Factors Associated with Early Platelet Activation in Obese Children

García, Anel Gómez; Nunez, G; Sandoval, Martha Eva Viveros; Castellanos, Sergio Gutiérrez; Aguilar, Cleto Alvarez

doi:10.3121/cmr.2013.1166

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…Obesity is associated with glucose intolerance, type 2 diabetes, hypertension and other cardiovascular diseases (108,109). In a study by Garcia et al (110) investigating factors associated with platelet activation in obese children, vWF plasma levels were found to be elevated in obese children compared to non-obese children. Plasma levels of ADAMTS13 have been suggested to be low in obese individuals, and obesity independent of race and sex, was found to be a risk factor for the development of TTP (111).…”

Section: Obesitymentioning

confidence: 99%

The association of von willebrand factor and its cleaving protease (ADAMTS13) with health behaviours in young black and white adults: the African-PREDICT study

et al. 2021

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for their supervision, time, support, guidance, valuable intellectual input, helpful feedback and constructive criticism. Lastly, as a new student I am grateful to them for welcoming me with open arms and for being such great inspiration.  All the participants who participated in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension (African-PREDICT) for their voluntary participation. Without them the study would not be possible.  The Hypertension in Africa Research Team (HART) staff and students for their hard work and dedication. The National Research Foundation (NRF) for the financial assistance. Without their scholarship enrolling for this degree would not have been possible. My mother and sister for all their sacrifices, support and unconditional love. My grandparents for their support and never ending prayers. My friends for their support and encouragement. vi PREFACEThis dissertation (The association of von Willebrand factor and its cleaving protease

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Section: Obesitymentioning

confidence: 99%

The association of von willebrand factor and its cleaving protease (ADAMTS13) with health behaviours in young black and white adults: the African-PREDICT study

et al. 2021

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“…Although it is not known whether VWF plays a role in obesity and obesity-related metabolic disorders, raised plasma levels of VWF have been observed in patients with obesity (30,31), nonalcoholic fatty liver disease (32), and diabetes (33). Here, we found that plasma VWF levels were significantly elevated in obese mice compared with controls.…”

Section: Discussionmentioning

confidence: 49%

Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet

Yang

Lou

et al. 2020

Obesity

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Objective The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high‐fat diet (HFD)‐induced hepatic steatosis, insulin resistance, and inflammation in mice. Methods The expression of VWF was detected in obese mice. Wild‐type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD. Results VWF expression was significantly increased in obese mice. VWF−/− mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD‐induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages. Conclusions These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages.

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“…This finding stresses the concept of concomitant growth of adipose tissue and its vasculature. In line with this, VWF is elevated in the plasma of obese children, and there is evidence for a differential expression in microarray studies [32,33,34,35].…”

Section: Discussionmentioning

confidence: 79%

Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children

Gaebler¹,

Haggenmüller²,

Kapapa³

et al. 2019

IJMS

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The growth of adipose tissue and its vasculature are tightly associated. Angiogenic factors have been linked to obesity, yet little is known about their expression during early childhood. To identify associations of angiogenic factors with characteristics on individual and tissue level, subcutaneous white adipose tissue samples were taken from 45 children aged 0–9 years undergoing elective surgery. We measured the expression of vascular endothelial growth factor A (VEFGA), fibroblast growth factor 1 and 2 (FGF1, FGF2), angiopoietin 1 and 2 (ANGPT1, ANGPT2), TEK receptor tyrosine kinase (TEK), and von Willebrand factor (VWF). In addition, we determined the mean adipocyte size in histologic tissue sections. We found positive correlations of age with FGF1 and FGF2 and a negative correlation with ANGPT2, with pronounced differences in the first two years of life. FGF1, FGF2, and ANGPT1 correlated positively with adipocyte size. Furthermore, we identified a correlation of ANGPT1 and TEK with body mass index-standard deviation score (BMI-SDS), a measure to define childhood obesity. Except for ANGPT2, all angiogenic factors correlated positively with the endothelial marker VWF. In sum, our findings suggest that differences related to BMI-SDS begin early in childhood, and the analyzed angiogenic factors possess distinct roles in adipose tissue biology.

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Factors Associated with Early Platelet Activation in Obese Children

Cited by 10 publications

References 37 publications

The association of von willebrand factor and its cleaving protease (ADAMTS13) with health behaviours in young black and white adults: the African-PREDICT study

The association of von willebrand factor and its cleaving protease (ADAMTS13) with health behaviours in young black and white adults: the African-PREDICT study

Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High‐Fat Diet

Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children

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