observed more often in women compared with men.…”

Section: Introductionmentioning

confidence: 99%

Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis

Herold

Nagy

et al. 2020

J of Diabetes Invest

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“…Therefore, determinants of elevated serum chromogranin A level in autoimmune gastritis patients are considered to be the serum gastrin level and the presence of ECL cell hyperplasia. 28 In conclusion, this large series of studies on patients with AIG highlights differences among older and younger patients. Autoimmune gastritis is a heterogeneous disorder not only for its symptoms, but also for the changes in the laboratory parameters it causes.…”

Section: Discussionmentioning

confidence: 70%

“…In another study, serum gastrin level and the presence of ECL cell hyperplasia were found to be independent factors that might affect serum chromogranin A level. Therefore, determinants of elevated serum chromogranin A level in autoimmune gastritis patients are considered to be the serum gastrin level and the presence of ECL cell hyperplasia …”

Section: Discussionmentioning

confidence: 99%

Differences between older and young patients with autoimmune gastritis

Kalkan

Soykan

2016

Geriatrics Gerontology Int

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There are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65 years-of-age. Elderly patients with autoimmune gastritis were investigated more commonly for vitamin B and/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromogranin A levels were significantly higher in older patients. Geriatr Gerontol Int 2017; 17: 1090-1095.

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“…Тем не менее происхождение нейроэндокринных клеток, определяющих его продукцию в аденокарциноме, остается неизвестным [8,9]. Кроме того, содержание хромогранина коррелирует с уровнем стресса [10], наличием и выраженностью аутоиммунного хронического гастрита, сопровождающегося нарушением пролиферации [11].…”

Section: внутренние болезни Original Researchunclassified

Diverticular disease of the collon: clinic -instrumental and immunomorphological parallels

Svistunov¹,

Осадчук²,

Киреева³

et al. 2018

Medical news of the North Caucasus

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1 первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет), Россия 2 Городская поликлиника № 52, Москва, Россия diVerticular disease of the collon: clinic-instrumental and immunomorphological parallels svistunov a. a. 1 , osadchuk m. a. 1 , Kireeva n. V. 1 , Zolotovitskaya a. m. 1 , lasareva a. e. 1 , shorina d. a. 1 , antonenko n. i. 1 , osadchuk m. m. 2 1 i. m. sechenov first moscow state medical university (sechenovskiy university), russia 2 city polyclinic № 52, moscow, russia Дивертикулярная болезнь толстой кишки с учетом увеличения доли пожилых людей в общей численности населения планеты относится к наиболее важным проблемам современного здравоохранения в связи с необходимостью постоянного наблюдения за пациентами из-за возможного развития осложнений в виде дивертикулита, перфорации, кровотечения и малигнизации. С этих позиций становится актуальной выработка ранних прогностических критериев течения дивертикулярной болезни толстой кишки на основе изучения основных показателей пролиферации, таких как Kisspeptin (KiSS1), р53, хромогранин-А (CgA). Ключевые слова: дивертикулярная болезнь толстой кишки, кисспептин, р53, хромогранин-А Diverticular colon disease, taking into account the increase in the proportion of older people in the total population of the planet, is one of the most important problems of modern health care, due to the need for constant monitoring of patients due to the possible development of complications such as diverticulitis, perforation, bleeding and malignancy. From these positions, it becomes relevant to develop early prognostic criteria for the severity of the diverticular colon disease based on the study of the main indicators of proliferation, such as Kisspeptin (KiSS1), p53, chromogranin-A (CgA).

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Factors associated with elevated serum chromogranin A levels in patients with autoimmune gastritis

Cited by 4 publications

References 21 publications

Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis

Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis

Differences between older and young patients with autoimmune gastritis

Diverticular disease of the collon: clinic -instrumental and immunomorphological parallels

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