Factors associated with effectiveness of the first dose of hepatitis B vaccine in China: 1992–2005

Cui, Fuqiang; Li, Li; Hadler, Stephen C.; Wang, Fuzhen; Zheng, Hui; Chen, Yuansheng; Gong, Xun; Hutin, Yvan; Cairns, K. Lisa; Liang, Xiaofeng; Yang, Weizhong

doi:10.1016/j.vaccine.2010.06.111

Cited by 42 publications

(35 citation statements)

References 17 publications

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“…Hepatitis B vaccines and immunoglobulin (HBIG) are highly effective methods (89-98%) of preventing perinatal transmission if given within 12-24 hours after birth. [32][33][34][35] According to the national immunization policy in Indonesia, the birth dose of the hepatitis B vaccine should be given within 7 days after birth and should be followed by three doses of combination vaccines including diphtheria, pertussis, tetanus and hepatitis B within the 2nd, 3rd, and 4th months (DPT-HB3). 27,36 The parents should bring their baby to the primary health center to receive the vaccine; however, many people in remote areas in Indonesia have difficulty reaching these centers due to geographical isolation.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant

Purwono

Juniastuti

Amin

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)-positive individuals in the general population was approximately 5-10%. The study aimed to investigate the hepatitis B virus (HBV) serological status and molecular profile among children, 15 years after adoption of a universal infant vaccination program in Indonesia. According to the Local Health Office data in five areas, the percentages of children receiving three doses of hepatitis B vaccine are high (73.9-94.1%), whereas the birth dose coverage is less than 50%. Among 967 children in those areas, the seropositive rate of HBsAg in preschool-and school-aged children ranged from 2.1% to 4.2% and 0% to 5.9%, respectively. Of the 61 HBV DNA-positive samples, the predominant genotype/subtype was B/adw2. Subtype adw3 was identified in genotype C for the first time in this population. Six samples (11.5%) had an amino acid substitution within the a determinant of the S gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type. The low birth dose coverage and the presence of a vaccine-escape mutant might contribute to the endemicity of HBV infection among children in Indonesia.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant

Purwono

Juniastuti

Amin

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Cui et al (9) demonstrated that several factors, including vaccination at birth, being born after 1998, residence in an urban area, and delivery in a hospital setting, are associated with HBV infection status. Taylor et al (11) reported that better education was positively associated with HBV vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…Routine surveillance of high-risk individuals and vaccination of the general public may decrease the spread of infection by increasing herd immunity. Vertical transmission may be controlled by ensuring hospital delivery, rigorous prenatal counseling of pregnant mothers, and utilization of standard management protocols, including administration of HBV vaccine and immunoglobulin (HBIG) to high-risk babies at the time of birth (9).…”

Section: Introductionmentioning

confidence: 99%

Public awareness of hepatitis B infection in Turkey as a model of universal effectiveness in health care policy

Gürakar¹,

Malik²,

Keskin³

et al. 2014

Turk J Gastroenterol

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Background/Aims:This study aimed to analyze the knowledge and awareness of hepatitis B virus (HBV) infection in an HBV-infected Turkish population as a model for global health care practice and to evaluate potential factors associated with the disease spread and its prevention. Materials and Methods: A cross-sectional survey was conducted in Ankara University School of Medicine, Liver Disease Outpatient Clinic between August 2012 and March 2013. The survey queried sociodemographics, knowledge, and awareness of HBV infection, transmission, and consequences and common practices and behaviors. Results: A total of 181 patients were surveyed (median age=49 years); 91 (51%) had "advanced" education levels (high school, bachelor's, graduate degree), 108 (60%) had knowledge about HBV infection and transmittance, and 130 (72%) were aware of the ill consequences of HBV infection. Also, 120 (66%) had vaccinated their family members against HBV infection. Participants with knowledge of HBV infection transmittance were more likely to vaccinate their family members compared to unknowledgeable participants (p=0.015). Participants with "advanced" education levels were also more likely to vaccinate family members (p=0.047). Conclusion: Promoting better awareness of HBV and endorsing mass educational interventions may be useful strategies to prevent the spread of HBV infection. Such strategies may be recommended as cost-effective global health care practices in HBV endemic areas.

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“…However, we were unable to differentiate the impact of receiving a hepatitis B vaccine dose ≤24 hours compared to 2-7 days after birth though the study was not powered for this analysis. In China, one study found no difference in seroprevalence between children who received a dose within ≤24 hours compared to 2-7 days, while a second study found that those who received a BD within 2-7 days were three times more likely to be HBsAg positive compared to children who received a BD within ≤24 hours [19,20]. Further research is needed to guide future policy recommendations on timing of the birth dose.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Mao

Patel

Hennessey

et al. 2013

Vaccine

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Factors associated with effectiveness of the first dose of hepatitis B vaccine in China: 1992–2005

Cited by 42 publications

References 17 publications

Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant

Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant

Public awareness of hepatitis B infection in Turkey as a model of universal effectiveness in health care policy

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

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